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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | The injury severity score : a method for describing patients with multiple injuries and evaluating emergency care 显示文摘 | Baker SP O heill B Haddon W Jr | 1974 | J Trauma1974，14，3： | 3 |
| 3 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 4 | Distributed cooperative Web servers显示文摘 | Baker S M Moon B | 1999 | Computer Networks1999，31，1116： | 1 |
| 5 | The evolutionary dynamic of sex determination显示文摘 | MARIN I BAKER B S | 1998 | Science1998，281，5385： | 1 |
| 6 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantails J M Baker N R | 1989 | Biochim Biophys Acta1989，990，： | 1 |
| 7 | Pseudorapidity and centrality dependence of the collective flow of charged particles in Au + Au colli- sions at √SNN = 130 GeV显示文摘 | Back B B Baker M D Barton D S | 2002 | Phys Rev Lett2002，89，22： | 1 |
| 8 | Prevalence of panic disorder in cardiac outpatients显示文摘 | Morris A Baker B Devins GM et a1 | 1997 | Can J Psychiatry1997，42，2： | 1 |
| 9 | The relationship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | Genty B Briantais JM Baker NR | 1989 | Biochim Biophys Acta1989，990，： | 1 |
| 10 | The injury severity score:a method for describing patients with multiple injuries and evaluating emergency care显示文摘 | Baker SP O'Neill B Haddon W | 1974 | J Trauma1974，14，： | 1 |
| 11 | The relationship between the quantum yield of photosynthetic electorn transport and quenching of chloorphyll fluorcscence显示文摘 | Genty B Brianais J M Baker N R | 1989 | Biochim Biophys Acta1989，199，： | 1 |
| 12 | Global Standard for the Composition of Infant Formula : Recommendations of an ESPGHAN Coordinated International Expert Group 显示文摘 | Koletzko B Baker S Cleghorn G | 2005 | Journal of Pediatric Gastroenterology and Nutrition2005，41，： | 1 |
| 13 | Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats 显示文摘 | Baker K B Kim J J | 2002 | Learning and Memory2002，，9： | 1 |
| 14 | An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist,CP-101,606,in patients with treatment-refractory major depressive disorder显示文摘 | Preskorn S H Baker B Kolluri S | 2008 | J Clin Psychopharmacol2008，28，6： | 1 |
| 15 | Ecological risk as- sessment of atrazine in North American surface waters 显示文摘 | Keith R Solomon David B Baker R Pe- ter Richards | 1996 | Environmental Toxi- cology and Chemistry1996，15，1： | 1 |
| 16 | The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severely truncated derivatives of AvrBs4 and overexpressed AvrBs3显示文摘 | Schornack S Ballvora A Gürlebeck D Peart J Ganal M Baker B Bonas U Lahaye T | 2004 | The Plant Journal2004，37，1： | 1 |
| 17 | Marine microbes:invisible nanofactories显示文摘 | Baker S Harini B P Rakshith D | 2013 | J Pharm Res2013，6，3： | 1 |
| 18 | The relationship be-tween the quantum yield of photosynthetic electron transportand quenching of chlorophyll fluorescence 显示文摘 | Genty B E Briantais M J Baker N R | 1989 | BiochemistryBiophysics Acta1989，990，： | 1 |
| 19 | The rdat~onship between the quantum yield of photosynthetic electron transport and quenching of chlorophyll fluorescence显示文摘 | GENTY B BRIANTAIS J M BAKER N R | 1989 | Biochimicaet Biophysiea Aeta1989，990，1： | 1 |
| 20 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care 显示文摘 | Baker SP O'Neill B Haddon WJ | 1974 | Trauma Injury Infect Crit Care1974，14，3： | 1 |
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