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| 1 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 2 | 4-aryl-dihydropyridine, a new class of highly active calcium antagonists 显示文摘 | Bossert Friedrich Meyers H Wehinger E | 1981 | Angew Chem Int Ed Engl1981，20，9： | 1 |
| 3 | Selfreportedfearsofhospitalizedschoolagechildren显示文摘 | HartD BossertE | 1994 | JournalofPediatRicNursing1994，，2： | 1 |
| 4 | A characterization of consistent collective choice rules 显示文摘 | Bossert W Suzumura K | 2008 | Journal of Economic Theory2008，138，： | 1 |
| 5 | Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon induced antiviral response 显示文摘 | Schlender J Bossert B Buchholz U | 2000 | J Virol2000，74，18： | 1 |
| 6 | 1,4-Dihydropyridines-a basis for developing new drugs显示文摘 | Bossert F Vater W | 1989 | Med Res Rev1989，9，3： | 1 |
| 7 | Cancer pain in children: The selection of a model to guide research 显示文摘 | Van Cleve L Bossert EA Savedra MC | 2002 | Journal for special- ists in pediatric nursing : JSPN2002，7，4： | 1 |
| 8 | P-cresol methylhydroxylase from a denitrifying bacterium involved in anaerobic degradation of P-Cresol显示文摘 | Hopper D J Bossert I D Rhodes-Roberts M E | 1991 | Journal of Bacteriology1991，173，3： | 1 |
| 9 | Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3 显示文摘 | Bossert B Marozin S Conzelmann K K | 2003 | J Virol2003，77，： | 1 |
| 10 | Allotransplantod neurons used to repair peripheral nerve injury do not elicit overt immunogenicity显示文摘 | ADAM BOSSERT | 2012 | PLoS One2012，7，31： | 1 |
| 11 | 显示文摘 | MANUKYAN K DAVTYAN D BOSSERT J | 2011 | Chem Eng J2011，168，： | 1 |
| 12 | Array codes correcting two-dimensional cluster of errors显示文摘 | Markus Breitbach Martin Bossert | 1998 | IEEE Transaction on Information Theory1998，44，5： | 1 |
| 13 | Self - reported fears of hospitalized school - agechildren显示文摘 | Hart D Bossert E | 1995 | Journal of Pediatric Nursing1995，35，2： | 1 |
| 14 | 4 - Aryldihydropyridine, a new class of highly active calcium antagonists 显示文摘 | Bossert F Meyer H Wehinger E | 1981 | Angew Chem Int Ed Engl1981，20，： | 1 |
| 15 | Chemical communication among animals显示文摘 | Wilson E O W H Bossert | 1963 | Rec Progr Hormone Res1963，19，： | 1 |
| 16 | Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA显示文摘 | Mulheron GW Bossert NL Lapp JA | 1992 | J Clin Endocrinol Metab1992，74，2： | 1 |
| 17 | Fate of hydrocarbons during oily sludge disposal in soil显示文摘 | Bossert I Bartha R | 1984 | Appl Environ Microbiol1984，47，： | 1 |
| 18 | Adaptive coding and modulation in MIMO-OFDMA systems显示文摘 | STIGLMAYR S KLOTZ J BOSSERT M | 2008 | IEEE 19th International Symposium on PIMRC2008，，7： | 1 |
| 19 | The potential and promise of physics - based wildfire simulation 显示文摘 | Hanson H P Bradley M M Bossert J E | 2000 | Environmental Science &Policy2000，，3： | 1 |
| 20 | Cardiac malformations associated with the Holt-Oram syndrome -report on a family and review of the literature显示文摘 | BOSSERT T WALTHER T GUMMER T J | 2002 | Thorac Cardiovasc Surg2002，50，： | 1 |
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