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| 1 | H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression显示文摘AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents. | Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst | 2008 | World Journal of Gastroenterology2008，14，6： | 17 |
| 2 | Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction 显示文摘 | Yassin M M Harkin D W Barros D'Sa A A | 2002 | World JSurg2002，26，1： | 1 |
| 3 | Primary chemotherapy effect in sentinel node detection in breast cancer显示文摘 | Vigario A Sapienza M T Sampaio A P Piato J R Barros N Barros A | 2003 | Clin Nucl Med2003，28，： | 1 |
| 4 | Photosynthetic performance of two coffee species under drought显示文摘 | Matta F M D Maestri M Barros R S | 1998 | Photosyuthetica1998，，2： | 1 |
| 5 | Do organizational incentives spur innovation?显示文摘 | Barros H M and Lazzarini S G | 2012 | Brazilian Administration Review2012，9，3： | 1 |
| 6 | incidence of postopera- tive residual neuromuscular blockade in the postanaesthesia care unit an observational multicentre study in Portugal 显示文摘 | Esteves S Martins M Barros F | 2013 | Eur J Anaesthesiol2013，30，5： | 1 |
| 7 | Capital mobility in neoclassical models of growth显示文摘 | BARRO R MANKIW N M SALA-I-MARTIN X | 1995 | The American Economic Review1995，85，1： | 1 |
| 8 | Characterization and activity studies of highly heavy metal resistant sulphate-reducing bacteria to be used in acid mine drainage decontamination 显示文摘 | Martins M Faleiro M L Barros R J | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 9 | Expres sion levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha, beta on monocytes from patients with warm autoimmune hemolytic anemia显示文摘 | Barros MM Yamamoto M Figueiredo MS | 2009 | Transfusion2009，49，1： | 1 |
| 10 | A critical overview of the web services choreography description language显示文摘 | Barros A Dumas M Oaks P | 2005 | BPTrends Newsletter2005，，： | 1 |
| 11 | Religion and economy显示文摘 | MCCLEARY R M BARRO R J | 2006 | Economic Perspectives2006，20，2： | 1 |
| 12 | Carbon nanotubes provide self extinguishing grade to silicone-based foams显示文摘 | VERI)EJO R BARROS()-BUJANS F RODRIGUEZ PEREZ M A | 2008 | Journal of Materials Chemistry2008，18，33： | 1 |
| 13 | Separation of biodiesel and glycerol using ceramic membranes显示文摘 | SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T | 2010 | JournalofMembraneScience2010，352，2： | 1 |
| 14 | Biological activities of α-pinene and β-pinene enantiomers 显示文摘 | Rivas da Silva A C Lopes P M Barros de Azevedo MM | 2012 | Molecules2012，17，6： | 1 |
| 15 | The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 aluminium alloys 显示文摘 | OLIVEIRA A F Jr de BARROS M C CARDOSO K R TRAVESSA D N | 2004 | Materials Science and Engineering A2004，379，12： | 1 |
| 16 | 查看详情显示文摘 | Barros V P Faria A L M acLeod T C O | | 0，，： | 1 |
| 17 | Effect of palmitoleic acid on the inflammatory phase of wound healing显示文摘 | E Hatanaka E Weimann M B Barros Silva | 2015 | Febs Journal2015，282，： | 1 |
| 18 | Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies 显示文摘 | Rosa A J Azevedo M Barros M R A | 2007 | J Chromatogr A2007，1141，： | 1 |
| 19 | Design of a fuzzy controller in mobile robotics using genetic algorithms显示文摘 | M Mucientes D L Moreno S Barro | 2007 | Applied Soft Compu- ting2007，7，2： | 1 |
| 20 | Percutaneous ethanol(PEIT) and calcitrol(PCIT) injection therapy are ineffective in treating severe secondary hyperparathyroidism显示文摘 | Barros Gueiros J E Chammas M C Gerhard R | 2004 | Nephrol Dial Transplant2004，19，3： | 1 |
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