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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 3 | Atopic eczema treatment now and in the future:Targeting the skin barrier and key immune mechanisms in human skin显示文摘The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects up to 20% of children and 3% of adults worldwide, manifesting as red itchy patches of skin with varying severity. This review aims to investigate the leaky skin barrier and immune mechanisms from the perspective of potential novel treatments. The complexity of atopic eczema as a disease is what makes it difficult to treat. Genome-wide association studies have highlighted possible genetic variations associated with atopic eczema, however in some cases, individuals develop the disease without these genetic risk factors. Loss of function mutations in the filaggrin gene are one of these associations and this is plausible due to its key role in barrier function. The Th2 immune response is the link with regards to the immune mechanisms as atopic inflammation often occurs through increased levels of interleukin(IL)-4 and IL-13. Eczematous inflammation also creates susceptibility to colonisation and damage by bacteria such as Staphylococcus aureus. Potential novel treatments are becoming ever more specific, offering the hope of fewer side effects and better disease control. The best new treatments highlighted in this review target the immune response with human beta defensin 2, phosphodiesterase-4 inhibitors and monoclonal antibodies all showing promise. | David C Bell Sara J Brown | 2017 | World Journal of Dermatology2017，6，3： | 5 |
| 4 | Requirement of the auxin polar transport system in early stages of Arabidopsis floral bud formation显示文摘 | OKADA K UEADA J KOMAKI M K BELL C J SHIMURA Y | 1991 | Plant Cell1991，3，7： | 1 |
| 5 | Patterns of expression of Bax, Bcl-2 and Bcl-x(L) in the implantation site in rat during pregnancy 显示文摘 | CORREIA-DA-SILV BELL S C PRINGLE J H | 2005 | Placenta2005，26，10： | 1 |
| 6 | Visual Interactive Simulation-Histroy,Recent Developments and Major Issues显示文摘 | Robert M O'Keefe | 1987 | Simulation1987，49，3： | 1 |
| 7 | The influence of design, materials and kinematics on the in vitro wear of total knee replacements 显示文摘 | McEwen HM Barnett PI Bell C J | 2005 | J Biomech2005，38，： | 1 |
| 8 | Principles, Mechanisms and Applications of Active Screen Plasma Nitriding显示文摘 | Li C X Bell T | 2003 | Heat treatment of Metals2003，12，1： | 1 |
| 9 | Lithography using ultrathin resist films显示文摘 | See E G Pike C Bell S | 2000 | U J Vac Sci Technol B2000，18，： | 1 |
| 10 | ACR guidance document forsafe MR practices : 2007显示文摘 | Kanal E Barkovich A J Bell C | 2007 | Am J Roentgenol2007，188，6： | 1 |
| 11 | Peanut leaf photosynthetic activity in cool field environments显示文摘 | Bell M J Gillespie T J Roy R C | 1994 | Crop Science1994，34，4： | 1 |
| 12 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 13 | Dangers of bone graft substitutes: lessons from using GeneX 显示文摘 | Saadoun S Macdonald C Bell BA | 2011 | J Neurol Neurosurg Psychiatry2011，82，8： | 1 |
| 14 | Premedication in the United States:A status report显示文摘 | Mayes LC Bell C | 1997 | Anesth Analg1997，84，2： | 1 |
| 15 | The interaction of two parallel non-coplanar identical surface cracks under tension and bending显示文摘 | Moussa W A Bell R Tan C L | 1999 | International Journal of Pressure Vessels and Piping1999，79，3： | 1 |
| 16 | Weight gain and its predictors in Chinese adults 显示文摘 | BELL A C GE K POPKIN B M | 2001 | Int J Obsity2001，25，： | 1 |
| 17 | Prothrombotic and pro-oxidant effects of diet-induced hyperhomo-cysteinemial显示文摘 | SAULS D L ARNOLD E K BELL C W | 2007 | Thromb Res2007，120，1： | 1 |
| 18 | Dietary fiber intakes and insulin requirement in pregnant women with type I diabetes 显示文摘 | KALKWART H J BELL R C KHOURY J C | 2001 | J Am Diet Assoc2001，101，3： | 1 |
| 19 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Application Microbiology1967，15，： | 1 |
| 20 | 显示文摘 | Hammond P J Bell A P Hall C D | 1983 | J Chem Soc Perkin Trans 11983，，4： | 1 |
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