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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Stimulation of lilium pollen germination by pyrroloquinoline quinone显示文摘 | Long B X Jiro S Noboru S | 1988 | Agric Biol Chem1988，52，4： | 2 |
| 3 | Synthesis and bioactivity of novel 3-(1-hydroxyethylidene)-5-substituted-pyrrolidine-2,4-dione derivatives显示文摘3-(1-hydroxyethylidene ) 的十新奇 5 代用品衍生物 pyrrolidine-2,4-dione 被综合。混合物被红外, 1H NMR, MS 和元素的分析证实。生物鉴定分别地显示这些混合物显示出显著 herbicidal 活动,并且混合物 6f 和 6j 对 Echinochloa crusgalli 的梗展出了优秀禁止的活动,与 94.4 和 72.7 mg/L 的 EC50 价值。 | B ao Feng Han Qing Ming Shi Xian Feng Wang Jian Bo Liu Sheng Qiang Chun Long Yang | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 4 | Positive Feedback Investment Strategies and Destabilizing Rational Speculation显示文摘 | DE LONG J B SHLEIFER A SUMMERS L H | 1990 | Journal of Finance1990，45，6： | 1 |
| 5 | Functicnal recovery of nencemented total hip arthroplasty显示文摘 | Long WT Dorr LD Healy B | 1993 | Clin Orthop1993，288，1： | 1 |
| 6 | Fabrication and Characterization of Single Electron Transistor on SOI显示文摘 | Wang Q Chen Y F Long S B | 2007 | Microelectronic Engineering2007，84，58： | 1 |
| 7 | Erbium: YAG laser-assisted cataract surgery 显示文摘 | Stevens GJr Long B Hamann JM | 1998 | Ophthalmic Surg Lasers1998，29，： | 1 |
| 8 | Facts & figures chemical R & D显示文摘 | Brennan M B Long J R Zurer P R | 1997 | C & EN1997，75，35： | 1 |
| 9 | Delayed presentation of an enterocutaneous fistula after tension-free vaginal tape sling 显示文摘 | Westermann L B Brown A Long J B | 2011 | Female Pelvic Mcd Reconstr Surg2011，17，5： | 1 |
| 10 | Robotic-assisted sacrocol- popexy: technique and learning curve显示文摘 | Akl M N Long J B Giles D L | 2009 | Surgical Endoscopy2009，23，10： | 1 |
| 11 | Isolation and characterization endophytic bacteria from Sedum alfredii Hance and their potential to promote phytoextraction of zinc polluted soil 显示文摘 | LONG X X CHEN X M CHEN Y G WONG J W WEI Z B WU Q T | 2010 | World Journal Microbiology Biotechnology2010，27，： | 1 |
| 12 | A dynamic disk spin down technique for mobile computing显示文摘 | David P Helmbold E Long D D Sherrod B | 1996 | Computing and Net- working1996，，： | 1 |
| 13 | Determination of multi- residue for malachite green, gentian violet and their metabolites in aquatic products by high-performance liquid chromatography cou- pled with molecularly imprinted solid-phase extraction 显示文摘 | LONG CY MAI Z B YANG Y F | 2009 | Jour- nal of Chromatography A2009，1216，： | 1 |
| 14 | Television Based Bistatic Radar显示文摘 | Grifith H D Long B A | 1986 | lEE Proceedings1986，133，7： | 1 |
| 15 | Recent advances in solarcells based on one-dimensional nanostructure arrays 显示文摘 | YU M LONG Y Z SUN B | 2012 | Nanoscale2012，4，9： | 1 |
| 16 | Automatic plaque characterization employing quantitative and muhicontrast MRI显示文摘 | Sun B Giddens DP Long R Jr | 2008 | Magn Reson Med2008，59，1： | 1 |
| 17 | The changing face of community supported agriculture显示文摘 | LONG K B | 2010 | Culture and agriculture2010，32，1： | 1 |
| 18 | Radiation characteristics of thin-wire ternary fractal trees 显示文摘 | Werner D H Rubio B A Long B R | 1996 | Electronics Letters1996，35，8： | 1 |
| 19 | Endoscopy assisted percutaneous anterior interbody fusion with subcutaneous suprafascial internal fixation: evolution of technique and surgical considerations 显示文摘 | Mathews H H Long B H | 1995 | Orthop Int ED1995，3，： | 1 |
| 20 | Purchasing: a competitive weapon显示文摘 | Long B G | 1988 | Journal of Purchasing and Materials Management1988，24，3： | 1 |
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