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| 1 | Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma显示文摘AIM: To study whether examination of CagA antibodies could increase the odds ratio for gastric cancer in a casecontrol study, and how often other serum markers of gastric cancer risk could be found in Helicobacter pylorinegative patients.METHODS: H pylori CagA and parietal cell antibodies(PCAs), and serum pepsinogen Ⅰ (SPGI) levels were compared between patients with gastric cancer and controls who received endoscopic examination due to reasons other than gastrointestinal malignancy.RESULTS: The odds ratio (OR) for gastric cancer was2.9 (95% CI 1.4-5.8) in H pylori+ patients, and 2.4 (95%CI 1.2-4.9) in CagA+ patients. When results of H pylori and CagA antibodies were combined, OR increased to5.0 (95% CI 2.5-10.0). Furthermore, if cardia cancer patients were excluded, the OR increased to 6.8 (95% CI3.1-14.8). Among patients with a low SPGI level, the OR was 12.0 (95% CI 4.1-35.3). However, the risk was significant only in the older age group. The number of patients with low SPGI was significantly higher in H pylori-/CagA+ patients as compared to other cancer patients.CONCLUSION: Examination of both H pylori and CagA antibodies increases the OR for gastric cancer in our casecontrol study. CagA antibodies are important in detecting previous H pylori infection in advanced atrophic gastritis or cancer when spontaneous decline of H pylori antibodies occurs. SPGI may be helpful in screening elderly gastric cancer patients. | Arto Kokkola Johanna Louhimo Pauli Puolakkainen Henrik Alfthan Caj Haglund Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 2 | Amniotie fluid S100B protein and erythropoietin in pregnancies at risk for fetal hypoxia 显示文摘 | Loukovaara M Teramo K Alfthan H | 2009 | Europ J Obstet Gynecol Reprod Biol2009，142，2： | 1 |
| 3 | A complexbetween PSA and a 1-antichymotrypsin is the major form of PSA in serum of patients with prostatic cancer:assay of the complex improves clinical sensitivity for cancer显示文摘 | Stenman U Leinonen J Alfthan H | 1991 | Cancer Res1991，51，1： | 1 |
| 4 | Apolipoprotein A-Ⅰ,apolipoprotein B,and apolipoprotein B/apolipoprotein A-Ⅰ ratio:reference intervals compared with values in different pathophysiological conditions from the FINRISK 2007 study显示文摘 | Leiviska J Sundvall J Alfthan G | 2011 | Clin Chim Acta2011，412，1112： | 1 |
| 5 | Serum estradiol,testosterone,and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young finnish men显示文摘 | Vaimaki V V Alfthan H Lvaska K K | 2004 | Clin Endoerinol Metab2004，89，8： | 1 |
| 6 | Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coro-nary heart disease显示文摘 | Pussinen PJ Nyyssonen K Alfthan G | 2005 | Arterioscler Thromb Vasc Biol2005，25，4： | 1 |
| 7 | Association between Serum Selenium and the Risk of Cancer显示文摘 | Alfthan G Huttunen JK | 1984 | Am J Epidemoil1984，120，： | 1 |
| 8 | A complex between prostate-specific antigen and alphal-antichymotrypsinis the major form of prostate specific antigen in serum of patients with prostate cancer: assay of the complex improves clinical sensitivity for cancer 显示文摘 | Stenman HU Leinonen J Alfthan H | 1991 | Cancer Res1991，51，： | 1 |
| 9 | A complex between prostate specific antigen and alphal-antichymotrypsin is the major form of prostate specific antigen in serum of patients with prostate cancer:Assay of the complex improves clinical sensitivity for cancer显示文摘 | Stenman UH Leinonen J Alfthan H | 1991 | Cancer Res1991，51，1： | 1 |
| 10 | Antibodies to periodontal pathogens and stroke risk显示文摘 | Pussinen PJ Alfthan G Rissanen H | 2004 | Stroke2004，35，9： | 1 |
| 11 | etal,plasma kinetics and urina- ry excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice显示文摘 | Erlund I meririnne E Alfthan G | 2001 | J nutr2001，，： | 1 |
| 12 | High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction显示文摘 | Pussinen PJ Alfthan G Tuomilehto J | 2004 | Eur J C ardiovasc Prey Rehabil2004，11，5： | 1 |
| 13 | A complex between prostate - specific antigen and alphal - antichymotrypsinis the major form of prostate specific antigen in serum of patients with prostate cancer: assay of the complex improves clinical sensitivity for cancer显示文摘 | STENMAN H U LEINONEN J ALFTHAN H | 1991 | Cancer Res1991，51，： | 1 |
| 14 | Preoperative hCG beta and CA72-4 are prognostic factors in gastric cancer显示文摘 | Louhimo J Kokkola A Alfthan H ctal | 2004 | Int J Cancer2004，111，6： | 1 |
| 15 | Vitamin D sta- tus as a determinant of peak bone mass in young Finnish men 显示文摘 | Vaimaki VV Alfthan H Lehmuskallio E | 2004 | The Journal Clinical Endocrinology and Metabolism2004，89，1： | 1 |
| 16 | Serum tumour markers CA15-3, TPA, TPS, hCGbeta and TATI in the monitoring of chemotherapy response in metastatic breast cancer 显示文摘 | Sjostrom J Alfthan H Joensuu H | 2001 | Scand J Clin Lab Invest2001，61，6： | 1 |
| 17 | Comparison of immunoradiometrie and immunofluorumetrie assays for serum Hcg 显示文摘 | Alfthan H | 1986 | J Immunol Methods1986，88，2： | 1 |
| 18 | An ultrasensitive time-resolved immunofluorometric assay of human epidermal growth factor显示文摘 | PESONEN K ALFTHAN H STENMAN U H | 1986 | Anal Biochem1986，157，2： | 1 |
| 19 | A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer:assay of the complex improves clinical sensitivity for cancer显示文摘 | Stenman U H Leinonen J Alfthan H | 1991 | Cancer Res1991，51，1： | 1 |
| 20 | Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes:the Botnia Dietary Study 显示文摘 | YLONEN K ALFTHAN G GROOP L | 2003 | Am J Clin Nutr2003，77，6： | 1 |
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