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| 1 | Ⅰ型干扰素诱导的内在代谢改变是其免疫功能的关键显示文摘随着对Ⅰ型干扰素诱导的复杂宿主反应越来越深刻地了解,科学家们在一些细胞因子相关的疾病治疗方案的研发上取得了新进展。本研究发现,在TLR-9受体激动剂CpGA的刺激下,通过自分泌Ⅰ型干扰素的受体依赖途径,浆细胞样树突状细胞(pDC)可产生Ⅰ型干扰素,后者可诱导细胞代谢发生变化,包括细胞的脂肪酸氧化(FAO)和氧化磷酸化(OXPHOS)水平增加。直接抑制脂肪酸氧化及其相关过程,如脂肪酸合成,可抑制pDC的完全激活。Ⅰ型干扰素也能促进非造血细胞和病毒感染的细胞FAO和OXPHOS的升高。PPARα参与了Ⅰ型干扰素诱导的代谢变化过程。我们的研究提示了FAO、OXPHOS、PPARα可作为潜在的Ⅰ型干扰素效应的下游干预靶点。 | 武多娇 Sanin DE Everts B 卓乐盈 | 2016 | 中国临床医学2016，23，4： | 13 |
| 2 | Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth显示文摘Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing,China.Methods The study design was one-year cluster randomized controlled trial of physical activity intervention(20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline.Results After the one-year intervention,BMI increased by 0.56 kg/m^2(SD 1.15) in the intervention group and by 0.72 kg/m^2(SD 1.20) in the control group,with a mean difference of-0.15 kg/m^2(95%CI:-0.28 to-0.02).BMI z score decreased by-0.05(SD 0.44) in the intervention group,but increased by 0.01(SD 0.46) in the control group,with a mean difference of-0.07(-0.13 to-0.01).After another year of follow up,compared to the control group,children in the intervention group had significantly lower BMI(-0.13,-0.25 to-0.01),BMI z score(-0.05,-0.10 to-0.01),fat mass(-0.27 kg,-0.53 to-0.02) and percent body fat(-0.53,-1.00 to-0.05).The intervention had a more pronounced effect on weight,height,BMI,BMI z score,and body composition among obese children than among normal weight or overweight children.Compared to the control group,the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1(P=0.008) and year 2(P=0.04).Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight,BMI,and body fatness in primary school students. | YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 5 |
| 3 | Electron microscope investigation of sieve element ontogeny and structure in Ulmus americana显示文摘 | EVERT R F DESHPANDE B P | 1969 | Protoplasma1969，68，： | 1 |
| 4 | Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses 显示文摘 | Everts B Smits HH Hokke CH | 2010 | Eur J Immunol2010，40，6： | 1 |
| 5 | Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types Ⅰ and Ⅱ in hyper- and hypothyroid rats 显示文摘 | Van der Heide SM Joosten B J Everts ME | 2004 | J Endocrinol2004，18，3： | 1 |
| 6 | Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status显示文摘 | Seyfried J Evert B Schwarz CS | 2003 | Free Radic Biol Med2003，34，12： | 1 |
| 7 | Omega-1, a glycoproteinsecreted by Schistosoma mansoni eggs, drives Th2 responses 显示文摘 | Everts B Perona-Wright G Smits HH | 2009 | JExp Med2009，206，8： | 1 |
| 8 | Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization显示文摘 | van Riet E Everts B Retra K | 2009 | BMC Immunol2009，10，： | 1 |
| 9 | Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses显示文摘 | Everts B Wright GP Smits HH | 2009 | J Exp Med2009，206，8： | 1 |
| 10 | Firm Size, In- dustry Mix and the Regional Transmission of Monetary Policy in Germany显示文摘 | Ivo J M Arnold Evert B Vrugt | 2002 | German Economic Review2002，，5： | 1 |
| 11 | COX-2 Special inhibitors the emergence of new class of analgesic and anti-inflammatory drugs 显示文摘 | Everts B Wahrbrog P Hedner T | 2000 | Clin Rheumatol2000，19，： | 1 |
| 12 | Mitochondrial DNA in aging degenerative disease显示文摘 | BERDANIER C D EVERTS H B | 2001 | Mutation Research2001，475，2： | 1 |
| 13 | The early clinical history of salicylates in rheumatology and pain显示文摘 | Hedner T Everts B | 1998 | Clin Rheumatol1998，17，1： | 1 |
| 14 | Overexpression of Bcl-2 results in reduction of cytocbrome c content and inhibition of complex I activity显示文摘 | Schwarz C S Evert B O Seyfried J | 2001 | Biochem Biophys Res Commun2001，280，4： | 1 |
| 15 | Interactions underlying assembly of the Escherichia coli AcrAB - TolC multidrug efflux system显示文摘 | Thierry T Jeyanthy E Evert B | 2004 | Mol Microbiol2004，53，2： | 1 |
| 16 | Overexpression of bcl-2 results in reduction of cytochrome c content and inhibition of complex I activity显示文摘 | SCHWARZ C S EVERT B O SEYFRIED J | 2001 | Biochem Biophys Res Commun2001，280，4： | 1 |
| 17 | Comparison of saturated hydraulic conductivity measurement methods for a glacial fill soil显示文摘 | Mohanty B P Kanwar R S Everts C J | 1994 | Soil Science Society of America Journal1994，58，： | 1 |
| 18 | US structure fires in eating and drinking establishments显示文摘 | EVERTS B | 2011 | National Fire Protection Association Journal2011，105，1： | 1 |
| 19 | Impairments of brain and behavior: the neurological effects of alcohol显示文摘 | Oscar - Berman M Shagrin B Evert DL | 1997 | Alcohol Health and Research World1997，21，1： | 1 |
| 20 | Evidence-based Dia- betes Nutrition Therapy Recommendations are Effective: The Key is Individualization显示文摘 | Franz M J Boucher J L Evert A B | 2014 | Diabetes Metah Syndr Obes2014，，7： | 1 |
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