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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | CD133:molecule of the moment显示文摘 | Mizrak D Brittan M Alison MR | 2008 | J Pathol2008，214，： | 1 |
| 3 | The American phytopathological society molecular evidence that the extracellular cutinase PbcIs required for pathogenicity of pyrenopeziza brassicae on oilseed显示文摘 | Li D H Alison M A Johnstone K | 2003 | RapMPMI2003，16，6： | 1 |
| 4 | Antiepileptie drugs:Are women aware of interactions with oral contraceptivesand potential teratogenicity?显示文摘 | Alison M P Anne R D Kritzer J | 2009 | Epilepsy & Behavior2009，4，14： | 1 |
| 5 | Dissolved organic carbon and nitrogen relationships in forest litter as affected by nitrogen deposition 显示文摘 | Alison H M John D A | 2000 | Soil biology and biochemistry2000，32，： | 1 |
| 6 | Cultivar and environment effects on annual ryegrass forage yield,yield distribution,and nutritive value显示文摘 | Redfearn D D Venuto B C Pitman W D Alison M W Ward J D | 2002 | Crop Science2002，42，6： | 1 |
| 7 | Relationship among nigrostriatal denervation,parkinsonism,and dyskinesias in the MPTP primate model显示文摘 | DONATO A DI MONTE M D ALISON MCCORMACK | 2000 | Mov Disord2000，15，3： | 1 |
| 8 | A Case Study of Organizational Capac- ity in Nonprofit Community Sport 显示文摘 | Katie M Alison D | 2009 | Journal of Sport Man- agement2009，，45： | 1 |
| 9 | CD133 : Molecule of the mo-ment 显示文摘 | Mizrak D Brittan M Alison MR | 2008 | J Pathol2008，214，1： | 1 |
| 10 | The influence of biological soil crusts on dew deposition in Gurbantunggut desert,northwestern China显示文摘 | Zhang J Zhang Y M Alison D | 2009 | Journal of Hydrology2009，379，： | 1 |
| 11 | Strategic Distribution of Protective Proteins within Bran Layers of Wheat Protects the Nutrient-Rich Endosperm1[W][OA]显示文摘 | Jerkovic Ante Kriegel Alison M Bradner John R Atwell Brian J Roberts Thomas H Willows Robert D | 2010 | Plant Physiology2010，，3： | 1 |
| 12 | CD133: molecule of the mo- ment显示文摘 | Mizrak D Brittan M Alison MR | 2008 | J Pathol2008，214，1： | 1 |
| 13 | A global overview of drought and heat-induced tree mortality reveals emerging climate change risks for forests 显示文摘 | CRAIG D A ALISON K M HAROUN C | 2010 | Forest Ecology and Management2010，259，： | 1 |
| 14 | CD133:molecule of the moment显示文摘 | Mizrak D Brittan M Alison MR | 2008 | J Pathol2008，214，1： | 1 |
| 15 | CD133:molecule of the moment显示文摘 | MIZRAK D BRITTAN M ALISON M R | 2008 | J Pathol2008，214，1： | 1 |
| 16 | Covalent modification of carbon electrodes for vohammetric differentiation of dopamine and aseorbic acid显示文摘 | Alison J Alisa D Alan M | 1995 | Analytiea Chimica Acta1995，317，： | 1 |
| 17 | Carbon sequestration in temperate grassland ecosystems and the influence of management, climate and elevated CO2 显示文摘 | Jones M B Alison D | 2004 | New Phytologist2004，164，3： | 1 |
| 18 | Microfluidics and circulating tumor cells显示文摘 | Yi Dong Alison M Skelley Keith D Merdek | 2013 | The Journal of Molecular Diagnostics2013，15，2： | 1 |
| 19 | Seasonal variation and the immune response : a fish perspective 显示文摘 | Tim J B Kim D T Alison L M | 2007 | Fish Shellfish Immu- nol2007，22，： | 1 |
| 20 | Direct atomic force microscope imaging of EcoRI endonuclease site spe- cifically bound to plasmid DNA molecules 显示文摘 | Alison D P Kerper P S Doktycz M J | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
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