|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bile acid signaling and biliary functions显示文摘This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor(TGR5), farnesoid X receptor(FXR), ursodeoxycholic acid(UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids,we will expand the review and include sections that are most recently known(within 5–7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events. | Hannah Jones Gianfranco Alpini Heather Francis | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 17 |
| 2 | Bile acid interactions with cholangiocytes显示文摘Cholangiocytes 在他们的顶端的膜暴露于胆汁酸的高集中。为胆汁酸的选择 transporter,顶端的钠胆汁酸 Cotransporter (ASBT )( 也叫作 Ibat;基因名字 Slc10a2 ) 在 cholangiocyte 上是局部性的顶端的膜。在 basolateral 膜上,四个运输系统被识别了(t-ASBT,多药抵抗(MDR ) 3,一个未辩别出的阴离子 exchanger 系统和器官的溶质 transporter (Ost ) 异侧 transporter, Ostalpha-Ostbeta。一起,这些单向性地搬运 ers 从管的胆汁的行动胆汁酸到发行量。cholangiocytes 吸收的胆汁酸为重新分泌物经由仙子胆管丛再循环回到 hepatocytes 进胆汁。这再循环在 hepatocytes 和 cholangiocytes 之间的胆汁酸被叫作 cholehepatic 分流小径。最近的研究建议 cholehepatic 分流小径可以由于额外的肝的阻塞在胆汁酸并且到改编的全面肝胆管运输作出贡献到长期的胆汁郁积。ASBT 被腺苷 3' 尖锐地调整, 5'-monophosphate (营地) 依赖者易位到顶端的膜并且由 phosphorylation 依赖的 ubiquitination 和 proteasome 降级。ASBT 被变化长期地响应胆汁的胆汁酸集中和煽动性的 cytokines 在基因表示调整。cholangiocyte ASBT 的另一潜在的功能是允许 cholangiocytes 取样胆汁的胆汁酸以便激活细胞内部的表明小径。在细胞内部的钙,蛋白质激酶 C (PKC ) , phosphoinositide 3-kinase (PI3K ) ,激活 mitogen 的蛋白质(地图) 激酶和细胞外的调整信号的蛋白质激酶(英皇家空军之阶级最低之兵) 的胆汁酸扳机变化细胞内部的信号。胆汁酸显著地改变 cholangiocyte 分泌物,增长和幸存。不同胆汁酸在 cholangiocyte 上有微分效果细胞内部发信号,并且在一些例子,扳机反对在 cholangiocyte 上完成分泌物,增长和幸存。在这些之上基于概念和观察, cholangiocyte 被建议了是为在肝的胆汁酸的原则目标房间。 | Xuefeng Xia Heather Francis Shannon Glaser Gianfranco Alpini Gene LeSage | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 3 | c-Met targeted therapy of cholangiocarcinoma显示文摘Cholangiocarcinoma continues to be a challenging disease to treat. Systemic therapy is used in unresectable disease, disease progression after surgery, and in the palliative setting. Unfortunately, results of multiple phase Ⅱ trials have rarely yielded positive results. As data on the molecular carcinogenesis of cholangiocarcinoma is developing, we are more able to understand the disease process and can use this understanding to create unique targeted therapies. We reviewed the role of c-Met/ hepatocyte growth factor (HGF) in the development of cholangiocarcinoma. Furthermore, we explored the use of the c-Met guided cascade as a target to treat cholangiocarcinoma. We reviewed the current use and options for future development of c-Met agents to treat this disease. | Matei P Socoteanu Frank Mott Gianfranco Alpini Arthur E Frankel | 2008 | World Journal of Gastroenterology2008，14，19： | 16 |
| 4 | Estrogens and the pathophysiology of the biliary tree显示文摘有关不同纸巾上的雌激素效果的科学框架在最后十年期间极其膨胀了,当时雌激素受体(嗯) 子类型被识别。雌激素是不仅必要的因为雌性生殖系统,而且他们也包括心血管系统,骨头,大脑和肝在另外的纸巾控制基本功能。最近,在他们调制 cholangiocytes 的增生的和分泌活动的地方,雌激素被显示了指向胆汁的树,上皮细胞衬里胆汁管。由在两雌激素受体(ER-alpha ) 并且(上扮演嗯贝它) 子类型,并且由激活 genomic 或 non-genomic 小径,雌激素在生长因素和 cytokines 的复杂的环起一个关键作用,它调制 cholangiocytes 的增生的反应损坏。明确地,雌激素激活细胞内部的发信号的串联[英皇家空军之阶级最低之兵( 1/2 )(细胞外的调整家族 ases ( 1/2 ),PI3- kinase/AKT (phosphatidylinositol-3' kinase/AKT )]典型地代表象象生长因素( IGF1 )一样的胰岛素那样的生长因素,神经生长因素( NGF )和脉管的内皮生长因素( VEGF ),因此加强他们的行动。另外,雌激素在增殖的 cholangiocytes 刺激不同生长因素的分泌物。这评论明确地处理与雌激素处于正常、病理学的条件由调制 cholangiocyte 功能的角色和机制有关的最近的进展。 | Domenico Alvaro Maria Grazia Mancino Paolo Onori Antonio Franchitto Gianfranco Alpini Heather Francis Shannon Glaset Eugenio Gaudio | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 5 | Cholangiocytes and blood supply显示文摘胆汁的树的微脉管的供应,仙子胆管丛(PBP ) ,源自肝的动脉树枝和流动进肝窦状隙。PBP 的详细三维的研究被使用扫描电子执行了显微镜学脉管的腐蚀演员组(SEMvcc ) 技术。认为 PBP 在支持胆汁的上皮的能分泌、吸收性的功能起一个基本作用,他们在常态和病理的组织被探索。正常的肝证明 PBP 安排在 extra-附近 -- 并且肝内的胆汁的树。在小门道, PBP 被日益增多地继续了它显示出一个更复杂的脉管的网络的额外的肝的 PBP 的 capillaries 的单个层描绘。在普通的管结扎(BDL ) 以后,胆汁管和 PBP 增长的进步修正被观察。PBP 介绍在许多胆汁管附近安排的一个三维的网络并且作为容器的捆出现,由有典型圆网孔结构的同类的直径的 capillaries 镇静。PBP 网络从显得正常的正弦曲线网络是容易可区分的。在 BDL 期间考虑 PBP 的庞大的延期,脉管的内皮生长因素(VEGF ) 起的可能的作用被评估。VEGF -- A, VEGF-C 和他们的相关受体高度出现了在 BDL 老鼠的增殖的 cholangiocytes 积极的免疫。到象肝的动脉结扎一样的 BDL 老鼠的 anti-VEGF-A 或 anti-VEGF-C 抗体的管理导致了一个减少的胆汁管团。rVEGF 的管理 -- 到 BDL 肝的动脉的 A 绑扎老鼠阻止了 cholangiocyte 增长和 VEGF 的减少 -- 表情作为与 BDL 控制老鼠相比。这些数据处于 cholangiocyte 增长的条件建议胆汁的树的动脉的血供给的角色,例如它发生在长期的胆汁郁积期间。在另一方面, VEGF 作为在 cholangiocytes 和 PBP endothelial 之间的串音的一个工具起的作用建议 VEGF 版本和功能的那操作能为肝的动脉或胆汁的树的损坏描绘的人的病理学的条件代表治疗学的策略。 | Eugenio Gaudio Antonio Franchitto Luigi Pannarale Guido Carpino Gianfranco Alpini Heather Francis Shannon Glaser Domenico Alvaro Paolo Onori | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 6 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 7 | Heterogeneity of the intrahepatic biliary epithelium显示文摘这评论的目的是在 apoptotic,增生的和分泌活动与变化构画出与胆汁的上皮的词法异质和对肝胃肠激素和肽和肝损伤的不同大小的胆汁管的异构的 pathophysiological 回答有关的最近的调查结果。因为胆汁的上皮细胞(cholangiocytes ) 是人的 cholangiopathies 的目标的识别,胆汁的功能的知识很快正在增加,它被胆汁管的增长 / 损坏在尺寸的一个小范围以内描绘。胆汁的上皮的唯一的解剖,形态学,神经分布和血管形成与在胆汁的树的不同区域以内的 cholangiocytes 的功能一致。在活体内模型[例如,胆汁管结扎( BDL ),部分肝切除术,胆汁酸,四氯化碳( CCl4 )或 alpha-naphthylisothiocyanate ( ANIT )喂]并且在活体内试验性的工具[例如,刚孤立小、大的 cholangiocytes 或肝内胆汁管单位( IBDU )和小、大的鼠科的 cholangiocytes 的主要文化]允许我们表明肝内的胆汁的上皮的词法、功能的异质。这些模型表明了微分分泌活动和异构的 apoptotic 和不同的大小的管的增生的回答。类似于限制为特定的大小的管的 cholangiocyte 增长 / 损害的动物模型,在人的肝疾病,胆汁管损坏支配特定的大小的胆汁管。与肝内的胆汁的上皮的功能的异质有关的未来研究可以与 cholangiopathies 为病人揭示新 pathophysiological 治疗。 | Shannon Glaser Heather Francis Sharon DeMorrow Gene LeSage Giammarco Fava Marco Marzioni Julie Venter Gianfranco Alpini | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 8 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 9 | Role of sex hormones in the modulation of cholangiocyte function显示文摘Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. | Romina Mancinelli Paolo Onori Sharon DeMorrow Heather Francis Shannon Glaser Antonio Franchitto Guido Carpino Gianfranco Alpini Eugenio Gaudio | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 10 | Secretin activa- tion of the apical NA + -dependent bile acid transporter is as- sociated with cholehepatic shunting in rats显示文摘 | ALPINI G GLASER S BAIOCCHI L | 2005 | Hepatology2005，41，5： | 1 |
| 11 | Recent advance in the isolation of liver cells显示文摘 | Alpini G Phillips JO Vorman B | 1994 | Hepatology1994，20，： | 1 |
| 12 | Postural control modifications induced by synchronized ice skating 显示文摘 | Alpini D Mattei V Schlecht H | 2008 | Sport Sci Health2008，，2： | 1 |
| 13 | Recent advances in the isolation of liver cells 显示文摘 | Alpini G Phillips J O Vroman B | 1994 | Hepatology1994，20，3： | 1 |
| 14 | The treatment of acute vertigo显示文摘 | Cearani A Alpini D Monti B | 2004 | l Neurol Sci2004，25，1： | 1 |
| 15 | Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth andsecretion of BDL rats through activation of PKC alpha显示文摘 | Alpini G Baiocchi L GIaser S | 2002 | Hepatology2002，35，5： | 1 |
| 16 | Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice显示文摘 | Ueno Y Alpini G Yahagi K | 2003 | Liver Int2003，23，6： | 1 |
| 17 | Tauroursodeoxy-cholate inhibits human cholangiocarcinoma growth via Ca 2+-,PKC-,and MAPK-dependent pathways显示文摘 | Alpini G KallnO N Phinizy JL | 2004 | Am J Physiol Gastrointest Liver Physiol2004，286，6： | 1 |
| 18 | Recent advance in the isolation of liver cells显示文摘 | Alpini G Phillips J Vorman B | 1994 | Hepatology1994，20，： | 1 |
| 19 | Recent advance in the isolation of liver cells显示文摘 | Alpini G Phillips JO Vorman B | 1994 | Hepatology1994，20，20： | 1 |
| 20 | Accumulation of maize γ-zein and γ-zein: KDEL to high levels in tobacco leaves and differential increase of BiP synthesis in transformants显示文摘 | Bellucci M Alpini A Paolocci F C L | 2000 | Theor Appl Genet2000，101，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员