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| 1 | Locally transplanted enteric glia improve functional and structural recovery in a rat model of spinal cord injury显示文摘<正>BACKGROUND:We have previously reported that adult enteric glia(EG) facilitate the growth of transected dorsal root axons into the uninjured spinal cord to form functional connections with their targets. OBJECTIVE:The present study investigated the effects of EG on spinal cord function,tissue injury, and axonal regeneration following transplantation into injured rat spinal cords,according to histological and functional outcomes. DESIGN,TIME AND SETTING:A randomized controlled animal experiment was performed at McMaster University,Canada from January 2006 to March 2008. MATERIALS:EG were isolated from rat intestine. METHODS:One week following spinal cord crush,female Wistar rats were injected with an EG suspension(2μL,1×10~5/μL,n=10) or with the same volume of fresh culture medium alone(control animals,n=11).The third group did not receive any injection following laminectomy and served as the sham-operated controls(n=5). MAIN OUTCOME MEASURES:Behavior was tested prior to transplantation and weekly following transplantation,with nine behavioral examinations in total.Open field,hind limb placement response, foot orientation response,and inclined plane test were utilized.Immediately following the final behavioral examination,spinal cord T_9 to L_1 segments were harvested for immunohistochemical and hematoxylin-eosin staining to determine astroglial scarring,axonal regeneration and spinal cord lesion size. RESULTS:Rats with EG transplantation exhibited significantly better locomotor function with reduced tissue damage,compared with the control rats.Cystic cavities were present 2 months after injury in spinal cords from both control groups.In contrast,rats injected with EG did not present with cystic lesions.In addition,the injury site consisted of cellular material and nerve fibers,and axonal regeneration was apparent,with dense labeling of neurofilament-positive axons within the injury site. Moreover,regenerating axons were intimately associated with transplanted EG CONCLUSION:These data indicated that EG enhanced functional improvement,which was associated with reduced tissue damage and axonal regeneration following transplantation into injured spinal cords. | Shucui Jiang Mohammad I. Khan James R. Bain Cai Jiang Christopher R. Hansebout Zesheng Yu Yuqing Liu Michel P, Rathbone | 2009 | Neural Regeneration Research2009，4，9： | 2 |
| 2 | Treatment of ovariectomized rats with strontium ranelate improves bon etrength and bon equality显示文摘 | BAIN S SHEN V HARA P | 2004 | Calcif Tissue Int2004，74，： | 1 |
| 3 | Memory T-cell-mediated immune responses specific to an alternative core protein in hepatitis C virus infection显示文摘 | Bain C Parroche P Lavergne JP | 2004 | J Virol2004，78，10： | 1 |
| 4 | Criteria for the di-agnosis of essential tremor 显示文摘 | Bain P Brin M Deuschl G | 2000 | Neurology2000，54，4： | 1 |
| 5 | Adult height in congentital hypothyroidism: prognostic factors and the importance of compliance with areatment 显示文摘 | Bain P Toublanc JE | 2002 | Hhorm Res2002，58，： | 1 |
| 6 | Energy-storage technologies and electricity generation显示文摘 | HALL P J BAIN E J | 2008 | Energy Policy2008，36，12： | 1 |
| 7 | Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids 显示文摘 | Ochs M M McCusker M P Bains M | 1999 | Antimicrob Agents Chemother1999，43，5： | 1 |
| 8 | Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids 显示文摘 | Ochs M M McCusker M P Bains M | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 9 | Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways显示文摘 | Ping P Baines CP Gu Y | 2003 | Cardiovasc Toxicol2003，3，4： | 1 |
| 10 | The reaction of β-pinene with formaldehyde显示文摘 | BAIN J P NOPOL I | 1946 | J Am Chem Soc1946，，68： | 1 |
| 11 | Functional proteomic,analysis of a three-tier PK cepsilon-akteNOS signaling module in cardiac protection显示文摘 | BAINES C P ZONG C | 2005 | am J Physiol Heart Circ Physiol2005，288，2： | 1 |
| 12 | Mitochondrial PKC εand MAPK form signaling modules in the murine heart (fu :Enhanced Mitochondrial PKCε - MAPK interactions and differential MAPK activation in PKCε- induced cardioprotection显示文摘 | Christorpher P Baines L Zhang J | 2002 | Circulation Research2002，90，4： | 1 |
| 13 | A European consensus report on blood cell identification : terminology utilized and morphological diagnosis concordance among 28 experts from 17 countries within the European LeukemiaNet network WP10, on behalf of the ELN Morphology Faculty 显示文摘 | Zini G Bain B Bettelheim P | 2010 | Br J Haematol2010，151，4： | 1 |
| 14 | On internal generation models显示文摘 | BAINES P G | 1982 | Deep sea Research1982，29，3： | 1 |
| 15 | Angiotensin-re- ceptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy显示文摘 | Barnett AH Bain SC Bouter P | 2004 | N Engl d Med2004，351，19： | 1 |
| 16 | Signal transduction in ischemic preconditioning:The role of kinase and mitochondrial KATP channels显示文摘 | Baines C P Cohen M V Downey J M | 1999 | J Cardiovasc Electrophysiol1999，10，5： | 1 |
| 17 | Aquatic ecosystem protection and restoration:advances in methods for assessment and evaluation显示文摘 | Bain M B Harig A L Loucks D P | 2000 | Environmental Science & Policy2000，，3： | 1 |
| 18 | Laccase from a non-melanogenic, alkalotolerant gamma-proteobacterium JB isolated from industrial wastewater drained soil 显示文摘 | Bains J Capalash N Sharma P | 2003 | Biotechnology ltters2003，25，14： | 1 |
| 19 | Down by the Riverside:Ur- ban Riparian Ecology显示文摘 | Groddman P M Bain D J Band L E | 2003 | Frontiers in Ecology and the Environment2003，，6： | 1 |
| 20 | Randomised trial of interferon a2b plus ribavirin for 48 weeks or for 24 weeks versus interferon a2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus显示文摘 | Poynard T Mareellln P Lee SS Minuk GS Ideo G Bain V Heathcote J Zeuzem S Trepo C Albrecht J | | 0，，： | 1 |
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