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| 1 | 阿米福汀对放射性肺损伤保护作用的实验研究显示文摘目的 用荷瘤和无瘤大鼠的放射性肺损伤模式评价阿米福汀 (Amifostine,WR 2 72 1)的放射性肺损伤保护作用。方法 选 15 0~ 16 0g的Fisher 34 4雌性大鼠 ,在右后胸壁种植R32 30AC人乳腺癌细胞株 ,肿瘤长至直径为 1.0~ 1.5cm时和无肿瘤大鼠随机进入实验组。用 4MVX射线、剂量DT35Gy5分次 5d照射右全肺 ,每次照射前 30min腹腔内注射Amifostine(15 0mg kg)。照射后观测呼吸频率、肿瘤大小和转化生长因子 (TGF β1 )水平。当出现呼吸困难伴体重下降时 ,终止观察 ,否则在 6个月后终止观察。肺组织进行羟脯胺酸和TGF β1 表达等生物学检测。结果 治疗后第 3d体重下降明显 ,照射加Amifostine(15 % )和单用Amifostine(11% )与单纯放射 (7% )间有明显的差别。肿瘤生长延迟和肿瘤生长情况及因肿瘤肺转移死亡贡献生存率 ,用药与未用药者相似。无瘤大鼠单纯照射组的平均呼吸频率增加早 (第 9周开始 )、幅度高 (12 5~ 12 7次 min) ,照射加药组在第 12周开始 ,115~ 118次 min(P <0 .0 0 1)。单纯照射组羟脯胺酸含量明显高于照射加amifostine组 (P =0 .0 42 )、单用药组和对照组 (P <0 .0 1)。血浆TGF β1 含量在照射后 1~ 3个月增加、2个月达高峰 ,单放组的TGF β1 含量[(5 .32± 1.2 1)ng | 冯勤付 Vujaskovic Z Brizel DM Anscher MS | 2001 | 中华放射肿瘤学杂志2001，10，4： | 47 |
| 2 | 阿米福汀对单次肺照射的保护作用及TGF-β1活性的影响显示文摘目的用大鼠放射性肺损伤模式评价阿米福汀对单次肺照射的放射性肺损伤保护作用和对TGFβ1活性变化的影响。方法34只150~160g的Fish344雌性大鼠随机进入照射加药(11只)、单纯照射(11只)、单用药(6只)和正常对照(6只)实验组。用4MVX射线单次28Gy照射右全肺,照射前30min腹腔内注射阿米福汀150mg/kg。每2周观测呼吸频率和血浆转化生长因子(TGFβ1)水平,在6个月后终止观察。肺组织进行羟脯胺酸、胶原蛋白含量、总TGFβ1与活性TGFβ1水平、TGFβ1蛋白表达和巨噬细胞量等检测。结果单纯照射组呼吸频率于第8周发生改变、达(185±13)次/min,3只因呼吸困难终止观察,7只有胸腔积液;照射加药组于第14周开始增加,仅为(125±5)次/min,无呼吸困难和胸腔积液发生。单纯照射组的肺组织结构消失纤维化,照射加药组也有纤维化,但保持大部分肺泡结构。血浆TGFβ1水平呈双峰改变,单纯照射组12周时为(3.2±0.5)ng/ml,较照射加药组(1.3±0.3)ng/ml明显增高(P=0.004);肺组织活性TGFβ1与总TGFβ1含量之比分别为3.9%±0.2%与3.1%±0.2%,单纯照射明显高于照射加药组(P<0.05)。结论阿米福汀不仅能增加肺组织对放射性损伤的耐受,同时也能减少TGFβ1的含量与表达,也许同时能减少TGFβ1的活性表达。 | 冯勤付 Vujaskovic Z Brizel DM Anscher MS | 2004 | 中华放射肿瘤学杂志2004，13，3： | 12 |
| 3 | Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck显示文摘 | Brizel DM Sibley GS Prosnitz LR | 1997 | Int J Radiat Oncol Biol Phys1997，38，2： | 2 |
| 4 | Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma 显示文摘 | Brizel DM ScuIly SP Harrelson JM | 1996 | Cancer Res1996，56，2： | 1 |
| 5 | Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck显示文摘 | Brizel DM Sibley GS Prosnitz LR | 1997 | Int J Radiat Oncol Biol Phys1997，38，2： | 1 |
| 6 | The radiation dose response relationship in a human glioma xenograft and an evaluation of the influ- ence of glutat hione depletion by but hionine sulfoximine显示文摘 | Halperin EC Brizel DM Honore G | 1992 | IntJ Radiat Oncol Biol Phys1992，24，： | 1 |
| 7 | Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer显示文摘 | Brizel DM Albers ME Fisher SR | 2013 | New England Journal of Medicine2013，01，25： | 1 |
| 8 | How much radiation is the chemotherapy worth in advanced head and neck cancer 显示文摘 | Kasibhatla M Kirkpatrick JP Brizel DM | 2007 | Int J Radiat Oncol2007，68，5： | 1 |
| 9 | Pharmcologic Approaches to radiation protection 显示文摘 | Brizel DM | 2007 | J Clin Ontol2007，25，26： | 1 |
| 10 | Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma显示文摘 | Brizel DM Scully SP Harrelson JM | 1996 | Cancer Res1996，56，5： | 1 |
| 11 | Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head and - neck cancer: 2 - year follow- up of a prospective, randomized, phase Ⅲ trial 显示文摘 | Wasserman TH Brizel DM Henke M | 2005 | Int J Radiat Oncol Biol Phys2005，63，4： | 1 |
| 12 | Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer显示文摘 | Brizel DM Albers ME Fisher SR | 1998 | N Engl J Med1998，338，： | 1 |
| 13 | Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma显示文摘 | Scully SP Harrelson JM | 1996 | Cancer Res1996，56，5： | 1 |
| 14 | Phase Ill randomized trial of amifostine as a radiop mtector in head and neck cancer显示文摘 | Brizel DM Wasserman TH Henke M | 2000 | J Clin Oncol2000，18，： | 1 |
| 15 | Phase-Ⅲ randomized trial of amifostine as a radioprotector in head and neck cancer显示文摘 | Wasserman TH Henke M | 2000 | J Clin Oncol2000，18，19： | 1 |
| 16 | The potential role of intrinsic hy- poxia markers as prognostic variables in cancer 显示文摘 | Moon EJ Brizel DM Chi JT | 2007 | Antioxid Redox Signal2007，9，8： | 1 |
| 17 | Phase Ⅲ randomized trial of amifostine as a radioprotector in head and neck cancer显示文摘 | Brizel DM Wasserman TH Henke M | 2000 | J Clin Oncol2000，18，： | 1 |
| 18 | Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer显示文摘 | Brizel DM Schroeder T Scher RL | | 0，，02： | 1 |
| 19 | Effect of amifostine on patient assessed clinical benefit in irradiated head-and-neck cancer显示文摘 | Wasserman T Mackowiak JI Brizel DM | 2000 | Int J Radiat Oncol Biol Phys2000，48，： | 1 |
| 20 | Phase III random- ized trial of amifostine as a radioprotectorin head and neck canc- er显示文摘 | Brizel DM Wasserman TH Henke M et a! | 2000 | J Clin Oncol2000，18，： | 1 |
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