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| 1 | Increased apoptosis and decreased density of medial smooth muscle cells in human abdominal aortic aneurysms显示文摘Objective To determine the increase of apoptosis and the decrease of smooth muscle cells (SMCs) density in human abdominal aortic aneurysms (AAA). Methods In situ terminal transferase-mediated dUTP nick end labeling (TUNEL) was employed to detect apoptosis of SMCs in patients with AAA (n=25) and normal abdominal aortae (n=10). Positive cells were identified by specific cell marker in combination with immunohistochemistry. Meanwhile SMC counting was performed by anti-α-actin immunohistostaining to compare the SMC density. Results TUNEL staining revealed that there was significantly increased apoptosis in AAAs (average 8.6%) compared with normal abdominal aortae (average 0.95%, P <0.01). Double staining showed that most of these cells were SMCs. Counting of α-actin positive SMCs revealed that medial SMC density of AAAs (37.5±7.6 SMCs /HPF) was reduced by 79.1% in comparison with that of normal abdominal aortae (179.2±16.1 SMCs /HPF,P <0.01). Conclusions Significantly increased SMCs of AAA bear apoptotic markers initiating cell death. Elevated apoptosis may result in a decreased density of SMCs in AAA,which may profoundly influence the development of AAA. | 张健 Jan Schmidt Eduard Ryschich Hardy Schumacher Jens R Allenberg | 2003 | Chinese Medical Journal2003，，10： | 6 |
| 2 | 腹主动脉瘤中层平滑肌细胞的凋亡研究显示文摘目的探讨腹主动脉瘤 (abdominalaorticaneurysm ,AAA)中层平滑肌细胞 (smoothmus clecells ,SMC)的凋亡与其数量减少的关系。方法采用原位DNA末端标记 (TUNEL)技术探察AAA(2 5例 )和正常腹主动脉 (10例 )组织中细胞凋亡的情况 ,并联合抗 CD3、抗 CD2 0、抗 CD6 8及抗α actin的免疫组化染色对凋亡的阳性染色进行复染 ,以确定其细胞类型 ;同时通过抗α actin免疫组化染色对AAA镜下SMC进行记数和观察。结果AAA中层SMC[(38± 8)SMC/HPF]较正常腹主动脉 [(179± 16 )SMC/HPF]减少 79 1% ,P <0 0 1。正常腹主动脉TUNEL阳性细胞约为 1 0 % ,AAA组织中则为 8 6 % ,P <0 0 1。免疫组化染色显示这些细胞多为SMC。结论AAA中层SMC的凋亡是SMC数量减少的重要原因。 | 张健 Schmidt Jan 张强 段志泉 Allenberg Jens.-R | 2003 | 中华普通外科杂志2003，18，4： | 3 |
| 3 | High prev- alence of peripheral arterial disease and corn orbidity- in6880primarycavepatients: Across sectional study 显示文摘 | Diehm C Schuster A Allenberg JR | 2004 | Atheroselerosis2004，172，1： | 1 |
| 4 | 30day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patient s:arandomised non-inferiority trial显示文摘 | Ringleb PA Allenberg J Bruckmarm H | 2006 | Lancet2006，368，： | 1 |
| 5 | 30 day results from the SPACE trial of stentprotected angioplasty versus carotid endarterectomy in symptomatic patients:a randomised non-inferiority trial显示文摘 | SPACE Collaborative Group Ringleb PA Allenberg J | 2006 | Lancet2006，368，： | 1 |
| 6 | High prevalence of pe- ripheral arterial disease and comorbidity in 6880 primary care patients: A cross sectional study显示文摘 | Diehm C Schuster A Allenberg JA | 2004 | Atherosclerosis2004，172，1： | 1 |
| 7 | Die Aortendissektion – Wann operieren, wann endoluminal therapieren?显示文摘 | G.M. Richter J.R. Allenberg H. Schumacher J. Hansmann C. Vahl S. Hagl | 2001 | Der Radiologe2001，，8： | 1 |
| 8 | Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years : a muhinational, prospective, randomised trial 显示文摘 | Eckstein HH Ringleb P Allenberg JR | 2008 | Lancet Neurol2008，7，10： | 1 |
| 9 | Klassifikation des infrarenalen Aortenaneurysmas ( AAA ) : endo- vaskulaere oder knventionelle Chirurgie 显示文摘 | ALLENBERG J R SCHUMACHER H KALLINOWSKI F | 1996 | Gef/~esschirurgie1996，1，1： | 1 |
| 10 | High prevalence of peripheral arterial disease and comorbidity in 6880 primary care patients:A cross sectional study 显示文摘 | Diehm C Schuster A Allenberg JR | 2004 | Atherosclerosis2004，172，1： | 1 |
| 11 | High prevalence of peripheral arterial disease and comorbidity in 6880 primary cave patients:Across sectional study显示文摘 | DICHM C SCHUSTER A ALLENBERG JR | 2004 | Atherosclerosis2004，172，1： | 1 |
| 12 | Results of theStent-Protected Angioplasty versus Carotid Endarterectomy(SPACE) study to treat symptomatic stenoses at 2 years:amultinational,prospective,randomised trial 显示文摘 | Eckstein HH Ringleb P Allenberg JR | 2008 | LancetNeurol2008，7，10： | 1 |
| 13 | High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients:cross-sectional study显示文摘 | Diehm C Schuster A Allenberg JR | 2004 | Atherosclerosis2004，172，1： | 1 |
| 14 | Results of the stent-protected Angioplasty versus Carotid Endarterectomy study to treat symptomatic stenoses at 2 years: a multinaltional prospective, randomized tria显示文摘 | ECKSTEIN HH RINGLEB P ALLENBERG JR | 2008 | Lancet Neruol2008，7，10： | 1 |
| 15 | High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients:cross -sectional study显示文摘 | Diehm C Schuster A Allenberg J R | 2004 | At herosclerosis2004，172，： | 1 |
| 16 | Thirty-day results from the SPACE trial of stent protected an-gioplasty versus carotid endarterectomy in symptomatic pa-tients:a randomised non-inferiority trial显示文摘 | RINGLEBPA ALLENBERG J BRUCKMANN H | 2006 | Lancet2006，368，： | 1 |
| 17 | Results of the stent-protected angioplasty versus carotid endar-terectomy(SPACE)study to treat symptomatic stenoses at 2years:a multinational,prospective,randomised trial显示文摘 | ECKSTEIN H H RINGLEB P ALLENBERG J R | 2008 | Lan-cet Neurol2008，7，： | 1 |
| 18 | 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a rando- mised non-inferiority trial 显示文摘 | Group SC Ringleb PA Allenberg J | 2006 | Lancet2006，368，9543： | 1 |
| 19 | Results of the stent-protected angioplasty versus carotid endarterectomy (space) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial 显示文摘 | Eckstein HH Ringleb P Allenberg JR | 2008 | Lancet Neurol2008，7，10： | 1 |
| 20 | High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross sectional study 显示文摘 | Diehm C Schuster A Allenberg JR | 2004 | Atherosclerosis2004，172，1： | 1 |
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