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| 1 | Overproduction of reactive oxygen species–obligatory or not for induction of apoptosis by anticancer drugs显示文摘Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species(ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: 'Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?' The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. | Donika Ivanova Zhivko Zhelev Ichio Aoki Rumiana Bakalova Tatsuya Higashi | 2016 | Chinese Journal of Cancer Research2016，28，4： | 3 |
| 2 | Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics显示文摘 | Bakalova R Zhelev Z Kokuryo D | 2011 | Int J Nanomedicine2011，6，： | 1 |
| 3 | 显示文摘 | Zlatilova P Bakalova I | 2002 | J Power Sources2002，112，1： | 1 |
| 4 | Quantum dots as photosensitizers? 显示文摘 | Bakalova R Ohba H Zhelev Z | 2004 | Nat Bioteeh2004，22，11： | 1 |
| 5 | Quantum dots as photosensitizers显示文摘 | Bakalova R Ohba H Zhelev Z | 2004 | Nat Biotechnol2004，22，： | 1 |
| 6 | Synthesis, physicochemical and in vitro pharmacological investigation of new platinum(Ⅱ) complexes with some cycloalkanespiro-5'-hydantoins 显示文摘 | Bakalova A Buyuldiev R Momekov G | 2005 | European J Med Chem2005，40，： | 1 |
| 7 | An effective method for bioconversion of delignified waste-cellulose fibers from the paper industry with a cellulase complex显示文摘 | Todor Nikolov Nadka Bakalova Svetla Petrova | 2000 | Bioresource Technology2000，71，： | 1 |
| 8 | Comparative assessment of the cytotoxic effects of carboxylato-bridged dinuclear platinum (Ⅱ) complexes against human tumor cell lines 显示文摘 | Momekov G Bakalova A Konstantinov S | 2005 | Neoplasma2005，52，6： | 1 |
| 9 | Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation factors (microarray study) 显示文摘 | ZHELEV Z BAKALOVA R OHBA H | 2004 | FEBS Lett2004，570，： | 1 |
| 10 | Towardmarker assisted selection for fungal disease resistance in grapevine显示文摘 | HVARLEVA T BAKALOVA A RUSANOV K | 2009 | Biotechnology & Biotechnological Equipment2009，23，： | 1 |
| 11 | Quantum dots as photosensitizers 显示文摘 | Bakalova R Ohba H Zhelev Z Ishikawa M Baba Y | 2004 | Nature biotechnology2004，22，11： | 1 |
| 12 | Production and characterization of extracellularct-amylase from the thermophilie fugus Thermomyees lanuginosus (wild and mutant strains)显示文摘 | PETROVA S D LLIEVA S Z BAKALOVA N G | 2000 | Bioteehnol Lett2000，22，20： | 1 |
| 13 | Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes显示文摘 | Zhelev Z Ohba H Bakalova R | 2004 | Phenothiazines Leukemia Cancer Chemother Pharmacol2004，53，3： | 1 |
| 14 | Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance ima- ging of blood-brain barrier permeability for conventional therapeutics 显示文摘 | Zhelev Z Bakalova R Aoki 1 | 2009 | Chem Commun2009，7，1： | 1 |
| 15 | Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation (actors (microarray study)显示文摘 | Zhelev Z Bakalova R Ohba H | 2004 | FEBS Lett2004，570，13： | 1 |
| 16 | Novel approaches towards development of non-classical platinum-based antineoplastic agents:Design of platinum complexes characterized by an alternative DNA-binding pattern and/or tumor-targeted cytotoxicity显示文摘 | Momekov G Bakalova A Karaivanova M | 2005 | Curr Med Chem2005，12，： | 1 |
| 17 | Synthesis,XRD characterization,and cycling performance of cobalt doped lithium nickelates显示文摘 | Moshtev R Zlatilov P Bakalova I | | 0，，： | 1 |
| 18 | Novel approaches towards development of non-classical platinum-based antineoplastic agents:design of platinum complexes characterized by an alternative DNA-binding pattern and/or tumor-targeted cytotoxicity显示文摘 | Momekov G Bakalova A Karavanova M | | 0，，19： | 1 |
| 19 | Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes,apoptotic/antiapoptotic genes and cell proliferation factors(microarray study)显示文摘 | Zhelev Z Bakalova R Ohba H | 2004 | FEBS Lett2004，570，13： | 1 |
| 20 | Production and characterization of extracellular α-amylases from the thermophilic fungus Thermomyces lanuginosus (wild and mutant strains)显示文摘 | Petrova S D Ilieva S Z Bakalova N G et a1 | 2000 | Biotechnol Lett2000，22，20： | 1 |
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