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| 1 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 2 | Diversity of fungal isolates from fungus-growing termite Macrotermes barneyi and characterization of bioactive compound from Xylaria escharoidea显示文摘Owing to their potential applications,as well as their structural diversity,the discovery of novel secondary metabolites from insect-associated fungi has been of interest to researchers in recent years.The aim of this study was therefore to estimate the diversity of fungi associated with fungus-growing termites and bioprospecting these for potential secondary metabolites.In total,18 fungal species were isolated and described from the gut and comb of Macrotermes barneyi based on 18S ribosomal DNA gene sequence analysis.Antimicrobial activity assays were carried out on all the known fungi,and nine isolates were recorded as active against pathogenic fungi.Xylaria escharoidea,the best performing isolate,was grown at laboratory scale and 4,8-dihydroxy-3,4-dihydronaphthalen-l(2H)was isolated and characterized.The minimum inhibitory concentration of this isolated compound against tested pathogenic organisms was found to be 6.25 fig.In addition,molecular docking studies have revealed that 4,8-dihydroxy-3,4-dihydronaphthalen-l(2H)is a prominent antibacterial agent with a marked interaction with key residues on protein A(agrAc)that regulates the accessory gene.The findings of this study support the drug discovery of antimicrobial properties in insect-associated fungi,which may lead to novel secondary metabolites. | Venkateswarulu Nagam Rammohan Aluru Muhammad Shoaib Guang-Rui Dong Zhi Li Veera Bramhachari Pallaval Jin-Feng Ni | 2021 | Insect Science2021，28，2： | 2 |
| 3 | Simulating the behavior of MEMS devices:computational methods and needs显示文摘 | SENTURIA S D ALURU N WHITE J | 1997 | IEEE Computational Science &Engineering1997，4，1： | 1 |
| 4 | Static and dynamic analysis of carbon nanotube-based switches显示文摘 | DEQUESNES M TANG ZH ALURU N R | 2004 | Journal of Engineering Materials and Technology2004，126，： | 1 |
| 5 | A point collocation method based on reproducing kernel approximations显示文摘 | Aluru N R | 2000 | International Journal for Numerical Methods in Engineering2000，47，6： | 1 |
| 6 | Efficient mixed-domain analysis of electrostatic MEMS显示文摘 | LI G ALURU N R | 2003 | IEEE Transactions on Computer-aided Design of Integrated Circuits and Systems2003，22，9： | 1 |
| 7 | A point collocation method based on reproducing kernel approximations显示文摘 | Aluru N R | 2000 | International Journal for Numerical Methods in Engineering2000，47，6： | 1 |
| 8 | Calculation of pullin voltages for carbon-nanotube-based nanoelectromechanical switches显示文摘 | DEQUESNES M ROTKIN S ALURU N | 2002 | Nanotechnology2002，13，1： | 1 |
| 9 | Combined circuit/device modeling and simulation of integrated microfluidic systems 显示文摘 | Chatterjee A N Aluru N R | 2005 | JMEMS2005，14，1： | 1 |
| 10 | Finite cloud method:a true meshless technique base on a fixed reproducing kernel approximation显示文摘 | Aluru N R Gang L | 2001 | Int J Numer Meth Energ2001，50，4： | 1 |
| 11 | Space and time optimal parallel sequence alignments显示文摘 | Rajko S Aluru S | 2004 | IEEE Transactions on Parallel and Distributed Systems2004，18，2： | 1 |
| 12 | Transient Analysis of Electro-Osmotic Transport by a Reduced-Order Modelling Approach显示文摘 | Qiao R Aluru N R | 2003 | International Journal for Numerical Methods in Engineering2003，56，： | 1 |
| 13 | Hyperosmotic shock adaptation by cortisol involves upregulation of branchial osmotic stress transcription factor 1 gene expression in Mozambique Tilapia 显示文摘 | McGuire A Aluru N Takemura A | 2010 | General and Comparative Endocrinology2010，165，2： | 1 |
| 14 | On the equivalence between least-square and kernal approximations in meshless methods显示文摘 | Jin X Li G Aluru N R | 2001 | CMES: Computer Modeling in Engineering & Sciences2001，2，4： | 1 |
| 15 | Simulating the behavior of MEMS devices: computational methods and needs显示文摘 | SENTURIA S ALURU N WHITE J | 1997 | IEEE Computational Science and Engineering1997，4，1： | 1 |
| 16 | Meshless analysis of piezoelectric devices 显示文摘 | Ohs R R Aluru N R | 2001 | Comput Mech2001，27，： | 1 |
| 17 | Molecular characterization,tissue-specific expression,and regulation of melanocortin 2 receptor in rainbow trout显示文摘 | Aluru N Vijayan M M | 2008 | Endocrinology2008，149，9： | 1 |
| 18 | Charge Inversion and Flow reversal in a Nanochannel Electro-osmotic Flow显示文摘 | Qiao R Aluru N R | 2004 | Physical Review Letters2004，92，1983： | 1 |
| 19 | Atomistic simulations on the mechanical properties of a silicon nanofilm covered with grapheme 显示文摘 | JING Y H ALURU N R | 2011 | Computational Materials Science2011，50，10： | 1 |
| 20 | Efficient clustering of large EST data sets on parallel computers显示文摘 | Kalyanaraman A Aluru S Kothari S | 2003 | Nucleic Acids Res2003，31，11： | 1 |
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