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| 1 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 2 | Predicting arterial stiffness from the digital volume pulse waveform显示文摘 | ALTY S R NATALIA A J MILLASSEAU S C | 2007 | IEEE Transactions on Biomedical Engineering2007，54，12： | 1 |
| 3 | Development of a distributed simulator for control experiments through the Internet显示文摘 | Shuang H Yang James L Alty | 2002 | Future Generation Computer Systems2002，18，： | 1 |
| 4 | Arterial Stiffness from the Digital Volume Pulse Waveform显示文摘 | Alty S Angarita-Jaimes N Millasseau S C | 2007 | IEEE Transactions on Biomedical Engineering2007，54，12： | 1 |
| 5 | Design Issues and Implementation of Internet-based Process Control Systems显示文摘 | Yang S H Chen X Alty J L | 2003 | Control Engineering Practice2003，11，6： | 1 |
| 6 | How sensitive is investment to cash flow when financing is frictionless? 显示文摘 | Alti A | 2003 | Journal of Finance2003，58，2： | 1 |
| 7 | Impacts of Atmospheric Anthropogenie Nitrogen on the Open Ocean 显示文摘 | Duce R A La_Roche J Altied K et aI | 2008 | Science2008，320，5878： | 1 |
| 8 | Biased Beliefs, Asset Prices, and Investment: A Structural Approach显示文摘 | ALTI A TETLOCK P C | 2014 | Journal of Finance2014，69，1： | 1 |
| 9 | Multi-media Interfaces for Process Control:Matching Media to Tasks显示文摘 | Bergan M | 1995 | Control Engineering Practice1995，3，2： | 1 |
| 10 | Enhanced myeloid spe- cificity of CDl17 compared with CD13 and CD33 显示文摘 | Nomdedeu JF Mateu R Altis A | 1999 | Leuk Res1999，23，4： | 1 |
| 11 | Arterial stiffness from the digital volume pulse waveform显示文摘 | Alty S Angarita-Jaimes N Millasseau S C et at | 2007 | IEEE Transactions on Biomedical Engineering2007，54，12： | 1 |
| 12 | New natural gradient algorithms for c yclostationary sources 显示文摘 | Jafafi M G Alty S R Chambers J A | 2004 | Vision Image and Signal Processing IEE Proceedings2004，151，1： | 1 |
| 13 | Introduction显示文摘 | Jon Alti Benediktsson | 1999 | special issue on data fusion Geoscience and Remote Sensing1999，37，3： | 1 |
| 14 | How persistent is the impact of market timing on capital structure?显示文摘 | A Alti | 2006 | Journal of Finance2006，61，4： | 1 |
| 15 | Response of antioxidant system of freshwa- ter fish Oreochromis niloticus to acute and chronic metal (Cd, Cu, Cr, Zn, Fe) exposures 显示文摘 | ALTI G CANLI M | 2010 | Ecotoxicology and Environ- mental Safety2010，73，8： | 1 |
| 16 | Analgesic efficacy of tramadoi,pregabalin and ibuprofen in menthol-evoked cold hyperalgesia显示文摘 | Altis K Schmidtko A Angioni C | 2009 | PAIN2009，147，： | 1 |
| 17 | How Sensitive is Investment to Cash Flow When Financing is Frictionless? 显示文摘 | Alti Aydogan | 2003 | Journal of Finance2003，58，2： | 1 |
| 18 | How persistent is the impact of market timing on capital structure 显示文摘 | ALTI A | 2006 | The Journal of Finance2006，61，4： | 1 |
| 19 | How persistent is the impact of market timing on capital strcture? 显示文摘 | Alti Aydogan | 2006 | Journal of Finance2006，，16： | 1 |
| 20 | IPO Market Timing显示文摘 | Alti A | 2005 | Review of Financial Studies2005，，： | 1 |
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