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| 1 | Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential显示文摘学习的主要目标是多识别人的新奇来源有势力房间,克服涉及胚胎的干细胞研究和很成年的干细胞的有限可获得性的道德的问题。羊膜的液体房间(声频抗流圈) 习惯性地为出生前的诊断被获得并且能在 vitro 被扩展;他们的起源和性质的不过当前的知识是有限的。声频抗流圈的二十件样品在文化暴露于 adipogenic, osteogenic,神经原并且 myogenic 媒介。区别用免疫细胞化学, RT-PCR 并且西方的弄污被评估。在处理前,声频抗流圈显示出异构的形态学。他们为 MyoD, Myf-5, MRF4, Myogenin 和 Desmin 是否定的但是为由 RT-PCR 的 osteocalcin, PPARgamma2, GAP43, NSE, Nestin, MAP2, GFAP 和贝它导管素 III 积极。房间表示了 Oct-4, Rex-1 和 Runx-1,它描绘无差别的干细胞状态。由免疫细胞化学,他们表示了 neural-glial 蛋白质,间充质、上皮的标记。在文化以后,当占优势的细胞的部件是 fibroblastic 时,声频抗流圈区分了进 adipocytes 和造骨细胞。就算没有 neuronal 形态学是可检测的,早、迟了的 neuronal 抗原仍然是在在神经特定的媒介的 2 星期文化以后的现在。我们的结果提供人的羊膜的液体与为几个系显示出茎和织物特定的基因 / 蛋白质存在的多系潜力包含祖先房间的证据。 | Patrizia Bossolasco Tiziana Montemurro Lidia Cova Stefano Zangrossi Cinzia Calzarossa Simona Buiatiotis Davide Soligo Silvano Bosari Vincenzo Silani Giorgio Lambertenghi Deliliers PaoloRebulla LorenzaLazzari | 2006 | Cell Research2006，16，4： | 20 |
| 2 | HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists显示文摘Management of cancers of the digestive system has progressed rapidly into the molecular era. Despite the significant recent achievements in the diagnosis and treatment of these patients, the number of deaths for these tumors has currently plateaued. Many investigations have assessed the role of HER2 in tumors of the digestive system in both prognostic and therapeutic settings, with heterogeneous results. Novel testing and treatment guidelines are emerging, in particular in gastric and colorectal cancers. However, further advances are needed. In this review we provide a comprehensive overview of the current state-ofknowledge of HER2 alterations in the most common tumors of the digestive system and discuss the operational implications of HER2 testing. | Nicola Fusco Silvano Bosari | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 3 | Helicobacter pylori-negative Russell body gastritis:Case report显示文摘Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions.Very few cases have been reported in the literature;the majority of which have shown Helicobacter Pylori(H.pylori)infection,thus suggesting a correlation between plasma cell presence and antigenic stimulation by H.pylori.We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric pain.Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies.Giemsa staining for H.pylori infection was nega-tive,as well as immunohistochemical detection.The cells with eosinophilic inclusions stained positive for CD138,CD79a,andκand lambda light chains,which confirmed plasma cell origin.In particular,κand lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia.The histological observations were confirmed by ultrastructural examination.The cases reported in the literature associated with H.pylori infection have shown regression of plasma cells after eradication of H.pylori.Nothing is known about the progression of H.pylori-negative cases.The unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination,and it should be distinguished from other common forms of chronic gastritis.It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy,which can help with differential diagnosis.The long-term effects of plasma cells hyperactivation are still unknown,because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the literature.We are of the opinion that these patients should be scheduled for endoscopic surveillance. | Alessandro Del Gobbo Luca Elli Paola Braidotti Franca Di Nuovo Silvano Bosari Solange Romagnoli | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 4 | P53 immunoreactivity in inflammatory and neoplastic disease of the uterine cervix显示文摘 | Bosari S Roncalli M Roncall M | 1993 | J Pathol1993，169，4： | 1 |
| 5 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosaris S Lee AKC Delellis RA | 1992 | Human Pathology1992，23，： | 1 |
| 6 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosari S Lee AK Delellis RA | 1992 | Hum Pathol1992，23，7： | 1 |
| 7 | Analysis of monoamine oxi- dase A (MAO-A) promoter polymorphism in male heroin-depen- dent subject: behavioural and personality correlates显示文摘 | Gerra G Garofano L Bosari S | 2004 | Neural Transm2004，111，5： | 1 |
| 8 | Microvessel quantitation and prognosis in invasive breast carcinoma显示文摘 | Bosari S Lee AK DeLellis RA | 1992 | Hum Pathol1992，23，7： | 1 |
| 9 | Cytolasmic accumulation of p53 protein: an independent prognostic indicator of colorectal adenocarcinimas显示文摘 | Bosari S Viale G Bossi P | 1994 | Cancer Inst1994，84，： | 1 |
| 10 | Intraoperative examination of axillary sentinel node in breast carcinoma patients 显示文摘 | Viale G Bosari S Mazzarol G | 1999 | Cancer1999，85，1： | 1 |
| 11 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosari S Lee AKC Delellis RA | 1992 | Human Pathol1992，23，4： | 1 |
| 12 | Microvessel quantitation and prognosis in invasive breast carcinoma显示文摘 | Bosari S Lee AKC Delellis RA | 1992 | Hum Pathol1992，23，： | 1 |
| 13 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosari S Lee AK Delellis RA | 1992 | Hum Pathol1992，23，7： | 1 |
| 14 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosari S Lee AK Delellis RA | 1992 | Hum Pathol1992，23，7： | 1 |
| 15 | Intraoperative examination of axillary sentinel nodes in breast carcinoma patients显示文摘 | Viale G Bosari S Mazzarol G | 1999 | Cancer1999，85，1： | 1 |
| 16 | p53 accumulationin ovarian carcinomas and its prognostic placations显示文摘 | Bosari S | 1993 | Hum Pathol1993，24，： | 1 |
| 17 | Microvessel quantitation and prognosis in invasive breast carcinoma 显示文摘 | Bosari S Lee AK Delellis RA | 1992 | Hum Pathol1992，23，： | 1 |
| 18 | Microvessel quantitation and prognosis in invasive breast carcinoma显示文摘 | Bosari S Lee A K Delellis R A | | 0，，7： | 1 |
| 19 | Microvessel quantitation and prognosis in invasive breast carcinoma显示文摘 | BOSARI S LEE A K DELELLIS R A | 1992 | Hum Pathol1992，23，： | 1 |
| 20 | p53 accumulation in ovarian carcinomas and prognostic implications 显示文摘 | Bosari S Viale G Radaelli U | 1993 | Hum Pathol1993，24，： | 1 |
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