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| 1 | Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG显示文摘Dendritic-cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN;CD209)has an important role in mediating adherence of Mycobacteria species,including M.tuberculosis and M.bovis BCG to human dendritic cells and macrophages,in which these bacteria can survive intracellularly.DC-SIGN is a C-type lectin,and interactions with mycobacterial cells are believed to occur via mannosylated structures on the mycobacterial surface.Recent studies suggest more varied modes of binding to multiple mycobacterial ligands.Here we identify,by affinity chromatography and mass-spectrometry,four novel ligands of M.bovis BCG that bind to DC-SIGN.The novel ligands are chaperone protein DnaK,60 kDa chaperonin-1(Cpn60.1),glyceraldehyde-3 phosphate dehydrogenase(GAPDH)and lipoprotein lprG.Other published work strongly suggests that these are on the cell surface.Of these ligands,lprG appears to bind DC-SIGN via typical proteinglycan interactions,but DnaK and Cpn60.1 binding do not show evidence of carbohydrate-dependent interactions.LprG was also identified as a ligand for DC-SIGNR(L-SIGN;CD299)and the M.tuberculosis orthologue of lprG has been found previously to interact with human toll-like receptor 2.Collectively,these findings offer new targets for combating mycobacterial adhesion and within-host survival,and reinforce the role of DCSIGN as an important host ligand in mycobacterial infection. | Maria V.Carroll Robert B.Sim Fabiana Bigi Anne Jäkel Robin Antrobus Daniel A.Mitchell | 2010 | Protein & Cell2010，1，9： | 7 |
| 2 | Bolus or slow titrated injection of midazolam prior to upper gastrointestinal endoscopy? Relative effect on oxygen saturation and prophylactic value of supplemental oxygen 显示文摘 | Bell GD Antrobus JH Lee J | 1990 | Aliment Pharmacol Ther1990，4，： | 1 |
| 3 | Novel serum biomarker candidates for liver fibrosis in hepatitis C patients显示文摘 | Gangadharan B Antrobus R Dwek R | 2007 | Clin Chem2007，53，10： | 1 |
| 4 | Coadministration of seasonal influenza vaccine and MVA-NP-M1 simultaneously achieves potent humoral and cell-mediated re- sponses显示文摘 | ANTROBUS RD BERTHOUD TK MULLARKEY CE | 2014 | Mol Ther2014，22，1： | 1 |
| 5 | Identification of early molecular pathways affected by paraquat in rat lung显示文摘 | MAINWARING G LING LIM F ANTROBUS K | 2006 | Toxicology2006，225，： | 1 |
| 6 | Identifieation of early molec- ular pathways affeeted by paraquat in rat lung显示文摘 | Mainwaring C Lim F Antrobus K | 2006 | Toxieology2006，225，23： | 1 |
| 7 | Role for the obesi- ty-related FTO gene in the cellular sensing of amino acids 显示文摘 | Gulati P Cheung M K Antrobus R | 2013 | Proc Natl Acad Sci U S A2013，110，7： | 1 |
| 8 | Role for the obesity-related FTO gene in the cellular sensing of amino acids显示文摘 | Gulati P1 Cheung MK Antrobus R | 2013 | Proc Nail Acad Sci2013，110，7： | 1 |
| 9 | Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum显示文摘 | Pardo M Garcia A Antrobus R | 2007 | J Proteome Res2007，6，7： | 1 |
| 10 | A rapid flow eytometric assay to detect CD4^+ and CD8^+ T helper(Th) O, Th1 and Th2 cells in whole blood and its application to study cytokine levels in atopic dermatitis before and after cyclosporine therapy 显示文摘 | FARRELL A M ANTROBUS P SIMPSON D | 2001 | British J Derm2001，144，1： | 1 |
| 11 | Novel serum biomarker candidates for liver fibrosis in hepatitis C patients 显示文摘 | GANGADHARAN B ANTROBUS R RAYMOND A | 2007 | Clinical Chemistry2007，53，10： | 1 |
| 12 | Identificationof early molecular pathways affected by paraquat in ratlung显示文摘 | Mainwaring G Lim FL Antrobus K | 2006 | Toxicology2006，225，23： | 1 |
| 13 | Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation 显示文摘 | Fielding CA Aicheler R Stanton RJ Wang EC Han S Seirafian S Davies J McSharry BP Weekes MP Antrobus PR Prod' homme V Blanchet FP Sugrue D Cuff S Roberts D Davison AJ Lehner PJ Wilkinson GW Tomasec P | 2014 | PLoS Pathog2014，10，10： | 1 |
| 14 | Mind-wandering and cognitive structure显示文摘 | ANTROBUS J S SINGER J L GOLDSTEIN S | 1970 | Transactions of the New York Academy of Sciences1970，32，2： | 1 |
| 15 | HCMV pULl35 remodels the actin cytoskeleton to impair immune recognition of infected cells 显示文摘 | Stanton RJ Prod' homme V Purbhoo MA Moore M Aicheler RJ Heinzmann M Bailer SM Haas J Antrobus R Weekes MP Lehner PJ Vojtesek B Miners KL Man S Wilkie GS Davison AJ Wang EC Tomasec p Wilkinson GW | 2014 | Cell Host Microbe2014，16，2： | 1 |
| 16 | New approaches for biomarker discovery: the search for liver fibrosis markers in hepati- tis C patients 显示文摘 | Gangadharan B Antrobus R Chittenden D | 2011 | J Proteome Res2011，10，5： | 1 |
| 17 | Bolus or slow titrated injection of midazolam prior to upper gastrointestinal endoscopy? Relative effect on oxygen saturation and prophylactic value of supplemental oxygen显示文摘 | Antrobus JH Lee | 1990 | Aliment Pharmacol Ther1990，4，： | 1 |
| 18 | Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: Regulating adaptation to citric acid stress显示文摘 | Lawrence C L Botting C H Antrobus R | 2004 | Molecular and Cellular Biology2004，24，8： | 1 |
| 19 | Information theory and stimulus-independent thought 显示文摘 | Antrobus JS | 1968 | Br J Psychol1968，59，： | 1 |
| 20 | Bolus or slow titrated imjection of midazolam prior to upper gastrointestinal endoscopy? Relative effect on oxygen saturation and prophylactic value of supplemental oxygen 显示文摘 | BELL G D ANTROBUS J H LEE J | 1990 | Aliment Pharmacol Ther1990，4，： | 1 |
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