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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | On egg fractionation: applications of liquid chromatography to the isolation and the purification of hen egg white and egg yolk proteins显示文摘 | AWADE A C | 1996 | Zeitschrift fUr Lebensmitteluntersuchung und Forschung A1996，202，1： | 1 |
| 3 | Effect of β-sitosterol, a plant sterol, on growth, protein phosphatase 2A and phospholipida D in LNCaP cells显示文摘 | Awad A B Gan Y Fink C S | 2000 | Nutr Cancer2000，36，： | 1 |
| 4 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of interactive marketing2007，21，4： | 1 |
| 5 | The relationship between impaired glucose tolerance,type 2 diabetes,and congnitive function显示文摘 | Awad N Gagnon M Messier C | 2004 | J Clin Exp Neuropsychol2004，26，8： | 1 |
| 6 | The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive funetion显示文摘 | Awad N Gagnon M Messier C | 2004 | J Clin Exp Neuropsychol2004，26，8： | 1 |
| 7 | Beta-sitosterol, a plant sterol, in-duces apoptosis and activates key ~'aspases in MDA-blB-231 hu-man breast cancer cells显示文摘 | Awad A B Roy R Fink C S | 2003 | Oncol Rep2003，10，： | 1 |
| 8 | -sitosterol activates fas signaling in human breast cancer cells显示文摘 | Awad A B Chinnam M Fink C S | 2007 | Phytomedicine2007，14，： | 1 |
| 9 | Exploring the value of online product reviews' in forecasting sales: The case of motion pictures 显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 10 | Exploring the Value of On- line Product Reviews in Forecasting Sales : The Case of Motion Pic- tures 显示文摘 | Dellarocas C Zhang X Q Awad N F | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 11 | Phosphorus enhancement of salt tolerance of tomato显示文摘 | Awad A S Edwards D G Campbel L C | 1990 | Corp Science1990，30，： | 1 |
| 12 | Comparison of three liquid chromatography method for egg-white protein analysis显示文摘 | AWADE A C EFSTATHIOU T | 1999 | Journal of Chromatography B1999，723，： | 1 |
| 13 | Deposition of duplex Al2O3/TiN coating on aluminum alloys for tribological applications using a combined micro-plasma oxidation (MPO) and arc ion plating (AIP)显示文摘 | Awad S H Qian H C | 2006 | Wear2006，260，： | 1 |
| 14 | The relationship between im- i~aired glucose tolerance, type 2 diabetes and cognitiive function 显示文摘 | Awad N Gagnon M Messier C | 2004 | J Clin Exp Neuropsyehol2004，26，11： | 1 |
| 15 | Recessive arrhythmogenic fight ventricular dysplasia due to novel cryptic splice mutation in PKP2显示文摘 | Awad MM Dalai D Tichnell C et ai | 2006 | Hum Mutat2006，27，11： | 1 |
| 16 | Two-step chromatography procedure for the purification of hen egg white ovomucin, lysozyme, ovotransferrin and ovalbumin and characterization of purified proteins显示文摘 | AWADE A C MOREAU S MOLLE D | 1994 | Journal of chromatography A1994，677，2： | 1 |
| 17 | Exploring the value of on- line product reviews in forecasting sales: The case of motion pictures 显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of Interactive marketing2007，21，4： | 1 |
| 18 | Isolation of hen egg white lysozyme, ovotransferrin and ovalbumin, using a quaternary ammonium bound to highly crosslinked agarose matrix显示文摘 | VACHIER M C PIOT M AWADE A C | 1995 | Journal of Chromatography B1995，664，： | 1 |
| 19 | Structural bone allograft cornbined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering 显示文摘 | Xie C Reynolds D Awad H | 2007 | Tissue Eng2007，13，3： | 1 |
| 20 | Comparison of three liquid chromatographic methods for egg-white protein analysis显示文摘 | AWADE A C EFSTATHIOU T | 1999 | Journal of Chromatography1999，723，12： | 1 |
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