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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | The LMDI approach to decomposition analysis: a practical guide显示文摘 | ANG B W | 2005 | Energy Policy2005，33，： | 1 |
| 3 | Handling zero values in the logarithmic mean divisia index decomposition approach 显示文摘 | Ang B W Na Liu | 2007 | Energy Policy2007，，35： | 1 |
| 4 | Total factor carbon e-mission performance; a malmquist index analysis显示文摘 | ZHOU P ANG B W HAN J Y | 2010 | En-ergy Economics2010，32，1： | 1 |
| 5 | Total factor carbon emission performance: a malmquist index analysis显示文摘 | Zhou P Ang B W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 6 | Decomposition analysis for policymaking in energy:which is the preferred method?显示文摘 | ANG B W | 2004 | Energy Policy2004，32，9： | 1 |
| 7 | Handling zero values in the logarithmic mean divisia index decomposition approach显示文摘 | ANG B W Liu N | 2007 | Energy Policy2007，35，1： | 1 |
| 8 | Measuring environmental per- formance under different environmental DEA technologies 显示文摘 | ZHOU P ANG B W POH K L | 2008 | En- ergy Economics2008，30，1： | 1 |
| 9 | Decomposition of Aggregate Energy and Gas Emission Intensities for Industry:a Refined Divisia Index Method显示文摘 | Ang B W K H Choi | 1997 | The Energy Journal1997，18，3： | 1 |
| 10 | CO2 Emissions, Energy Consumption, and Output in France 显示文摘 | ANG J B | 2007 | Energy Policy2007，，35： | 1 |
| 11 | Total Factor Carbon Emission Per-formance :A Malmquist Index Analysis 显示文摘 | Zhou P Ang B W Han J Y | 2010 | Enei^y Economics2010，32，1： | 1 |
| 12 | A survey of data envelop-ment analysis in energy and environmental studies显示文摘 | ZHOU P ANG B W POH K L | 2008 | Euro-pean Journal of Operational Research2008，189，1： | 1 |
| 13 | A survey of index decomposition analysis in energy and environmenal studies 显示文摘 | ANG B W ZHANG F Q | 2000 | Energy2000，25，12： | 1 |
| 14 | Factorizing Changes in Energy and Environmental Indicators Through Decomposition 显示文摘 | ANG B W ZHANG F Q CHOI K H | 1998 | En- ergy1998，23，6： | 1 |
| 15 | Mutagenic and genotoxic effects of the atrazine herbicide in Oreochromis niloticus(Perciformes,Cichlidae)detected by the micronuclei test and the comet assay显示文摘 | Ventura B C de Angelis D F Marin-Morales M A | 2008 | Pestic Biochem Physiol2008，90，1： | 1 |
| 16 | Decomposition analysis for policy making in energy: which is the preferred method? 显示文摘 | Ang B W | 2004 | Energy Policy2004，32，9： | 1 |
| 17 | Determination of lincomycin residues in salmon tissues by gas chromatography with nitrogen- phosphorus detection显示文摘 | Luo W Yin B Ang C Y W | 1996 | J Chromatography B Biomed Appl1996，687，2： | 1 |
| 18 | Factorizing changes in energy and environmental indicators through decompo- sition 显示文摘 | ANG B W ZHANG F Q CHOI K H | 1998 | Energy1998，23，6： | 1 |
| 19 | Linear programming models for measuring economy-wide energy efficiency performance显示文摘 | ZHOU P ANG B W | 2008 | Energy Policy2008，，36： | 1 |
| 20 | A Study on the Fuel consumption Characteristics of Public Buses 显示文摘 | ANG B W FWA T F | 1989 | En ergy1989，14，12： | 1 |
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