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| 1 | Biomarkers for Parkinson's Disease:Recent Advancement显示文摘As a multi-factorial degenerative disease,Parkinson's disease(PD) leads to tremor, gait rigidity,and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible.Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid,oxidative stress, neuroprotection, and inflammation. Also,biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development. | Sharvari Lotankar Kedar S Prabhavalkar Lokesh K Bhatt | 2017 | Neuroscience Bulletin2017,33,5: | 41 |
| 2 | 人体动态稳定性理论及防跌倒扰动性训练进展显示文摘随着世界范围内老龄化社会问题的日益严重,以及一些有运动障碍的特殊群体的扩大,致使跌倒成为了一个严重的社会问题。人体动态稳定性理论是防跌倒研究的理论基础,目前已经取得了有价值的进展。人体动态稳定性理论不同于静态稳定性理论,后者给出的是人体质心位置与支撑面之间的相对位置关系,而前者增加了人体质心速度的因素,给出的是人体质心位置—速度状态与动态稳定区域之间的关系,可利用稳度来判定人体所处的稳定状态,甚至定量评价人体的动态稳定程度。影响跌倒的主要因素有二:稳度为负和支撑不力。在防跌倒的研究中进行适应性练习可显著地提高滑前稳度和滑后稳度,分别体现了前馈控制和反馈控制对人体动态稳定性的神经生理影响。 | 李世明 Yi-Chung Pai Feng Yang Tanvi Bhatt | 2011 | 体育科学2011,31,4: | 30 |
| 3 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007,26,4: | 20 |
| 4 | 成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。 | Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) | 2007 | 国际脑血管病杂志2007,15,6: | 18 |
| 5 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018,26,2: | 16 |
| 6 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017,25,4: | 15 |
| 7 | Assessment of interobserver variation in Garden classification and management of fresh intracapsular femoral neck fracture in adults显示文摘ObjectiveTo 在如果侧面的看法的增加改变整形外科的外科医生被要求仅仅在 AP 看法上分类 35 大腿骨的颈破裂并且建议管理的分类和管理 plan.MethodsTen ,骨折和管理计划基于 anteroposterior ( AP )看并且也估计的新鲜的大腿骨的颈的花园分类上估计 interobserver 协议计划。当时,一样的电影是在 10 天以后与他们的侧面的看法一起重新显示出。结果与到在二个组之间的分类和管理计划的尊重相比。Interobserver 同意用 Fleiss’ 被计算kappa.ResultsThere 仅仅仅仅在 AP 看法上的花园分类上是一个公平 interobserver 协议(kappa 价值 0.39 ) 它改善了在增加一个侧面的看法以后节制同意(kappa 价值 0.52 ) 。当仅仅在 AP 上的管理计划上的 interobserver 协议有细微改进时,仅仅看(kappa 价值 0.50 ) 并且 AP 与侧面的看法(kappa 价值 0.52 ) 结合了。侧面的看法的补充在 15.42% 盒子中改变了分类并且在 23.14% cases.ConclusionWe 改变了管理计划断定当它毫无疑问在计划大腿骨的颈骨折的治疗有一个角色,那个侧面的看法应该与怀疑的大腿骨的颈骨折在所有病人上习惯性地被获得。 | Amit Aggarwal Mahipal Singh Aditya N Aggarwal Shuchi Bhatt | 2014 | Chinese Journal of Traumatology2014,17,2: | 13 |
| 8 | Effects of mother tree ages, different rooting mediums, light conditions and auxin treatments on rooting behaviour of Dalbergia sissoo branch cuttings显示文摘Dalbergia sissoo Roxb. is one of the promising multipurpose tree species of South Asia. Most of the plantations of D. sissoo from seeds are facing severe threats due to the die-back disease, which ultimately causes death of this potential tree-species within a few months. Vegetative propagation could avoid the die-back disease. Thirty mother trees of different age-groups of D. sissoo were selected for evaluating the rooting behaviour of branch cuttings from D. sissoo as influenced by auxins (IAA or IBA at 100, 200, 500 mg·L-1), ages of mother trees (10, 4 and 2 years old) and different environment conditions, i.e., different mediums (soil and sand) or light conditions (in shade and open condition). The results show that application of IAA and IBA induced more numbers of cuttings (collected from 10-year-old mother trees) to root compared to control. Branch cuttings of D. sissoo collected from 10-year-old mother trees and planted in soil bed in open conditions had 100.0% of cuttings to root in IAA (100 mg·L-1) and IBA (200 mg·L-1) treatments. Both rooting medium (Soil and sand) influenced significantly (p<0.05) on rooting response of branch cuttings. Soil medium was found to achieve maximum no. of branch cuttings to root, compared to sand medium. | Bhupendra Singh Rajendra Yadav B. P. Bhatt | 2011 | Journal of Forestry Research2011,22,1: | 12 |
| 9 | Magnetic anchor guidance for endoscopic submucosal dissection and other endoscopic procedures显示文摘Endoscopic submucosal dissection(ESD) is a wellestablished, minimally invasive treatment for superficial neoplasms of the gastrointestinal tract. The universal adoption of ESD has been limited by its slow learning curve, long procedure times, and high risk of complications. One technical challenge is the lack of a second hand that can provide traction, as in conventional surgery. Reliable tissue retraction that exposes the submucosal plane of dissection would allow for safer and more efficient dissection. Magnetic anchor guided endoscopic submucosal dissection(MAGESD) has potential benefits compared to other current traction methods. MAG-ESD offers dynamic tissue retraction independent of the endoscope mimicking a surgeon's 'second hand'. Two types of magnets can be used: electromagnets and permanent magnets. In this article we review the MAG-ESD technology, published work and studies of magnets in ESD. We also review the use of magnetic anchor guidance systems in natural orifice transluminal endoscopic surgery and the idea of magnetic non-contact retraction using surface ferromagentization. We discuss the current limitations, the future potential of MAG-ESD and the developments needed for adoption of this technology. | Mohamed Mortagy Neal Mehta Mansour A Parsi Seiichiro Abe Tyler Stevens John J Vargo Yutaka Saito Amit Bhatt | 2017 | World Journal of Gastroenterology2017,23,16: | 12 |
| 10 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018,26,9: | 11 |
| 11 | 氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较 | Bhatt D.L. Fox K.A.A. Hacke W. E.J. Topol 罗亮 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006,0,7: | 9 |
| 12 | Variation in Polyphenolics and Antioxidant Activity of Traditional Apple Cultivars from West Himalaya,Uttarakhand显示文摘Apple(Malus × domestica) is largely known for polyphenolic and antioxidant properties; however, systematic investigation in the apple growing in the Indian Himalayan region is not carried out. The present study therefore, attempts to quantify polyphenolics and antioxidant activities in three traditional apple cultivars namely 'Benoni', 'Fanny' and 'Rymer' growing at different locations of Uttarakhand(west Himalaya), India.Results revealed that phenolic(0.94–7.00 mg GAE·g^(-1)FW), flavonoid(1.02–9.86 mg QE·g^(-1)FW), flavonol(0.77–6.92 mg CE·g^(-1) FW), tannin(15.49–37.99 mg TAE·g^(-1) FW) and antioxidant activity(ABTS, 3.10–67.36; DPPH, 4.99–14.06; FRAP, 4.70–39.21 mmol AAE·kg^(-1)FW) varied significantly among the cultivars and maximum content was recorded in Rymer fruits of Mukhwa location. Altitude showed significant(P < 0.05) positive relationship with total phenolic(r = 0.895), flavonoid(r = 0.843), flavonol(r = 0.812), ABTS(r = 0.856) and FRAP activity(r = 0.830). Based on the results, it is concluded that among three cultivars, Rymer is one of the most promising sources of polyphenolic content and antioxidant activity and therefore, recommended for mass plantation at suitable locations in Uttarakhand for harnessing maximum potential. | BAHUKHANDI Amit DHYANI Praveen BHATT Indra D. RAWAL Ranbeer S. | 2018 | Horticultural Plant Journal2018,4,4: | 7 |
| 13 | 普拉格雷临床价值分析显示文摘·对于非常可能实施PCI的急性冠脉综合征患者,普拉格雷治疗的效果较好,比如ST段抬高的心肌梗死患者,或者冠脉造影显示无ST段抬高的心肌梗死患者。·老年患者应避免使用,除非有高危因素。·低体重患者可选择低维持剂量,但还需要进一步证实。·无ST段抬高的心肌梗死患者急诊常规选择普拉格雷还为时尚早。·急性冠脉综合征患者初始治疗选择普拉格雷的疗效还不明确,但已在研究之中。·复杂选择性PCI之后常规使用普拉格雷是有临床需求的,但在有进一步的证据之前还不宜使用。 | Deepak L. Bhatt 海燕 | 2009 | 中国处方药2009,8,9: | 6 |
| 14 | Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces显示文摘All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come. | Tarun Bhatt Aditi Sharma Sanjeev Puri Anu Priya Minhas | 2020 | Rice science2020,27,5: | 6 |
| 15 | 妊娠期高血压疾病对远期心血管病的影响显示文摘对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。 | 周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D Bhatt DL Scott NS Peloso GM Natarajan P | 2020 | 中华高血压杂志2020,28,2: | 6 |
| 16 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007,26,1: | 5 |
| 17 | 全球动脉粥样硬化血栓形成门诊患者中心血管危险因素的患病率、认知和治疗显示文摘Context: Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. Objective: To determine whether atherosclerosis risk factor prevalence and treatment would demonstrate comparable patterns in many countries around the world. Design, Setting, and Participants: The Reduction of Atherothrombosis for Continued Health(REACH) Registry collected data on atherosclerosis risk factors and treatment. A total of 67 888 patients aged 45 years or older from 5473 physician practices in 44 countries had either established arterial disease(coronary artery disease[CAD], n=40 258; cerebrovascular disease, n=18843; peripheral arterial disease, n=8273) or 3 or more risk factors for atherothrombosis(n=12 389) between 2003 and 2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, medication use, and degree of risk factor control. Results: Atherothrombotic patients throughout the world had similar risk factor profiles: a high proportion with hypertension(81.8% ), hypercholesterolemia(72.4% ), and diabetes(44.3% ). The prevalence of overweight(39.8% ), obesity(26.6% ), and morbid obesity(3.6% ) were similar in most geographic locales, but was highest in North America(overweight: 37.1% , obese: 36.5% , and morbidly obese: 5.8% ; P< .001 vs other regions). Patients were generally undertreated with statins(69.4% overall; range: 56.4% for cerebrovascular disease to 76.2% for CAD), antiplatelet agents(78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAD), and other evidence-based risk reduction therapies. Current tobacco use in patients with established vascular disease was substantial(14.4% ). Undertreated hypertension(50.0% with elevated blood pressure at baseline), undiagnosed hyperglycemia(4.9% ), and impaired fasting glucose(36.5% in those not known to be diabetic) were common. Among those with symptomatic atherothrombosis, 15.9% had symptomatic polyvascular disease. Conclusion: This large, international, contemporary database shows that classic cardiovascular risk factors are consistent and common but are largely undertreated and undercontrolled in many regions of the world. | Bhatt D.L Gabriel Steg P Magnus Ohman E. 黄浙勇 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006,2,5: | 5 |
| 18 | Therapeutic potential of snake venom in cancer therapy:current perspectives显示文摘Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer.Snake venom toxins coutributed significantly to the treatment of many medical conditions.There are many published studies describing and elucidating the anti-cancer potential of snake venom.Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species.Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes,affecting the migration and proliferation of these cells.Some of substances found in the snake venom present a great potential as anti-tumor agent.In this review,we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity. | Vivek Kumar Vyas Keyur Brahmbhatt Hardik Bhatt Utsav Parmar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013,3,2: | 5 |
| 19 | Bird assemblages in natural and urbanized habitats along elevational gradient in Nainital district (western Himalaya) of Uttarakhand state, India显示文摘 | Dinesh BHATT Kamal Kant JOSHI | 2011 | Current Zoology2011,57,3: | 5 |
| 20 | 缺血性脑卒中患者血压与住院临床结局的相关性显示文摘高血压是脑卒中的主要危险因素。研究表明,在缺血性脑卒中患者中,由于压力依赖性的脑血液流向缺血区域,脑卒中后高血压有益。然而,其他研究显示,脑卒中后的高血压与短期再发性脑卒中、脑出血性转化和脑水肿发生率升高有关。关于血压与脑卒中短期临床结局相关性的观察性研究结论相互矛盾。此外,关于血压的搏动组分(脉压)或稳定组分(平均动脉压)与临床结局相关性的数据有限。 | Bangalore S Schwamm L Smith EE Hellkamp AS Suter RE Xian Y Schulte PJ Fonarow GC Bhatt DL 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017,25,11: | 5 |