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| 1 | Histological Studies of Atrazine Toxicity on the Thyroid Gland in Rats显示文摘Little is known about the toxic activity of the atrazine (a herbicide, commonly used in agricultural production) on the thyroid gland. In this study the compound was administered orally in female albino rats at sublethal exposure equivalent to 0.2 LD50 doses for 6 and 12 days. At termination of dosing the anesthetized animals were killed and blood was drawn for the determination of serum triiodothyronine (T3) and thyroxin (T4). A dose-dependent decrease of serum T3 concentration was observed in all the groups (control: 0.57 nmol·L-1; 6 days: 0.35 nmol·L-1; 12 days: 0.21 nmol·L-1). The thyroid gland was examined light-microscopically. Bouin’s solution-fixed thyroids were embedded in paraffin and sections cut at 6 μm, stained separately with toluidine blue according to Slinchenko’s method. Histologically in experimental groups epithelium featured small cuboidal cells and occasional structures of the follicles confluence within epitheliomers. A dose-dependent changes of the following parameters were observed: (a) increasing of number of follicle-building thyroid cells; (b) increasing of follicular volume, (c) decreasing of nucleus volume. Investigation of the whole population of thyroid mast cells disclosed no change in degranulation intensity. By contrast, degranulation intensity was decreased in perifollicular mast cells from groups treated with atrazine in dose-dependent manner.There are no changes observed in degranulation of stromal mast cells. These results suggesting that differences in response to the atrazine might account for an aspect of the functional heterogeneity within the rat thyroid mast cell population. | I. N. KORNILOVSKAYA M. V. GORELAYA V. S. USENKO L. V. GERBILSKY AND V. A. BEREZIN(Dept. of Histology, Dniepropetrovsk Medical Institute, Dept. of Biochemistry, Dniepropetrovsk State University, Gagarin Ave. 72,Dniepropetrovsk 320625,Ukraine) | 1996 | Biomedical and Environmental Sciences1996，9，1： | 4 |
| 2 | Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system显示文摘 | Huizingu J D Berezin I Sircar K | 2001 | Gastroenterology2001，120，2： | 2 |
| 3 | High sensitive methane analyzer based on tuned near infrared IR diode laser显示文摘 | Nadezhdinskii A Berezin A Chernin S | 1999 | Proceedings of SPIE1999，3758，： | 2 |
| 4 | Pacemaker activity recorded in interstitial cells of Cajal of the gastrointestinal tract显示文摘 | Barajas-Lopez C Berezin I Daniel EE | 1989 | Am J Physiol1989，257，： | 1 |
| 5 | Generation of slow waves in membrane potential is an intrinsic property of interstitial cellsof Cajal显示文摘 | Lee JC Thuneberg L Berezin I | 1999 | AmJ physio1999，277，： | 1 |
| 6 | Relative role ot up- stream regulators of Akt, ERK and CREB in NCAM- and FGF2-mediated signalling显示文摘 | Ditlevsen D K Owczarek S Berezin V | 2008 | Neurochem Int2008，53，5： | 1 |
| 7 | Effect of long-term treatment with enalapril, losartan and their combination on the quality of life of patients with congestive heart failure显示文摘 | Vizir VA Berezin AE | 2002 | Ter Arkh2002，74，1： | 1 |
| 8 | Non - thermal plasma techniques for the reduction of volatile organic compounds in air streams : a critical review 显示文摘 | Vercammen K L L Berezin A A Lox F | 1997 | Journal of Advanced Oxidation Tech- nologies1997，2，2： | 1 |
| 9 | Generation of slow waves in membrane potential is an instransic property of interstitial cells of cajal显示文摘 | Lee JC Thuneberg L Berezin I | 1999 | Am J Physiol1999，227，40： | 1 |
| 10 | Acinetobacter sppasnosocomial pathogens microbiological, clinical and epidemiological features 显示文摘 | Bergogne Berezin E Towner KJ | 1996 | Clin Microbiol Rev1996，9，： | 1 |
| 11 | Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal显示文摘 | Lee JC Thuneberg L Berezin I | 1999 | Am J Physiol1999，277，21： | 1 |
| 12 | Incidence and clini-cal characteristics of the infection by the respiratory syncytialvirus in children admitted in Santa Casa de Sao Paulo Hospital显示文摘 | Pecchini R Berezin EN Felicio MC eiaZ | 2008 | Braz J Infect Dis2008，12，： | 1 |
| 13 | Circulating osteopontin as a marker of early coronary vascular calcification in type two diabetes mellitus pa- tients with known asymptomatic coronary artery disease 显示文摘 | Berezin AE Kremzer AA | 2013 | Athero- sclerosis2013，229，2： | 1 |
| 14 | Pacemaker activity recorded in interstitial cells of Cajal of the gastrointestinal tract显示文摘 | Barajas- Lopez C Berezin I Daniel EE | 1989 | Am J Physiol1989，257，41： | 1 |
| 15 | Losartan in therapy of chronic heart failure显示文摘 | Vizir VA Berezin AE | 2000 | Klin Med (Mosk)2000，78，2： | 1 |
| 16 | Prolactinoma in 53 men: clinical characteristics and modes of treatment (male prolactinoma) 显示文摘 | Berezin M Shimon I Hadani M | 1995 | J Endocrinol Invest1995，18，6： | 1 |
| 17 | A simple procedure for morphometric analysis of processes and growth cones of neurons in culture using parameters derived from the contour and convex hull of the object显示文摘 | Kava A Stahlhut M Berezin A | 1998 | Journal of Neuroscience Methods1998，79，： | 1 |
| 18 | Brain Research显示文摘 | Kφhler L B Berezin Vladimir Bock Elisabeth Milena Penkowa | 2003 | 992(1): 1282003，992，1： | 1 |
| 19 | Signaling mecha- nisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin 显示文摘 | Hansen SM Berezin V Bock E | 2008 | Cell Mol Life Sci2008，65，23： | 1 |
| 20 | Destruction of volatile organic compounds used in a semiconductor industry by a capillary tube discharge reactor 显示文摘 | KOHNO H BEREZIN A A CHANG J S | 1998 | IEEE Transactions on Industry Application1998，34，5： | 1 |
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