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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 3 | 碘乙酰胺诱导的大鼠胃炎中神经肽免疫阳性神经纤维的变化显示文摘目的:探讨含不同神经肽的神经纤维在碘乙酰胺诱导的大鼠胃炎中的变化,分析神经纤维与免疫细胞的相互关系。方法:采用碘乙酰胺诱导制备大鼠胃炎模型,以纯净水喂养为对照组,采用免疫组织化学法、免疫细胞化学法定量分析对照组及模型组大鼠胃黏膜中含P物质(SP)、神经肽Y(NPY)及血管活性肠肽(VIP)的神经纤维数量及免疫活性细胞。结果:光学显微镜观察模型组和对照组胃黏膜含SP、NPY及VIP神经纤维分布于黏膜层腺体之间。模型组黏膜含SP及VIP的神经纤维数量较对照组明显增加(P<0.05)。模型组大鼠的胃黏膜可见免疫活性细胞,主要为淋巴细胞、浆细胞和肥大细胞,表明SP、NPY表现出免疫活性,免疫细胞与神经纤维毗邻。结论:胃炎模型制作成功;神经肽参与了胃炎的形成过程及免疫调节。 | 陈丽萍 吴山力 Fehēr Erzsēbet Altdorfer Károly 迟宝荣 | 2007 | 吉林大学学报(医学版)2007，33，1： | 5 |
| 4 | Protective effect of Nigella sativa oil against binge ethanolinduced oxidative stress and liver injury in rats显示文摘AIM: Nigella sativa L.(Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil(NSO) pretreatment on ethanol-induced hepatotoxicity in rats. METHOD: Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg-1, orally for 3 weeks, followed by oral ethanol(EtOH) administration(5 g·kg-1) every 12 h three times(binge model). RESULTS: Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde(MDA) levels. It decreased hepatic glutathione(GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO(5.0 mL·kg-1) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. CONCLUSION: NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration. | Seval Develi Betül Evran Esra Betül Kalaz Necla Koak-Toker Gül zdemirler Erata | 2014 | Chinese Journal of Natural Medicines2014，12，7： | 4 |
| 5 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 6 | Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors显示文摘AIM:To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90(90 Y) spheres.METHODS:From September 2003 to January 2012,379 procedures of liver radioembolization(RE) using resin microspheres loaded with 90 Y were performed in our center.We have retrospectively compiled the data from 379 RE procedures performed in our center.We report a comprehensive clinical,analytical,endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the treatment.RESULTS:Six patients(1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after RE.The mean time between RE and the appearance of symptoms was 5 wk.Only one patient required endoscopic and surgical treatment.The incidence of gastrointestinal ulcerations was 3.75%(3/80) when only planar images were used for the pre-treatment evaluation.It was reduced to 1%(3/299) when singlephoton emission computed tomography(SPECT) images were also performed.The symptoms that lasted for a longer time were nausea and vomiting,until 25 mo after the treatment.CONCLUSION:All patients were free from severe symptoms at the end of follow-up.The routine use of SPECT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 90 Y particles. | Iago Rodríguez-Lago Cristina Carretero Maite Herráiz José C Subtil Maite Betés Macarena Rodríguez-Fraile Jesús J Sola José I Bilbao Miguel Muoz-Navas Bruno Sangro | 2013 | World Journal of Gastroenterology2013，19，19： | 2 |
| 7 | Risks and Predictors of Blood Transfusion in Pediatric Patients Undergoing Open Heart Operations显示文摘 | Andrea Székely Zsuzsanna Cserép Erzsébet Sápi Tamás Breuer Csaba A. Nagy Péter Vargha István Hartyánszky András Szatmári András Treszl | 2009 | The Annals of Thoracic Surgery2009，，1： | 2 |
| 8 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 9 | Port-compatibility and Connectability Based Assembly Design显示文摘 | Singh P Betting B | 2004 | Journal of Computing and Information Science in Engineering2004，4，3： | 1 |
| 10 | Electronic Conduction in Inxulators at Extreme Field Strengths显示文摘 | Guenth rschulze A Bets H | 1994 | ibit1994，91，： | 1 |
| 11 | Calcium and cardiac rhythms:physiological and pathophysio- logical显示文摘 | Bets DM | 2002 | Circ Res2002，90，1： | 1 |
| 12 | All-Trans and 9-cis retinoid acids inhibit proliferation, migration,and synthesis of extracellular ma- trix of human vascular smooth muscle cells by inducing differentiation显示文摘 | Johst U Bet SA Wiskirchen J | 2003 | J Cardiovasc Phar- macol2003，41，4： | 1 |
| 13 | Formation and transformation of binary intermetallic phases in high purity Al-Fe alloys显示文摘 | Griger A Stefániay Vilmos Kovács-Csetényi Erzsébet | | 0，，： | 1 |
| 14 | Cortical reorganization in children with unilateral sensorinenzal hearing loss显示文摘 | Schmithorst VJ Holland SK Bet J | 2005 | Neuroreport2005，16，： | 1 |
| 15 | Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats显示文摘 | Yang GY Bets AL Chenevert TL | 1994 | J Neurosurg1994，81，1： | 1 |
| 16 | Effects of drying conditions, final moisture content and degree of milling on rice flavor显示文摘 | Elaine T Champagne Karen L Bet Bryan T | 1997 | Cereal Chemistry1997，74，5： | 1 |
| 17 | Supersonic separator gains market acceptance 显示文摘 | Betting M Epsom H D | 2007 | Worm Oil2007，254，： | 1 |
| 18 | EEG features in idiopathic generalized epilepsy:clues to diagnosis显示文摘 | Betting LE Mory SB Lopes-Cendes I | 2006 | Epilepsia2006，47，3： | 1 |
| 19 | Cardiac excitation-contraction coupling显示文摘 | Bets DM | 2002 | Nature2002，415，6868： | 1 |
| 20 | 3D-2D projective registration of free-form curves and surfaces显示文摘 | FELDMAR J AYACHE N BETTING F | 1997 | Comput Vis Image Underst1997，65，3： | 1 |
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