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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Molecular characterization of FOX- 4, a new AmpC-type plasmid-mediated beta-lactamase from an Escherichia coli strain isolated in Spain 显示文摘 | Bou G Oliver A Ojeda M | 2000 | Antimicrob Agents Chemother2000，44，9： | 1 |
| 3 | OXA-24,a novel class D betalactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain显示文摘 | Oliver A Martinez-Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 4 | l Comparison of nebu lized budeson ide and oral predn iso lone with p lacebo in th e treatment of acu te exacerbations of chron ic obstructive pulmon ary disease:a randomized controlled tria显示文摘 | Maltais F Os tinelli J Bou rbeau J et a | 2002 | l Am J Resp ir Crit CareM ed2002，165，： | 1 |
| 5 | Conformation of tri-and tetra-substituted 2-fluorocyclohexanones:proton non-equivalence F-H and F-C coupling constants,conformational dependence of ^3JFH and ^4JFH显示文摘 | Solladié-Cavallo A Jierry L Bouérat L | 2002 | Tetrahedron2002，58，： | 1 |
| 6 | miR-449 inhibits cell proliferation and is down-regu- lated in gastric cancer显示文摘 | BOU KHEIR T FUTOMA-KAZMIERCZAK E JACOBSEN A | 2011 | Mol Cancer2011，18，10： | 1 |
| 7 | OXA-24,a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain显示文摘 | Bou G Oliver A Martinez-Beltran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 8 | Delta opioid receptors mediatechemotaxis in bone marrow-derived dendritic cells显示文摘 | Bénard A BouéJ Chapey E | 2008 | J Neuroim-munol2008，197，1： | 1 |
| 9 | OXA-24,a novel class Acineto-bacter baumannii clinical strain显示文摘 | Bou G Oliver A Martrinez J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 10 | Oxa 24,a novel class D beta lactamase with carbapenemase activity in an Axinetobacter baumannii clinical strain显示文摘 | OLIBER A MARTINEZ BELTRAN J | 2006 | Antimicrob Agents Chenother2006，44，6： | 1 |
| 11 | Effect of tocopherol ex- tract,Staphylococcus carnosus culture, and celery concen- trate addition on quality parameters of organic and conven- tional dry- cured sausages显示文摘 | Magrinya N Bou R Tres A | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
| 12 | OXA- 24, a novel class D beta- lac-tamase with carbapenemase activity in an Acinetobacter baumannil clinical strain 显示文摘 | Bou G Oliber A Martinez- Behran J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 13 | Microstructural Study of Opaque Glazes Obtained from Frits of the System:SiO2-Al2O3-B2O3-(P2O5)-CaO-K2O-TiO2显示文摘 | Bou E Moreno A Escardino A | 2007 | Journal of the European Ceramic Society2007，27，23： | 1 |
| 14 | Sleeve gastrectomy in a 10-year-old child显示文摘 | Baltasar A Serra C Bou R | 2008 | Obes Surg2008，18，6： | 1 |
| 15 | Molecular characterization of FOX-4, a new AmpC-type plasmid-mediated beta-lactamase from art Escherichia coli strain isolated in Spain 显示文摘 | Bou G Oliver A Ojeda M | 2000 | Anti- microb Agents Chemother2000，44，9： | 1 |
| 16 | Rate, predictors, and consequences of hemodynamic depression after carotid artery stenting显示文摘 | Gupta RA bou Chebl A Bajzer CT | 2006 | J Am Coil Cardiaol2006，47，： | 1 |
| 17 | Acomparative study between catalase gene therapy and the cardio protector monohydroxyethylru to side (MonoHER) in protecting against doxorubicin-induced cardio toxicity in vitro 显示文摘 | A bou El-Hassan MA Rabelink MJ vander V ijgh WJ etal | 2003 | Br J Cancer2003，89，11： | 1 |
| 18 | Age-related equations for above-and below-ground biomass of a Eucalyptus hybrid in Congo显示文摘 | Saint-Andre L M' Bou A T Mabiala A | 2005 | Forest Ecology and Management2005，205，： | 1 |
| 19 | OXA-24,a novel class D beta-lactamase with carbapenemase activity in an acinetobacter baumannii clinical strain显示文摘 | Bou G Olive A Martinez-Beltr J | 2000 | Antimicrob Agents Chemother2000，44，6： | 1 |
| 20 | Class C beta- Lactamases: an increasing problem worldwide显示文摘 | BECEIRO A BOU G | 2004 | Reviews in Medical Microbiology2004，15，4： | 1 |
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