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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | 既有建筑绿色化改造技术策略探索显示文摘在过去30年里,中国城镇化加速使得建筑总量快速增长。目前,中国既有建筑物的总建筑面积已超过500亿m2,其中绿色建筑面积仅有1.627亿m2;而绝大部分的非绿色"存量"建筑,都存在资源消耗水平偏高、环境影响偏大、工作生活环境亟需改善、使用功能有待提升等问题。为了借鉴世界范围既有建筑的建筑绿色改造经验及理论成果,2014年11月重庆大学"国家级低碳绿色建筑国际联合研究中心"邀请来自英国、澳大利亚、荷兰、德国和香港地区的近20余位绿色建筑领域世界知名专家以及部分国内专家来渝参加"既有建筑节能改造国际研讨会",认为现今研究建筑绿色改造的发展策略是非常必要的,必须以创新的思路从目标、技术、机制和政策措施等方面推动发展,并描绘出改造的具体蓝图。本文在中国现有研究和研讨会国际专家们的思考与专项讨论的基础上,提出了绿色化改造发展的技术策略。 | Andrew Baldwin 李百战 喻伟 李永强 | 2015 | 城市住宅2015，22，4： | 13 |
| 3 | 连续性肾脏替代治疗体外循环寿命的影响因素分析显示文摘目的研究连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)过程中体外循环压力变化及其它因素对体外循环寿命的影响。方法纳入重症监护室使用行Prismaflex机器治疗的成年患者,总计85名患者,251个滤器,共10322.2h。收集治疗中每分钟体外循环压力数据、治疗参数、实验室数据,分析对体外循环寿命的影响。结果轻度双腔导管出口功能不良事件(access outflow dysfunction,AOD)尚不影响寿命;中重度AOD事件在不同抗凝亚组中对寿命影响存在差异:发生中重度AOD事件明显缩短无抗凝组、枸橼酸组的寿命(t值分别为3.179,1.949;P值分别为0.002,0.054);而在低肝/肝素组未观测到影响(t=0.630,P=0.950)。通过体外循环寿命的多因素COX模型分析,提示中重度AOD事件是其危险因素(β=0.638,HR=1.893,95%CI:1.300~2.756,P=0.001),枸橼酸(β=-0.906,HR=0.404,95%CI:0.304~0.537,P<0.001)及CVVHDF(β=-0.722,HR=0.486,95%CI:0.335~0.704,P<0.001)是保护因素。结论研究提示使用枸橼酸,CVVHDF能有效延长体外循环。当使用枸橼酸、无抗凝时,若发生中重度AOD,应通过调整循环入口的功能状态来延长循环寿命而不是一味提高抗凝强度。 | 李佩芸 林丽 张凌 Ian Baldwin 唐新 关明镜 魏甜甜 程立新 唐雪 代明金 | 2020 | 中国血液净化2020，19，9： | 9 |
| 4 | p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemotherapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases(PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. Immunotherapy is now emerging as a promising treatment modality in the era of personalized anti-cancer therapeutics. In this review, basic knowledge of PAK structure and regulation is briefly summarised and the pivotal role of PAKs in Kras-driven pancreatic cancer is highlighted in terms of tumour biology and chemoresistance. Finally, the involvement of PAKs in immune modulation in the tumour microenvironment is discussed and the potential advantages of targeting PAKs are explored. | Kai Wang Graham S Baldwin Mehrdad Nikfarjam Hong He | 2018 | World Journal of Gastroenterology2018，24，33： | 7 |
| 5 | Silencing NOA1 Elevates Herbivory-Induced Jasmonic Acid Accumulation and Compromises Most of the Carbon-Based Defense Metabolites in Nicotiana attenuata显示文摘Nitric oxide-associated protein 1 (NOA1) is involved in various abiotic stress responses and is required for plant resistance to pathogen infections. However, the role of NOA1 in plant-herbivore interactions has not been explored. We created NOA1-silenced Nicotiana attenuata plants (irNaNOA1). Compared with wild-type (WT) plants, irNaNOA1 plants had highly decreased photosynthesis rates. We further examined various traits important for plant defense against its specialist herbivore Manduca sexta by treating WT and irNaNOA1 plants with mechanical wounding and M. sexta oral secretions (OS). NOA1-silenced plants showed elevated levels of herbivory-induced jasmonic acid (JA), but decreased JA-isoleucine conjugate (JA-Ile) levels. The decreased JA-Ile levels did not result from compromised JAR (jasmonic acid resistant) activity in irNOA1 plants. Moreover, nitrogen-rich defensive compounds, nicotine and trypsin proteinase inhibitors, did not differ between WT and irNaNOA1 plants. In contrast, concentrations of most carbon-based defensive compounds were lower in these plants than in WT plants, although the levels of chlorogenic acid were not changed. Therefore, silencing NOA1 alters the allocation of carbon resources within the phenylpropanoid pathway. These data suggest the involvement of NOA1 in N. attenuata's defense against M. sexta attack, and highlight its role in photosynthesis, and biosynthesis of jasmonates and secondary metabolites. | Hendrik Wünsche Ian T. Baldwin | 2011 | Journal of Integrative Plant Biology2011，53，8： | 6 |
| 6 | Application of robotics in gastrointestinal endoscopy:Areview显示文摘Multiple robotic flexible endoscope platforms have been developed based on cross specialty collaboration between engineers and medical doctors. However, significant number of these platforms have been developed for the natural orifice transluminal endo-scopic surgery paradigm. Increasing amount of evidence suggest the focus of development should be placed on advanced endolumenal procedures such as endoscopic submucosal dissection instead. A thorough literature analysis was performed to assess the current status of robotic flexible endoscopic platforms designed for advanced endolumenal procedures. Current efforts are mainly focused on robotic locomotion and robotic instrument control. In the future, advances in actuation and servoing technology, optical analysis, augmented reality and wireless power transmission technology will no doubt further advance the field of robotic endoscopy. Globally, health systems have become increasingly budget conscious; widespread acceptance of robotic endoscopy will depend on careful design to ensure its delivery of a cost effective service. | Baldwin Po Man Yeung Philip Wai Yan Chiu | 2016 | World Journal of Gastroenterology2016，22，5： | 6 |
| 7 | 关于广义模糊CMAC学习收敛性的理论结果(英文)显示文摘提出了广义模糊 CMAC( cerebellar model articulation controller)神经网络 ,并导出了其学习的充分条件 .最后 ,证明了广义模糊 CMAC在平方误差意义下的学习收敛性 .研究结果为广义模糊 CMAC的广泛应用提供了基础 . | 王士同 Baldwin J.F. Martin T.P. | 2000 | 软件学报2000，11，11： | 6 |
| 8 | The NF-kappa B and I kappa B proteins: new discoveries and insights.显示文摘 | Baldwin AS | | 0，，： | 4 |
| 9 | In vitro and in vivo application of RNA interference for targeting genes involved in peritrophic matrix synthesis in a lepidopteran system显示文摘大多数昆虫的 midgut 与一个半渗透的非细胞组成的试管被衬里, peritrophic 矩阵(下午) ,几丁质和蛋白质镇静。尽管各种各样的基因编码下午蛋白质被描绘了,我们他们在下午结构和功能的角色的理解是很有限的。为获得功能的信息的一条有希望的途径是 RNA 干扰,它被用来减少使用任何一个注射予幼虫以的双 stranded RNA 或喂的特定的 mRNAs 的层次。尽管这个方法很好在 dipterans 和甲虫类之昆虫被记录,它在 lepidopterans 的成功的报告被改变。在当前的学习,编码下午蛋白质的 silencing midgut 基因(昆虫肠的粘蛋白 1 ,昆虫肠的粘蛋白 4 ,下午蛋白质 1 )并且几丁质 biosynthetic 或修改的酶(几丁质 synthase-B 和几丁质 deacetylase 1 )在 noctuid 鳞翅类, Mamestra configurata ,在 vitro 并且在 vivo 被检验。在在主要 midgut 的 vitro 研究,上皮的房间准备揭示了尖锐、快速的 silencing (由 24 h ) 为编码几丁质 deacetylase 的基因 1 并且 silencing 的更慢的率(由 72 h ) 为编码下午蛋白质 1 的基因。肠的粘蛋白是的基因编码昆虫稍微由 72 h 的 silenced,而没有 silencing 为编码几丁质 synthase-B 的基因被检测。在 vivo,实验集中了于几丁质 deacetylase 1 基因是 silenced 到在 vitro 的最大的程度。与双 stranded RNA 的出生不满一月的婴儿和第四个中间形态幼虫的连续的喂导致了几丁质 deacetylase 的 silencing 1 由 24 和 36 h 分别地。喂单个剂量到出生不满一月的婴儿也由 24 h 导致了 silencing。当前的学习证明基因编码下午蛋白质能是为 RNA 干扰由的 silenced 和轮廓条件每在 lepidopterans 喂的 os。 | Umut Toprak Doug Baldwin Martin Erlandson Cedric Gillott Stephanie Harris Dwayne D. Hegedus | 2013 | Insect Science2013，20，1： | 4 |
| 10 | Identification of the Mamestra configurata (Lepidoptera Noctuidae) peritrophic matrix proteins and enzymes involved in peritrophic matrix chitin metabolism显示文摘peritrophic 矩阵(下午) 为昆虫是必要的它由食物粒子,病原体,和毒素保护 midgut 上皮免受损坏的伤害的消化系统生理学。下午也由于它的 per os 可接近性是为新害虫控制策略的开发的一个吸引人的目标。理解 PM 怎么执行这些函数, PM 的分子的体系结构用 genomic 被检验, proteomic 在 Mamestra configurata 来临(鳞翅目:Noctuidae ) ,饰有十字架的 oilseed 的一个主要害虫在北美洲收割。PM 的液体层析双人脚踏车团 spectrometry 分析识别了是分类的 82 蛋白质:(i) peritrophins,与一个 CBDIII 领域包括一个新班;(ii ) 酶在几丁质修正(几丁质 deacetylases ) 包含了,消化(丝氨酸朊酶, aminopeptidases, carboxypeptidases,脂肪分解酵素和 α-amylase ) 或另外的反应(β-1,3-glucanase,碱的磷酸酶, dsRNase,虾红素, pantetheinase ) ;(iii ) 没有已知的 orthologs,由 polycalin, REPAT, serpin, C 类型 lectin 和 Lsti99/Lsti201 和 3 新奇蛋白质组成的一个异质的组。编码下午蛋白质的基因在 midgut 主要被表示。cDNAs 编码几丁质 synthase-2 (McCHS-2 ) , chitinase (McCHI ) ,和 β-N-acetylglucosaminidase (McNAG ) 酶,在下午几丁质新陈代谢包含了,也被识别。McCHS-2 表示对显示它为在 PM,的几丁质合成负责的 midgut 特定在 midgut 的唯一的几丁质的材料。相反,编码 chitinolytic 酶的基因在多重纸巾被表示。McCHS-2, McCHI,和 McNAG 在喂幼虫的 midgut 被表示,并且唠叨活动在 PM 是在场的。这个信息被用来产生鳞翅类的下午建筑学的一个更新的模型。 | Umut Toprak Martin Erlandson Doug Baldwin Steve Karcz Lianglu Wan Cathy Coutu Cedric Gillott Dwayne D. Hegedus | 2016 | Insect Science2016，23，5： | 4 |
| 11 | 四味镇痛中药对内腓肽降解酶作用的实验研究(英文)显示文摘目的 :研究四味镇痛中药对内腓肽降解酶的作用。方法 :从大鼠的肾脏制备含有内腓肽降解酶的物质 ,建立内腓肽降解酶活性检测模型 ;并用此模型观察四味镇痛中药提取物对内腓肽降解酶特别是对中性内肽酶活性 (NEP2 4 .11)的抑制作用。结果 :(1)钩藤和羌活的水提物显示很强的NEP2 4 11酶抑制作用 ;(2 )无论是有机提取物还是水提物 ,延胡索和川芎对NEP2 4 11的抑制作用都弱于钩藤和羌活 ;(3)钩藤和羌活不仅是氨肽酶和中性内肽酶的双重抑制剂 ,而且是氨肽酶、中性内肽酶和血管紧张素转化酶的三重抑制剂。结论 :四味镇痛中药具有不同的镇痛机制 ,其中 。 | 刘碧崇 Stan LAMBERT John BALDWIN H.EVANS | 2002 | 天然产物研究与开发2002，14，4： | 4 |
| 12 | Functional specialization of Nicotiana attenuata phytochromes in leaf development and flowering time显示文摘Phytochromes mainly function in photoautotrophic organisms to adjust growth in response to fluctuating light signals.The different isoforms of plant phytochromes often display both conserved and divergent roles,presumably to fine-tune plant responses to environmental signals and optimize fitness.Here we describe the distinct,yet partially redundant,roles of phytochromes NaPHYA,NaPHYB1 and NaPHYBi in a wild tobacco species,Nicotiana attenuata using RNAi-silenced phytochrome lines.Consistent with results reported from other species,silencing the expression of NaPHYA or NaPHYBi in N.attenuata had mild or no influence on plant development as long as NaPHYBi was functional;whereas silencing the expression of NaPHYBi alone strongly altered flowering time and leaf morphology.The contribution of NaPHYB2 became significant only in the absence of NaPHYB1;plants silenced for both NaPHYBi and NaPHYB2 largely skipped the rosettestage of growth to rapidly produce long,slender stalks that bore flowers early:hallmarks of the shadeavoidance responses.The phenotyping of phytochrome-silenced lines,combined with sequence and transcript accumulation analysis,suggest the independent functional diversification of the phytochromes,and a dominant role of NaPHYBi and NaPHYB2 in N.attenuata's vegetative and reproductive development. | Variluska Fragoso Youngjoo Oh Sang-Gyu Kim Klaus Gase Ian Thomas Baldwin | 2017 | Journal of Integrative Plant Biology2017，59，3： | 4 |
| 13 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | 2001 | Journal of Economic Growth2001，，1： | 3 |
| 14 | Gastrin as an autocrine growth factor in colorectal carcinoma:implications for therapy显示文摘Thereisnowconsiderableexperimentalsupportforthehypothesisthatprogastrinderivedpeptidesstimulateproliferationofthenormalcolon... | Graham S. Baldwin and Arthur Shulkes | 1998 | World Journal of Gastroenterology1998，4，6： | 3 |
| 15 | 21世纪的区域主义——弥合21世纪的贸易与20世纪贸易规则之间的差别显示文摘当今的区域主义从性质上根本不同于上个世纪90年代的区域主义;传统的'垫脚石-绊脚石'理论以及维纳经济学,如今已不再适用于分析全新的区域一体化;相比较20世纪的区域主义,21世纪的区域主义在对世界贸易体系启示方面有着不同的意义。本文旨在依据这些事实提炼出一个论点,从而指引出一条全新的方式来思索当今的区域主义。 | Richard Baldwin 范连颖(摘译) | 2012 | 经济资料译丛2012，，1： | 3 |
| 16 | JA but not JA-Ile is the cell-nonautonomous signal activating JA mediated systemic defenses to herbivory in Nicotiana attenuata显示文摘The whole-plant activation of defense responses to wounding and herbivory requires systemic signaling in which jasmonates(JAs) play a pivotal role. To examine the nature of the slower cell-nonautonomous as compared to the rapid cell-autonomous signal in mediating systemic defenses in Nicotiana attenuata,reciprocal stem graftingexperiments were used with plants silenced for the JA biosynthetic gene ALLENE OXIDE CYCLASE(irAOC) or plants transformed to create JA sinks by ectopically expressing Arabidopsis JA-O-methyltransferase(ovJMT). JA-impaired irAOC plants were defective in the cell-nonautonomous signaling pathway but not in JA transport. Conversely,ovJMT plants abrogated the production of a graft-transmissible JA signal. Both genotypes displayed unaltered cell-autonomous signaling. Defense responses(17-hydroxygeranyllinalool diterpene glycosides,nicotine,and proteinase inhibitors)and metabolite profiles were differently induced in ir AOC and ov JMT scions in response to graft-transmissible signals from elicited wild type stocks. The performance of Manduca sexta larvae on the scions of different graft combinations was consistent with the patterns of systemic defense metabolite elicitations. Taken together,we conclude that JA and possibly Me JA,but not JA-Ile,either directly functions as a long-distance transmissible signal or indirectly interacts with long distance signal(s)to activate systemic defense responses. | Tobit A. Bozorov Son Truong Dinh Ian T. Baldwin | 2017 | Journal of Integrative Plant Biology2017，59，8： | 3 |
| 17 | DICER-like Proteins and Their Role in Plant-herbivore Interactions in Nicotiana attenuata显示文摘DICER-like (DCL) proteins produce small RNAs that silence genes involved in development and defenses against viruses and pathogens. Which DCLs participate in plant-herbivore interactions remains unstudied. We identified and stably silenced four distinct DCL genes by RNAi in Nicotiana attenuata (Torrey ex. Watson), a model for the study of plant-herbivore interactions. Silencing DCL1 expression was lethal. Manduca sexta larvae performed significantly better on ir-dcl3 and ir-dcl4 plants, but not on ir-dcl2 plants compared to wild type plants. Phytohormones, defense metabolites and microarray analyses revealed that when DCL3 and DCL4 were silenced separately, herbivore resistance traits were regulated in distinctly different ways. Crossing of the lines revealed complex interactions in the patterns of regulation. Single ir-dcl4 and double ir-dcl2 ir-dcl3 plants were impaired in JA accumulation, while JA- Ile was increased in ir-dcl3 plants. Ir-dcl3 and ir-dcl4 plants were impaired in nicotine accumulation; silencing DCL2 in combination with either DCL3 or DCL4 restored nicotine levels to those of WT. Trypsin proteinase inhibitor activity and transcripts were only silenced in ir-dcl3 plants. We conclude that DCL2/3/4 interact in a complex manner to regulate anti-herbivore defenses and that these interactions significantly complicate the already challenging task of understanding smRNA function in the regulation of biotic interactions. | Tohir Ahmadovich Bozorov Shree Prakash Pandey Son Truong Dinh Sang-Gyu Kim Maria Heinrich Klaus Gase Ian T. Baldwin | 2012 | Journal of Integrative Plant Biology2012，54，3： | 3 |
| 18 | Circadian clock component, LHY, tells a plant when to respond photosynthetically to light in nature显示文摘The circadian clock is known to increase plant growth and fitness,and is thought to prepare plants for photosynthesis at dawn and dusk;whether this happens in nature was unknown. We transformed the native tobacco,Nicotiana attenuata to silence two core clock components,NaLHY(irLHY) and NaTOC_1(irTOC_1). We characterized growth and light-and dark-adapted photosynthetic rates(A_c) throughout a 24 h day in empty vector-transformed(EV),irLHY,and irTOC_1 plants in the field,and in NaPhy Aand NaPhy B1-silenced plants in the glasshouse. The growth rates of irLHY plants were lower than those of EV plants in the field. While irLHY plants reduced A_c earlier at dusk,no differences between irLHY and EV plants were observed at dawn in the field. irLHY,but not EV plants,responded tolight in the night by rapidly increasing A_c. Under controlled conditions,EV plants rapidly increased A_c in the day compared to dark-adapted plants at night;irLHY plants lost these time-dependent responses. The role of NaLHY in gating photosynthesis is independent of the light-dependent reactions and red light perceived by NaPhy A,but not NaPhyB_1. In summary,the circadian clock allows plants not to respond photosynthetically to light at night by anticipating and gating red light-mediated in native tobacco. | Youngsung Joo Variluska Fragoso Felipe Yon Ian T. Baldwin Sang-Gyu Kim | 2017 | Journal of Integrative Plant Biology2017，59，8： | 3 |
| 19 | THE NF-&kgr;B AND I&kgr;B PROTEINS: New Discoveries and Insights显示文摘 | Albert S. Baldwin | 1996 | Annual Review of Immunology1996，，： | 3 |
| 20 | Narboh D, a Respiratory Burst Oxidase Homolog in Nicotiana attenuata, is Required for Late Defense Responses After Herbivore Attack显示文摘The superoxide (O2-)-generating NADPH oxidases are crucial for the defense of plants against attack from pathogens; however, it remains unknown whether they also mediate responses against chewing insect herbivores. The transcripts of the respiratory burst NADPH oxidase homolog Narboh D in Nicotiana attenuate are rapidly and transiently elicited by wounding, and are amplified when Manduca sexta oral secretions (OS) are added to the wounds. The fatty-acid-amino-acid-conjugates (FACs), demonstrably the major elicitors in M. sexta OS, are responsible for the increase in Narboh D transcripts. Silencing Narboh D significantly reduced reactive oxygen species (ROS) levels after OS elicitation, but neither OS-elicited jasmonic acid (JA) or JA-isoleucine (JA-Ile) bursts, pivotal hormones that regulates plant resistance to herbivores, nor early transcripts of herbivore defense-related genes (NaJAR4 and NaPAL1), were influenced. However, late OS-elicited increases in trypsin proteinase inhibitors (TPIs), as well as the transcript levels of defense genes such as polyphenol oxidase, TPI and Thionin were significantly reduced. In addition, Narboh D-silenced plants were more vulnerable to insect herbivores, especially the larvae of the generalist Spodoptera littoralis. We thus conclude that Narboh D-based defenses play an important role in late herbivore-elicited responses. | Jinsong Wu Lei Wang Hendrik Wunsche lan T. Baldwin | 2013 | Journal of Integrative Plant Biology2013，55，2： | 3 |
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