|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 拉米夫定/干扰素-α联合治疗围生期感染乙肝的免疫耐受患儿:一项初步研究显示文摘Objective:To investigate whether combining the antiviral effect of lamivudine with the immune-boosting action of interferon-alpha(IFN-α)is effective in treating hepatitis B virus(HBV)“immunotolerant”children.Study design:Twen tythree children(8 boys;mean age,10 years)infected during the first year of life(17 Asian,21 with normal aminotransferase levels,15 with HBV-DNA > 1000 pg/mL by hybridization and all with mild histologic changes)were treated with l amivudine(3 mg/kg)for 8 weeks alone and then lamivudine(3 mg/kg)-and IFN-α(5 MU/m2,3 times weekly)in combination for 10 months.Results:Seventy-eight percent became HBV-DNA negative at the end of treatment,5(22%)seroconverted to anti-HBe,4(17%)of whom achieved complete viral control,becoming persis tently HBsAg negative and anti-HBs positive.None had YMDD mutations.The viral status of the patients has not changed after a median follow-up of 40 months(range,36 to 48).Conclusions:This pilot study suggests that lamivudine pretrea tment followed by a combination of lamivudine and IFN-αcan induce complete vir al control in HBV immunotolerant children,hitherto considered poor responders. | D'Antiga L. Aw M. Atkins M. G.Mieli-Vergani 王一飞 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 4 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | NOS- 2 mediates the protective anti - inflammatory and antifibrotic effects of the Th1 - inducing adjuvant,IL- 12,in a Th2 model of granulomatous disease显示文摘 | Cheever AW Jankovic D | 2000 | Am J Pathol2000，157，3： | 1 |
| 4 | The molecular physiology of liver regeneration following partial hepatectomy显示文摘 | Mangnall D Bird D Majeed AW ct al | 2003 | Liver International2003，23，2： | 1 |
| 5 | Peripheral artevial disease in the elderly; the Rtterdam Study显示文摘 | Meijer WT Hoes AW Rutgers D | 1998 | Arterioscler Throm Vase Biol1998，18，： | 1 |
| 6 | Flav onoid andchlorogenic acid levels inapple fruit: char acterisation of variation显示文摘 | AW AD M A JAGER A D van WESTING L M | 2000 | Scientia Horticulturae2000，83，34： | 1 |
| 7 | The molecular physiology of liver regeneration following partial hepatectomy显示文摘 | Mangnall D Bird NC Majeed AW | 2003 | Liver Int2003，23，2： | 1 |
| 8 | Expression of the target receptor CD33 in CD34^ +/CD38^ -/CD123 ^+ AML stem cells显示文摘 | Hauswirth AW Florian S Printz D | 2007 | Eur J Clin Invest2007，37，1： | 1 |
| 9 | Effects of percutaneous coronary interventions in silent ischemia after myocardial infarction: the SWISSI II randomized controlled trial显示文摘 | Erne P Schoenenberger AW Burckhardt D | 2007 | JAMA2007，297，： | 1 |
| 10 | An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection显示文摘 | Wynn TA Cheever AW Jankovic D | 1995 | Nature1995，376，6541： | 1 |
| 11 | Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-a-drenal axis显示文摘 | D Zhou AW Kusnecov MR Shurin | 1992 | Endocrinology1992，133，6： | 1 |
| 12 | Immune thrombocytopenia complicating pulmonary tuberculosis:case report and investigation of mechanisms显示文摘 | Boots RJ Roberts AW McEvoy D | 1992 | Thorax1992，47，5： | 1 |
| 13 | CD4+ T cell- mediated granulomatous pathology in schistosomiasis is down- regulated by a B cell-dependent mechanism requiring Fc receptor signaling显示文摘 | Jankovic D Cheever AW Kullberg MC | 1998 | J Exp Med1998，187，4： | 1 |
| 14 | Phase-contrast radiography显示文摘 | Pogany A Stevenson AW | 1998 | Imaging & Therapeutic Technology1998，18，5： | 1 |
| 15 | Cancer antigen 125 in pa- tients with chronic liver disease显示文摘 | Devarbhavi H Kaese D Williams AW | 2002 | Mayo Clin Proc2002，77，6： | 1 |
| 16 | Omega-3 fatty acid supple- mentation in patients with chronic epilepsy:a randomized triM显示文摘 | Yuen AW Sander JW Fluegel D | 2005 | Epilepsy Behav2005，7，2： | 1 |
| 17 | Autoimmune hepatitis-Up- date 2015 显示文摘 | Marms MP Lohse AW Verganl D | 2015 | J Hepato12015，62，1： | 1 |
| 18 | Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery 显示文摘 | Wallace AW Galindez D Salahieh A | 2004 | Anesthesiology2004，101，2： | 1 |
| 19 | The molecular physiology of liver regeneration following partial hepatectomy 显示文摘 | Mangnall D Bird NC Majeed AW | 2003 | Liver Int2003，23，2： | 1 |
| 20 | Quantitative methods in phase-contrast X-ray imaging 显示文摘 | Gureyev TE Stevenson AW Paganin D | 2000 | J Digit Imaging2000，13，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员