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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | A hybrid elastic model allowing real time cutting, deformations and force-feedback for surgery training and simulation 显示文摘 | S Cotin H Delingette N Ayache | 2000 | Visual Computer journal (S0178-2789)2000，16，8： | 1 |
| 3 | Removing tetrahedra from manifold tetrahedralisation: application to real-time surgical simulation 显示文摘 | C Forest H Delingette N Ayache | 2005 | Medical Image Analysis (S1361-8415)2005，，9： | 1 |
| 4 | A Riemannian framework for tensor computing 显示文摘 | PENNEC X FILLARD P AYACHE N | 2006 | International Journal of Computer Vision2006，66，1： | 1 |
| 5 | A hybrid elastic model allowing real-time cutting, deformations and force-feedback for surgery training and simulation显示文摘 | COTIN S DELINGETTE H AYACHE N | 2000 | The Visual Computer2000，16，8： | 1 |
| 6 | Non-linear Anisolxopic Elasticity for Real-time Surgery Simulation显示文摘 | Picinbono G Delingette H Ayache N | 2003 | Graphical Models2003，65，5： | 1 |
| 7 | Optical characterization of β-FeSiz layers formed by ion beam synthesis 显示文摘 | Ayache R Bouabellou A Richter E | 2004 | Materials Science in Semiconductor Processing2004，7，46： | 1 |
| 8 | A hybrid elastic model allowing real-time cutting, deformations and force-feedback for surgery training and simulation 显示文摘 | Cotin S I)elingette H Ayache N | 2000 | Visual Computer Journal2000，16，8： | 1 |
| 9 | 3D-2D projective registration of free-form curves and surfaces显示文摘 | FELDMAR J AYACHE N BETTING F | 1997 | Comput Vis Image Underst1997，65，3： | 1 |
| 10 | Adipose graft:an original option in myringoplasty 显示文摘 | Ayache S Braccini F Facon F | 2003 | Otol Neuroto12003，24，： | 1 |
| 11 | A hybrid elastic model allowing real time cutting,deformations and force-feedback for surgery training and simulation显示文摘 | S Cotin H Delingette N Ayache | 2000 | Visual Computer journal2000，16，8： | 1 |
| 12 | Fistula of the fourth branchial pouch:apropos of acase treated by endoscopic cauterization显示文摘 | AYACHE D TECHUENTE A N COHEN M etal | 2001 | Rev Lar-yngol Otol Rhinol(Bord)2001，122，： | 1 |
| 13 | A riemannian framework for tensor computing显示文摘 | PENNEC X FILLARD P AYACHE N | 2006 | International Journal of Computer Vision2006，66，1： | 1 |
| 14 | The practical challenges of interference alignment显示文摘 | El Ayach 0 Peters S W Heath R WJr | 2013 | IEEE Wireless Communications2013，20，1： | 1 |
| 15 | Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction 显示文摘 | Ayach BB Yoshimitsu M Dawood F | 2006 | Proc Natl Acad Sci USA2006，103，7： | 1 |
| 16 | A hybrid elastic modelallowing real-time cutting,deformations and force-feedback for surgery training and simulation显示文摘 | Cotin S Delingette H Ayache N | 2000 | VisualComuputer J2000，16，8： | 1 |
| 17 | Real-time elastic deformations of soft tissues for surgery simulation显示文摘 | Cotin S Delingette H Ayache N | 1999 | IEEE Transactionson Visualization and Computer Graphics1999，5，1： | 1 |
| 18 | A Riemannian framework for tensor computing显示文摘 | Pennec X Fillard P Ayache N | 2006 | International Journal of Computer Vision2006，66，1： | 1 |
| 19 | Comparision of laryngoscopy and CT-scan results before partial laryngectomy 显示文摘 | AYACHE S STRAMANDINOLI E TRAMIER B | 2003 | Ann Otolaryngol Chir Cervicofac2003，120，5： | 1 |
| 20 | Frequency-based non-rigid motion analysis显示文摘 | Nastar C Ayache N | 1996 | IEEE Trans PAMI1996，18，11： | 1 |
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