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	题名	作者	年代	出处	被引量
1	Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression.	Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini	2010	World Journal of Gastroenterology2010，16，3：	6
2	Blind separtion of sources: Methods, assumptions and application 显示文摘	MANSOUR A BARROS A K OHNISHI N	2000	Special Issue on Digital Signal Processing in IEICE Transactions on Fundamentals of Electronics Communications and Computer Sciences2000，83，8：	1
3	Productivity changes in Portuguese bus companies显示文摘	Barros CP Peypoch N	2010	Transport Policy2010，17，5：	1
4	Fruit and vegetables consumption and gastric cancer: a systematic review and meta-analysis of cohort studies 显示文摘	Lunet N Lacerda-Vieira A Barros H	2005	Nutr Cancer2005，53，1：	1
5	Primary chemotherapy effect in sentinel node detection in breast cancer显示文摘	Vigario A Sapienza M T Sampaio A P Piato J R Barros N Barros A	2003	Clin Nucl Med2003，28，：	1
6	Availability of phosphorus in a Brazilian Oxisol cultivated with Eucalyptus after nine years as influenced by phosphorus-fertilizer source,rate and placement显示文摘	DIAS L E FERNANDEZ J Q P BARROS N F	2001	Communications in soil science and plant analysis2001，32，78：	1
7	An investigation of the differential performance of clones of the aphid Sitobion avenae on two host species显示文摘	BARRO PJ de SHERRATT T N DAVID O	1995	Oecologia1995，104，3：	1
8	Field evaluation and agronomic performance of transgenic wheat显示文摘	F. Barro P. Barceló P. Lazzeri P. Shewry A. Martín J. Ballesteros	2002	Theoretical and Applied Genetics (-)2002，，6：	1
9	Capital mobility in neoclassical models of growth显示文摘	BARRO R MANKIW N M SALA-I-MARTIN X	1995	The American Economic Review1995，85，1：	1
10	Cutaneous myiasis of the breast: mammographic and us features-report of five cases显示文摘	de Barros N D'Avila MS de Pace Bauab S	2001	Radiology2001，218，2：	1
11	Separation of biodiesel and glycerol using ceramic membranes显示文摘	SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T	2010	JournalofMembraneScience2010，352，2：	1
12	The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 aluminium alloys 显示文摘	OLIVEIRA A F Jr de BARROS M C CARDOSO K R TRAVESSA D N	2004	Materials Science and Engineering A2004，379，12：	1
13	Sequential in vitro digestion of uncooked and cooked sorghum maize samples显示文摘	Alexandra N Correia I Barros A	2004	J Agric Food Chem2004，52，：	1
14	Genetic algorithms applied to the selection of principal components显示文摘	Barros A S Rutledge D N	1998	Chemometrics and intelligent laboratory systems1998，40，1：	1
15	Microcalorimetric study of some Amazonian soils显示文摘	Barros N Fejio S Simoni JA	1999	Thermochim Acta1999，，328：	1
16	Carbon emission from hydroelectric reservoirs linked to reservoir age and latitude 显示文摘	Barros N Cole J J Tranvik L J	2011	Nature Geoscience2011，4，9：	1
17	Raman spectrum of graphite foams显示文摘	Barros E B Demir N S Souza Filho AG	2005	Phys Rev B2005，71，16：	1
18	Differential Role of Hippocampal cAMP-Dependent Protein Kinase in Short- and Long-Term Memory显示文摘	Monica R. M. Vianna Luciana A. Izquierdo Daniela M. Barros Patricia Ardenghi Patricia Pereira Cleverson Rodrigues Beatriz Moletta Jorge H. Medina Iván Izquierdo	2000	Neurochemical Research2000，，5：	1
19	Comparison of quality of refined and whale wheat tortillas显示文摘	Barros F Alviola J N Rooney L W	2010	Journal of Cereal Science2010，51，1：	1
20	Evaluating the Efficiency and Productivity of Insurance Companies with a Malmquist Index:A Case Study for Portugal显示文摘	Barros P Barroso N Borges M R	2005	Geneva Papers on Risk and Insurance2005，30，2：	1

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