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| 1 | Hepatocellular carcinoma treated with transarterial chemoembolization: Dynamic perfusion-CT in the assessment of residual tumor显示文摘AIM: To asses the value of computed tomography (CT)-perfusion in the detection of residual hepatocellular carcinoma (HCC) vascularization after transarterial chemoembolization (TACE). METHODS: Thirty-two consecutive patients were pro-spectively included in this study. All patients had liver cirrhosis and a conf irmed HCC lesion which was treated with TACE. One month after treatment, perfusion measurements of treated lesions were carried out. The CTperfusion (CT-p) protocol was performed with 16 slice multidetector computed tomography which included the following parameters: 8 dynamic slices/scan per 40 scans after iv injection of 50 mL of iodinated contrast (350 mg/mL) at a flow rate of 6 mL/s. Treated lesions were evaluated using dedicated perfusion software, which generated a quantitative colour map of perfusion. The following parameters were considered: hepatic perfusion (HP), arterial perfusion (AP), blood volume (BV), hepatic perfusion index (HPI), and time to peak (TTP). Perfusion parameters were described with quartile values of their distribution and statistically analyzed. RESULTS: Perfusion parameters of the treated lesions could be quantitatively assessed using CT-p analysis. The presence of residual tumor tissue was observed in 13 of the 32 patients. The values of the perfusion parameters measured within the relapse tissue were: HP (mL/100 g per minute): median = 44.4 (1stqt = 31.3, 3rdqt = 55.8); BV (mL/100 g): median = 18.7 (1stqt = 11.5, 3rdqt = 22.5); AP (mL/min): median = 39.0 (1stqt = 36.5, 3rdqt = 61.3); HPI (%): median = 34.0 (1stqt = 30.4, 3rdqt = 38.9); TTP (s): median = 17.3 (1stqt = 15.8, 3rdqt = 26.5). With the use of the univariate paired Wilcoxon signed rank test, HP, AP and HPI were shown to be significantly higher (P<0.001) in the relapse site than in the primary lesion. The BV and TTP parameters showed a tendency to be greater and lower, respectively, in the relapse site than in the primary lesion. CONCLUSION: In patients with HCC treated with TACE, CT-p provides measurement of flow parameters related to residual arterial structures in viable tumor, thus helping in the assessment of therapeutic response. | Davide Ippolito Pietro Andrea Bonaff ini Laura Ratti Laura Antolini Rocco Corso Ferruccio Fazio Sandro Sironi | 2010 | World Journal of Gastroenterology2010，16，47： | 15 |
| 2 | Multiphoton muhifocal microscopy exploiting a diffractive optical element 显示文摘 | SACCONI L FRONTER E ANTOLINI R | 2003 | OptLett2003，28，20： | 1 |
| 3 | Sintering high temperature strength and oxidation resistance of liquid-phase-pressureless-sintered SiC-A1N ceramics with addition of rare-earth oxides 显示文摘 | Giuseppe Magnani Francesco Antolini Leandro Beaulardi | 2009 | Journal of the European Ceramic Society2009，29，11： | 1 |
| 4 | Hypertension, pre- hypertension,and transient elevated blood pressure in chil- dren:association with weight excess and waist circumference 显示文摘 | Genovesi S Antolini L Giussani M | 2010 | Am J Hypertens2010，23，1： | 1 |
| 5 | LiCoO2: oxygen nonstoichiometry, Formation, structure, lithium and electrochemical behavior and transport properties显示文摘 | ANTOLINI E | 2004 | Solid State Ionics2004，170，34： | 1 |
| 6 | The methanol oxidation reaedon on platinum alloys with the first row transition metals:The case of Pt-Co and-Ni alloy eleetroeatalysts for DMFCs:A short review显示文摘 | Antolini E Salgodo J R C Gonzalez E R | 2006 | Applied Catalysis B:Environmental2006，63，： | 1 |
| 7 | LiCoO2: formation, structure, lithium and oxygen nonstoichiometry, electrochemical behaviour and transport properties显示文摘 | ANTOLINI E | 2004 | Solid State Ionics2004，170，： | 1 |
| 8 | Influence of Nation loading in catalyst layer of gas-diffusion electrodes for PEFC 显示文摘 | ANTOLINI E GIORGI L POZIO A | 1999 | Power Sources1999，77，2： | 1 |
| 9 | LiCoO2 : formation, structure, lithium and oxygen nonstoichiometry, electrochemical behaviour and transport properties显示文摘 | Antolini E | 2004 | Solid State Ionics2004，170，34： | 1 |
| 10 | Formation of carbon-supported PtM alloys for low temperature fuel cells:A review显示文摘 | ANTOLINIE | 2003 | Materials chemistry and physics2003，78，： | 1 |
| 11 | Serum uric acid and blood pressure in children at cardiovascular risk 显示文摘 | Viazzi F Antolini L Giussani M | 2013 | Pediatrics2013，132，1： | 1 |
| 12 | Pt-Co/C electrocatalysts for oxygen reduction in H2/O2 PEMFCs synthesized by borohydride method显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Electrochem Soc2004，151，12： | 1 |
| 13 | Carbon supports for low-temperature fuel cell catalysts显示文摘 | Ermete Antolini | 2009 | Applied Catalysis B :Environmental2009，88，： | 1 |
| 14 | Structure and activity of carbon-supported Pt-Co electrocatalysts for oxygen reduction显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Phys Chem B2004，108，17： | 1 |
| 15 | Carbon nanotubes as SAW chemical sensors materials显示文摘 | Penza M Antolini F Antisari M Vittori | 2004 | Sensors and Actuators B:Chemical2004，100，12： | 1 |
| 16 | Carbon supported Pt70Co30 electrocatalyst prepared by the formic acid method for the oxygen reduction reaction in polymer electrolyte fuel cells显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2005 | J Power Sources2005，141，1： | 1 |
| 17 | Characterisation of Emilia-Romagna region in relation with late frost risk显示文摘 | Zinoni F Antolini G Campisi T | 2002 | Physics and Chemistry of the Earth2002，，27： | 1 |
| 18 | Formation of carbon supported PtRu alloys:an XRD analysis 显示文摘 | Antolini E Cardellini F | 2001 | J Alloys Comp2001，315，12： | 1 |
| 19 | Visualization of the local catalytic activity of electrodeposited Pt-A4g catalysts for oxygen reduction by means of SECM显示文摘 | Antolini E | 2007 | Appl Catal B2007，，74： | 1 |
| 20 | 显示文摘 | | 2003 | Materials Chemistry and Physics2003，78，3： | 1 |
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