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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | 年龄相关性线粒体功能障碍加速动脉粥样硬化形成显示文摘老化是动脉粥样硬化的最强危险因素之一。然而,老化是否独立于慢性高血脂症而增加动脉粥样硬化的风险尚不清楚。该研究旨在确定高血脂症诱导前的血管老化是否会加速动脉粥样硬化的形成。研究者分析了幼年和老年正常血脂野生型(wild type,WT)、无疾病小鼠的主动脉,发现老化导致白细胞介素(interleukin,IL)6水平升高和线粒体功能障碍,并与线粒体自噬增加和其相关蛋白Parkin增加相关。在主动脉组织培养中,研究者发现随着老化的出现,线粒体功能障碍与IL-6存在正反馈关系。研究者通过诱导低密度脂蛋白受体的肝脏特异性降解,再结合10周的西方食物喂养,在老年和幼年小鼠中诱发急性高血脂症,发现老年WT小鼠的动脉粥样硬化增强。高血脂症进一步降低了老年小鼠的线粒体功能,增加了主动脉中Parkin的水平,但幼鼠则没有。 | 刘青(译) 叶鹏(摘、审校) Tyrrell DJ Blin M Song J Wood S Zhang M Beard DA Goldstein D | 2020 | 中华高血压杂志2020，28，2： | 2 |
| 3 | Multiple exciton generation in semiconductor quantum dots 显示文摘 | Beard M C | 2011 | J Phys Chem Lett2011，2，11： | 1 |
| 4 | Iron isotope biosignatures显示文摘 | Beard B L Johnson C M | 1999 | Science1999，285，： | 1 |
| 5 | High Precision iron isotope measurements of terrestrial and lunar material显示文摘 | Beard B L Johnson C M | 1999 | Geochimica et Cosmochimica Acta1999，63，： | 1 |
| 6 | Identification of gene-selective modulators of the bile acid receptor FXR显示文摘 | Dussault I Beard R Lin M | 2003 | J Biol Chem2003，278，9： | 1 |
| 7 | Non-destructive testing of rock bolts using guided ultrasonic waves显示文摘 | Beard M D Lowe M J S | 2003 | Intl Journal of Rock Mechanics & Mining Science2003，40，： | 1 |
| 8 | Subsidy free pricing of interruptible service contracts 显示文摘 | BEARD T R SWEENEY H GROPPER D M | 1995 | Energy Economics1995，17，1： | 1 |
| 9 | Non-destructive testing ofrock bolts using guided ultrasonic waves显示文摘 | BEARD MD LOWE M J S | 2003 | InternationalJournal of Rock Mechanics and Mining Sciences & Ge-omechanics Abstracts2003，40，4： | 1 |
| 10 | A new under- standing of raindrop shape显示文摘 | Beard K V Bringi V N Thurai M A | 2010 | Atmos Res2010，97，： | 1 |
| 11 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 12 | PbTe colloidal nanocrystals: Synthesis, characterization, and multiple exciton generation显示文摘 | Murphy J E Beard M C Norman A G | 2006 | Journal of the American Chemical Society2006，128，10： | 1 |
| 13 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 14 | Iron isotope fractionation by Fe(Ⅱ) oxidizing photoautotrophic bacteria 显示文摘 | Croal L R Johnson C M Beard B L | 2004 | Geochimica et Cosmochimica Acta2004，68，： | 1 |
| 15 | The mitochondrial genome of the mosquito Anopheles gambiae:DNA sequence,genome organization,and comparisons with mitochondrial sequences of other insects显示文摘 | Beard C B Hamm D M Collins F H | 1993 | Insect Molecular Biology1993，2，2： | 1 |
| 16 | Identification of gene-selective modulators of the bile acid receptor FXR显示文摘 | Dussault I Beard R Lin M | 2003 | J Biol Chem2003，278，9： | 1 |
| 17 | Protection of chickens against highly pathogenic avian influenza virus(H5N2) by recombinant fowlpox viruses显示文摘 | Schnitzlein W M Tripathy D N | 1991 | Avian Dis1991，35，2： | 1 |
| 18 | Biogeochemical cycling of iron isotope显示文摘 | Johnson C M Beard B L | 2005 | Science2005，309，： | 1 |
| 19 | Multiple exciton generation in colloidal silicon nanocrystals显示文摘 | Beard M C Knutsen K P Yu P R | 2007 | Nano Letters2007，7，8： | 1 |
| 20 | Developmentof a guided wave inspection technique for rock bolts显示文摘 | BEARD M D LOWE M JS CAWLEY P | 2002 | Non-Destructive Testing and Condition Monitoring2002，44，1： | 1 |
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