|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | On bend-stretch forming of aluminum extruded tubes -Ⅰ:experiments 显示文摘 | MILLER J E KYRIAKIDES S BASTARD A H | 2001 | International J of Mechanical Sciences2001，，43： | 2 |
| 3 | Gut microbiome in allogeneic hematopoietic stem cell transplantation and specific changes associated with acute graft vs host disease显示文摘Allogeneic hematopoietic stem cell transplantation(aHSCT)is a standard validated therapy for patients suffering from malignant and nonmalignant hematological diseases.However,aHSCT procedures are limited by potentially life-threatening complications,and one of the most serious complications is acute graft-versus-host disease(GVHD).During the last decades,DNA sequencing technologies were used to investigate relationship between composition or function of the gut microbiome and disease states.Even if it remains unclear whether these microbiome alterations are causative or secondary to the presence of the disease,they may be useful for diagnosis,prevention and therapy in aHSCT recipients.Here,we summarized the most recent findings of the association between human gut microbiome changes and acute GVHD in patients receiving aHSCT. | Quentin Le Bastard Patrice Chevallier Emmanuel Montassier | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 4 | Eicosapentaenoic acid induces mRNA expression of peroxisome proliferatoractivated receptor gamma 显示文摘 | Chambrier C Bastard J P Rieusset J | 2002 | Obes Res2002，10，6： | 1 |
| 5 | Elevated levels of interleukin- 6 are reduced in serum and subcutaneous adipose tissue of obese women after weig ht loss显示文摘 | Bastard JP Jardel C Bruckert E | 2000 | J Clin Endocrinol Metab2000，85，9： | 1 |
| 6 | Adipose tissue IL - 6content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro显示文摘 | Bastard JP Maachi M Van Nhieu JT | 2002 | J Clin Endocrinol Metab2002，87，5： | 1 |
| 7 | Impact of energy storage costs on economical per- formance in a distribution substain 显示文摘 | FOUAD ABOU CHACRA PATRICK BASTARD GILLES FLEURY | 2005 | IEEE Transactions On Power Systems2005，20，2： | 1 |
| 8 | The metabolically healthy but obese individual presents a favorable inflammation profile 显示文摘 | Karelis A D Faraj M Bastard J P | 2005 | J Clin Endocrinol Metab2005，90，7： | 1 |
| 9 | Hypodiploidy is a major pronostic factor in multiple myeloma显示文摘 | Smadja NV Bastard C Brigaudeau C | 2001 | Blood2001，98，： | 1 |
| 10 | A transformer model for winding fault studies显示文摘 | Bertrand P Meunier M | 1994 | IEEE Transactions on Power Delivery1994，9，2： | 1 |
| 11 | Concunent activation of MYC and bcl-2 in B cell non- Hodgkin's lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus 显示文摘 | Dyer M J Lillington D M Bastard C | 1996 | Leukemia1996，10，7： | 1 |
| 12 | Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte:prevention by rosiglitazone显示文摘 | Lagathu C Bastard JP Auclair M | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 13 | Im-pact of energy storage costs on economical perform-ance in a distribution substation显示文摘 | CHACRA F A BASTARD P FLEURY G | 2005 | IEEE Transac-tions on Power Systems2005，20，2： | 1 |
| 14 | Theoretical investigations of superlattice band structure in the envelope-function approximation显示文摘 | Bastard G | | 0，，： | 1 |
| 15 | TET2 and DNMT3A mutations in human T-cell lymphoma显示文摘 | Couronn~ L Bastard C Bernard OA | 2012 | N Engl J Med2012，366，1： | 1 |
| 16 | The role of interleukins in insulin resistance and type 2 diabetes mellitus显示文摘 | Feve B Bastard JP | 2009 | Nat Rev Endocrinol2009，5，6： | 1 |
| 17 | Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte, prevention by rosiglitazone显示文摘 | Lagathu C Bastard JP Auclair M | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 18 | Onbend-stretch forming of aluminum extruded tubes-1 :Experiments显示文摘 | MILLER J E KYRIAKIDES S BASTARD A H | 2001 | International Journal of MechanicalSciences2001，43，： | 1 |
| 19 | Recent advances in the relationship between obesity, inflammation, and insulin resistance 显示文摘 | Bastard JP Maachi M Lagathu C | 2006 | Eur Cytokine Netw2006，17，1： | 1 |
| 20 | Primary plasma cell leukemia and multiple myeloma: one or two diseases according to the methodology显示文摘 | Smadja NV Bastard C Brigaudeau C | 1999 | Blood1999，94，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员