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| 1 | Impact of primary tumour location on colorectal liver metastases: A systematic review显示文摘BACKGROUND Colorectal cancer(CRC)is the third most common cause of cancer-related death worldwide.Despite significant advances in screening,surgical management and adjuvant therapies,average 5-year survival seldom exceeds 60%in most developed nations.Metastatic disease represents the primary cause of mortality in patients with CRC,and the liver is the most common location for distant tumour spread.Up to 25%of patients are found to have synchronous liver metastases at the time of diagnosis and a further 30%-40%will develop metachronous disease in the course of follow-up.It has been suggested that primary tumour location[right side versus left side,primary tumour location(PTL)]can influence oncological outcomes in this patient group and that this should be considered in prognostic models and therapeutic decision-making algorithms.This suggestion is not universally accepted and there have been conflicting reports in the literature to date.AIM To provide a comprehensive summary of the available evidence regarding the impact of PTL on oncological outcomes in patients with colorectal cancer liver metastases(CRCLM).METHODS MEDLINE,EMBASE and COCHRANE were searched for relevant publications using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology.Data on oncological outcomes was then extracted from full text articles that met the predefined inclusion criteria.RESULTS A total of 41 studies were identified that met predefined inclusion criteria for this review.In 21 out of 38 studies that provided data on overall survival,a statistically significant improvement in overall survival was reported in patients with left sided primary tumours.These studies included a total of 13897 patients compared with 4306 patients in the studies that did not show a significant difference.Eight studies noted a similar trend towards improved disease-free or progression-free survival.Several authors observed distinct patterns of relapse after treatment of hepatic metastases according to PTL;for example hepatic recurrence after treatment of CRCLM appears to occur more aggressively with right-sided CRC.CONCLUSION Taken together,the findings of the present review indicate that PTL may have a role as an independent prognostic factor when determining treatment and disease surveillance strategies in CRC.The mechanisms responsible for this variation remain poorly understood,but are likely to relate to molecular,histological and embryological differences,as well as inherent differences in therapeutic sensitivity. | George Bingham Alysha Shetye Reena Suresh Reza Mirnezami | 2020 | World Journal of Clinical Oncology2020，11，5： | 3 |
| 2 | Multicarrier modulation for data transmission:An idea whose time has come 显示文摘 | Bingham J A C | 1990 | IEEE Communications Magazine1990，18，5： | 2 |
| 3 | Molecular cloning of complementary DNA to Newcastle disease virus,and nucleotide sequence analysis of the junction between the genes encoding the haemagglutinin-neuramnidase and the large protein显示文摘 | Chambers P Millar N S Bingham R W | | Journal of0，，： | 2 |
| 4 | Breast cancer in a patient with silicone breast implants after 13 years显示文摘 | Bingham HG Copeland EM Hackerr R | 1988 | Ann Plast Surg1988，20，8： | 1 |
| 5 | Registration of alfalfa inbred parental line MAG7显示文摘 | Bingham E T | 1993 | Crop Science1993，33，： | 1 |
| 6 | The genetic control of bud formation from callus of diploid alfalfa显示文摘 | Reish B Bingham E T | 1980 | Plant Science Letters1980，20，： | 1 |
| 7 | Vitrification of toxic wastes:a brief review显示文摘 | Bingham P A and Hand R J | 2006 | Adv Appl Ceram2006，105，： | 1 |
| 8 | Multicarrier modulation for data transmission:an idea whose time has come显示文摘 | Bingham J A C | 1990 | IEEE Commun Magazine1990，28，5： | 1 |
| 9 | Robust magnetic bearing control using stabilizing dynamical compensators显示文摘 | DUAN Guang-ren WU Zhan-yuan CHRIS BINGHAM | 2000 | IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS2000，36，6： | 1 |
| 10 | Genetic improvements in winter wheat yields since 1900 and associated physiological changes 显示文摘 | AUSTIN R B BINGHAM J BLACKWELL R D | 1980 | J Agric Sci1980，94，： | 1 |
| 11 | Allodynia in rats infected with varicella zoster virus-a smallanimal model for post-herpetic neuralgia显示文摘 | DALZIEL R G BINGHAM S SUTTON D | 2004 | Brain Res BrainRes Rev2004，46，2： | 1 |
| 12 | A dual band terahertz metamatefial absorber 显示文摘 | Hu Tao Bingham C M Pilon D | 2010 | Journal of Physics D: Applied Physics2010，43，22： | 1 |
| 13 | The old order changeth显示文摘 | Tom Bingham | 2006 | Law Quarterly Review2006，，： | 1 |
| 14 | The effect of vitamin D levels on the assessment of disease activity in rheumatoid arthritis显示文摘 | M. J. Higgins S. L. Mackie N. Thalayasingam S. J. Bingham J. Hamilton C. A. Kelly | 2013 | Clinical Rheumatology2013，，6： | 1 |
| 15 | Outcome of the dy- namic helical hip screw system for intertrochanterie hip fractures in the elderly patients 显示文摘 | O'Malley NT Deeb AP Bingham KW | 2012 | Geriatr Orthop Surg Rehabil2012，3，2： | 1 |
| 16 | Recent advances in making nano-sized TiO2 visible-light active through rare-earth metal doping 显示文摘 | Bingham S Daoud W A | 2011 | Journal of Materials Chemistry2011，21，7： | 1 |
| 17 | A fast fixed-point algorithm for independent component analysis显示文摘 | Bingham E Hyvrinen A | 1997 | Neural Computation1997，9，7： | 1 |
| 18 | A metamaterial absorber for the terahertz regime:Design, fabrication and characterization显示文摘 | Tao H Landy N I Bingham C M | 2008 | Optics Express2008，16，10： | 1 |
| 19 | Factorisation and denoising of 0-1 data: a variational approach 显示文摘 | Kaban A Bingham E | 2008 | Neuroncomputing2008，71，： | 1 |
| 20 | Multicarrier modulation for data transmission: An idea whose time has come 显示文摘 | Bingham J A C | 1990 | IEEE Communication Magazine1990，37，5： | 1 |
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