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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Risk-based inspection planning applied to 14 steel jacket structures显示文摘 | Barton A D Descamps B | 2001 | International Journal of Offshore and Polar Engineering2001，11，1： | 2 |
| 3 | Fate of metals in waste combustion systems 显示文摘 | Barton R G Clark W D Seeker W R | 1990 | Combustion Science and Technology1990，74，： | 1 |
| 4 | Recognition and reaction of metallointercalators with DNA显示文摘 | ERKKILA K E ODOM D T BARTON J K | 1999 | Chem Rev1999，99，： | 1 |
| 5 | A predictive tool to evaluate disc brake squeal propensity, Part 2: System linearization and modal analysis显示文摘 | LEE Y S BROOKS P C BARTON D C | 2003 | International Journal of Vehicle Design2003，31，： | 1 |
| 6 | Pseudorapidity and centrality dependence of the collective flow of charged particles in Au + Au colli- sions at √SNN = 130 GeV显示文摘 | Back B B Baker M D Barton D S | 2002 | Phys Rev Lett2002，89，22： | 1 |
| 7 | Comparative wear under four different tribological conditions of acetylene enhanced cross-linked ultra high molecularweight polyethylene显示文摘 | Marrs H Barton D C Jones R A | 1999 | J Mater Sci:Mater Med1999，10，： | 1 |
| 8 | Effects of Soil Conservation Measures on Erosion Rates and Crop Productivity on Subtropical Ultisols in Yunnan Province,China显示文摘 | BARTON A P FULLEN M A MITCHELL D J | 2004 | Agriculture Ecosystems and Environment2004，104，2： | 1 |
| 9 | Pattern and consequences of interspecific competition in natural communities:a review of field experiments with plants显示文摘 | Goldberg D E Barton A M | 1992 | American Naturalist1992，139，： | 1 |
| 10 | Diabetic ketoacidosis in pregnanacy显示文摘 | Kamalakannan D Baskar V Barton DM | 2003 | Postgrad Med J2003，79，934： | 1 |
| 11 | Transmission line resistance compression networks and applications to wireless power transfer显示文摘 | BARTON T W GORDONSON J M PERREAULT D J | 2015 | IEEE Journal of Emerging and Selected Topics in Power Electronics2015，3，1： | 1 |
| 12 | The factory as learning laboratory 显示文摘 | LEONARD BARTON D | 1992 | Sloan Management Review1992，，： | 1 |
| 13 | Core capability and core rigidities 显示文摘 | Leonard - Barton D | 1992 | Journal of Scientific & Industrial Research1992，2，： | 1 |
| 14 | A novel method of evaluating the impact of secondary brain insuhs on functional outcomes in traumatic brain-injured patients显示文摘 | BARTON CW HEMPHILL JC MORABITO D | 2005 | Acad EmergMed2005，12，1： | 1 |
| 15 | Singlequantum well InGaN green light emitting diode degradation under high electrical stress显示文摘 | BARTON D L OSINSKI M PERLIN P | 1999 | Microelectronics Reliability1999，39，8： | 1 |
| 16 | MicroRNA control of PHABULOSA in leaf development:importance of pairing to the mieroRNA 5' region 显示文摘 | Mallory A C Reinhart B J Jones-Rhoades M W Tang G L Zamore P D Barton M K Barrel D P | 2004 | The EMBO Journal2004，23，： | 1 |
| 17 | Experience with water system closure at recycled paperboard mills显示文摘 | BARTON D A | 1996 | Tappi Journal1996，79，3： | 1 |
| 18 | Core Capability&Core Rigidities 显示文摘 | D L Barton | 1992 | Journal of Scientific&Industrial Research1992，106，13： | 1 |
| 19 | Core capabilities und core rigidity: a paradox in managing new product development 显示文摘 | Leonard - Barton D | 1992 | Strategic Management Journal1992，13，5： | 1 |
| 20 | Assessment of disease progress in psoriasis显示文摘 | Marks R Barton SP Shuttleworth D | 1989 | Arch Dermatol1989，125，20： | 1 |
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