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| 1 | Laparoscopic resection vs laparoscopic radiofrequency ablation for the treatment of small hepatocellular carcinomas: A single-center analysis显示文摘AIM To compare survival and recurrence after laparoscopic liver resection(LLR) and laparoscopic radiofrequency ablation(LRFA) for the treatment of small hepatocellular carcinoma(HCC).METHODS Between June 1, 2005 and November 30, 2010, 46 patients(62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR(n = 24), while those with poorer liver function and multiple tumors were referred for LRFA(n = 22), and they were then followed for similar durations(44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA). RESULTS The LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival(OS) and disease-free survival(DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group(LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS(LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules(LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P < 0.001). Cox regression analysis found the number of intraoperative HCC nodules as the unique variable statistically significant for OS(hazard ratio: 2.225; P < 0.001). The rank-hazard plot showed a steeper increase of relative hazard for intraoperative nodules > 2.CONCLUSION Our preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients. | Marco Casaccia Gregorio Santori Giuliano Bottino Pietro Diviacco Enzo Andorno | 2017 | World Journal of Gastroenterology2017，23，4： | 20 |
| 2 | Gastrointestinal stromal tumour of the rectum: Report of a case and review of literature显示文摘Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CD117 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and non-metastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST. | Nello Grassi Calogero Cipolla Adriana Torcivia Stefano Mandalà Giuseppa Graceffa Alessandro Bottino Federica Latteri | 2008 | World Journal of Gastroenterology2008，14，8： | 6 |
| 3 | The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation显示文摘There is a critical shortage of organs, cells, and corneas from deceased human donors worldwide. There are also shortages of human blood for transfusion. A potential solution to all of these problems is the transplantation of organs, cells, and corneas from a readily available animal species, such as the pig, and the transfusion of red blood cells from pigs into humans. However, to achieve these ends, major immunologic and other barriers have to be overcome. Considerable progress has been made in this respect by the genetic modification of pigs to protect their tissues from the primate immune response and to correct several molecular incompatibilities that exist between pig and primate. These have included knockout of genes responsible for the expression of major antigenic targets for primate natural anti-pig antibodies, insertion of human complementand coagulation-regulatory transgenes, and knockdown of swine leukocyte antigens that stimulate the primate's adaptive immune response. As a result of these manipulations, the administration of novel immunosuppressive agents, and other innovations, pig hearts have now functioned in baboons for 6-8 months, pig islets have maintained normoglycemia in diabetic monkeys for > 1 year, and pig corneas have maintained transparency for several months. Clinical trials of pig islet transplantation are already in progress. Future developments will involve further genetic manipulations of the organsource pig, with most of the genes that are likely to be beneficial already identified. | David K.C.Cooper Hidetaka Hara Mohamed Ezzelarab Rita Bottino Massimo Trucco Carol Phelps David Ayares Yifan Dai | 2013 | The Journal of Biomedical Research2013，27，4： | 6 |
| 4 | Micromorphological investigation on the leaves of the rock samphire (Crithmum maritimum L.): Occurrence of hesperidin and diosmin crystals显示文摘 | L. Cornara C. D'Arrigo F. Pioli B. Borghesi C. Bottino E. Patrone M. G. Mariotti | 2009 | Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology2009，，2： | 2 |
| 5 | Use of genetically-engineered pig donors in islet transplantation显示文摘Type 1 diabetes(T1D) is an autoimmune disease wherein the pancreas does not produce enough insulin due to islet beta cell destruction. Despite improvements in delivering exogenous insulin to T1 D patients, pancreas or islet transplantation remains the best way to regulate their glycaemia. Results from experimental islet transplantation have improved dramatically in the last 15 years, to the point where it can be comparable to pancreas transplantation, but without the accompanying morbidity associated with this procedure. As with other transplants, the limiting factor in islet allotransplantation is the relatively small number of organs made available by deceased human donors throughout the world. A strong case can be made for islet xenotransplantation to fill the gap between supply and demand; however, transplantation across species presents challenges that are unique to that setting. In the search for the most suitable animal for human xenotransplantation, the pig has many advantages that make it the likely animal of choice. Potentially one of the most beneficial advantages is the ability to genetically engineer porcine donors to be more compatible with human recipients. Several genetic manipulations have already proven useful in relation to hyperacute rejection and inflammation(instant blood mediated inflammatory reaction), with the potential of even further advancement in the near future. | Rita Bottino Massimo Trucco | 2015 | World Journal of Transplantation2015，5，4： | 2 |
| 6 | Surface NK receptors and their ligands on tumor cells显示文摘 | Moretta L Bottino C Pende D | 2006 | J Semin Immunol2006，18，3： | 1 |
| 7 | Preparation of ultrafiltration membranes: State of the art显示文摘 | Munari S Bottino A Camera R G | 1990 | Desalination1990，77，： | 1 |
| 8 | Microtensile bond strength of a resin cement to glass infiltrated zirconiareinforced ceramic:The effect of surface conditioning显示文摘 | Amaral R Ozcan M Bottino MA | 2006 | Dent Mater2006，22，3： | 1 |
| 9 | Effects of sulfonylureas on KATI, channel-dependent vasodilation 显示文摘 | Cyrino FZG Bottino DA Coelho FC | 2003 | Diabetes and Its Complications2003，17，： | 1 |
| 10 | Y-TZP ceramic processing from coprecipitated powders: a comparative study with three commercial dental ceramics显示文摘 | LAZAR D R R BOTTINO M C ZCAN M | 2008 | Dental Materials2008，24，12： | 1 |
| 11 | High performance ultrafiltration membranes cast from LiCI doped solutions显示文摘 | Bottino A Capannelli G Munari S | 1988 | Desalination1988，68，： | 1 |
| 12 | Preservation of human islet cell functional mass by anti-oxidativeaction of a novel SOD mimic compound显示文摘 | BOTTINO R BALAMURUGAN A N BERTERA S | 2002 | Journal of Diabetes2002，51，8： | 1 |
| 13 | Bond strength of a resin cement to high-alumina and zirconia-reinforced ceramics:the effect of surface conditioning显示文摘 | Valandro LF Ozcan M Bottino MC | | 0，，03： | 1 |
| 14 | Influence of thermal and mechanical cycling on the flexural strength of ceramics with titanium or gold alloy frameworks显示文摘 | Oyafuso DK Ozcan M Bottino MA | 2008 | Dent Mater2008，24，3： | 1 |
| 15 | What is a natural killer cell显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，： | 1 |
| 16 | Hnman natural killer cells:their origin,receptors and function显示文摘 | Moretta L Bottino C Pende D | 2002 | Eur J Immunol2002，32，5： | 1 |
| 17 | How nematode sperm crawl显示文摘 | Bottino D Mogilner A Roberts T | 2002 | Journal of Cell Science2002，115，： | 1 |
| 18 | The formation of microporous polyvinylidene difluoride membranes by phase separation显示文摘 | Camera-Roda G Capannelli G | 1991 | J Membr Sci1991，57，： | 1 |
| 19 | Effector and regulatory events during natural killer-dendritic cell interactions显示文摘 | Moretta L Ferlazzo G Bottino C | 2006 | Immunol Rev2006，214，： | 1 |
| 20 | Synthesis of Glycidyl Calixarenes显示文摘 | Neri P Bottino A Geraci C | 1996 | Tetrahedron Asym1996，7，： | 1 |
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