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| 1 | 灯盏花素的抗氧化作用及拮抗硒对大鼠肝脏毒性的研究显示文摘目的 探讨灯盏花素对人类允许的最高摄入量 (UL upperlimitofintake)硒所致毒性的拮抗作用。 方法 采用体外化学发光法测定灯盏花素清除亚硒酸钠 (Na2 SeO3)产生的活性氧自由基 (ROS)的能力、动物模型研究灯盏花素对大鼠肝脏丙二醛 (MDA)含量、抗氧化酶活性及组织病理学损伤的影响。结果 体外实验表明灯盏花素能有效清除由Na2 SeO3产生的ROS。动物实验中补UL硒及灯盏花素组大鼠肝脏MDA含量低于仅补UL硒组 ;超氧化物歧化酶(SOD)、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH Px)活性高于仅补UL硒组 ;肝组织切片显示受损伤程度与仅补UL硒组相比减轻。结论 灯盏花素能有效拮抗UL硒所致的毒性 。 | Ali Abdella 甘璐 刘琼 刘宏 徐辉碧 | 2003 | 中国药理学通报2003，19，1： | 53 |
| 2 | 大剂量硒降低硒酶基因表达并致大鼠肝组织损伤显示文摘目的 : 探讨补充大剂量硒对谷胱甘肽过氧化物酶和硫氧还蛋白还原酶基因表达和酶活性的影响、以及对大鼠肝组织的作用。方法 : 给大鼠腹腔分别注射 0 ,2 0 ,40和 80 μg/ (kg·d)亚硒酸钠 -生理盐水 1 5d,取肝脏做组织切片 ,再将肝组织匀浆后通过反转录聚合酶链式反应半定量检测不同剂量亚硒酸钠对硒酶基因表达的影响 ,同时测定硒酶活性、肝组织硒含量及丙二醛含量。结果 : 补充亚硒酸钠 2 0 μg/ (kg· d)的鼠肝中 ,两类硒酶的 m RNA丰度及酶活性均增高 ,而补充 40和 80 μg/ (kg· d)亚硒酸钠的大鼠 ,两类硒酶的 m RNA丰度及酶活性均显著下降 (P<0 .0 5) ,且随补硒剂量升高下降幅度增大。而鼠肝硒含量则随补硒剂量升高而显著性增大 (P<0 .0 5)。与对照组相比 ,补充 40μg / (kg· d)亚硒酸钠的鼠肝脂质过氧化水平增高 (P<0 .0 1 ) ,肝组织在形态学上发生病变。结论 : 大剂量补硒降低鼠肝谷胱甘肽过氧化物酶和硫氧还蛋白还原酶基因表达和酶活性 ,并造成肝组织损伤。 | 刘琼 甘璐 Abdella A li 徐辉碧 | 2003 | 营养学报2003，25，4： | 10 |
| 3 | 灯盏花素对UL补硒大鼠谷胱甘肽过氧化物酶和硫氧还蛋白还原酶基因表达和活性的影响显示文摘目的 观察灯盏花素对允许的最高摄入量硒大鼠肝脏、肾脏、睾丸组织中谷胱甘肽过氧化物酶 (GSH Px)和硫氧还蛋白还原酶 (TR)基因表达和活性的影响。方法 采用RT PCR方法和酶活性测定分析GSH Px和TR基因表达水平和活性。结果 UL硒能降低大鼠肝脏组织中GSH Px和TRmRNA表达水平及活性 ,灯盏花素能增加补硒大鼠肝脏中GSH Px和TRmRNA表达水平和活性。UL硒对大鼠肾脏、睾丸组织GSH Px和TRmRNA表达水平和活性无明显影响。结论 灯盏花素能有效拮抗UL硒所致的GSH Px和TRmRNA表达和活性的下降 ,且UL硒所致的GSH Px和TRmRNA表达和活性的下降具有组织特异性。 | Ali Abdella 甘璐 刘琼 刘宏 徐辉碧 | 2003 | 中国药理学通报2003，19，10： | 9 |
| 4 | Outcome of non surgical hepatic decompression procedures in Egyptian patients with Budd-Chiari显示文摘AIM: To evaluate outcome of patients with Budd-Chiari syndrome after balloon angioplasty ± stenting or transjugular intrahepatic portosystemic shunt (TIPS). METHODS: Twenty five patients with Budd-Chiari syndrome admitted to Ain Shams University Hospitals, Tropical Medicine Department were included. Twelve patients (48%) with short segment occlusion were candidates for angioplasty; with stenting in ten cases and without stenting in two. Thirteen patients (52%) had Transjugular Intrahepatic Portosystemic Shunt. Patients were followed up for 12-32 mo. RESULTS: Patency rate in patients who underwent angioplasty ± stenting was 83.3% at one year and at end of follow up. The need of revision was 41.6% with one year survival of 100%, dropped to 91.6% at end of follow up. In patients who had Transjugular Intrahepatic Portosystemic Shunt, patency rate was 92.3% at one year, dropped to 84.6% at end of follow up. The need of revision was 38.4% with one year and end of follow up survival of 100%. Patients with patent shunts showed marked improvement compared to those with occluded shunts. CONCLUSION: Morbidity and mortality following angioplasty ± stenting and TIPS are low with satisfactory outcome. Proper patient selection and management of shunt dysfunction are crucial in improvement. | Ahmed Eldorry Eman Barakat Heba Abdella Sara Abdelhakam Mohamed Shaker Amr Hamed Mohammad Sakr | 2011 | World Journal of Gastroenterology2011，17，7： | 3 |
| 5 | Serum lipo-protein(a) concentration as a cardiovascular risk factor in Ku-waiti type 2 diabetic patients 显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2001 | J Diabetes Complications2001，15，5： | 1 |
| 6 | Which obesity index best explains the link between adipokines, coronary heart disease risk and metabolic abnormalities in type 2 diabetes mellitus? 显示文摘 | Mojiminiyi OA Al Mulla F Abdella Na | 2009 | Med Princ Pract2009，18，： | 1 |
| 7 | Evaluation of serum squamous cell carcinoma antigen as a novel biomarker for diagnosis of hepatocellular carcinoma in Egyptian patients 显示文摘 | Hussein MM Ibrahim AA Abdella HM | 2008 | Indian J Cancer2008，45，4： | 1 |
| 8 | Plasma leptin concentration in patients with Type 2 diabetes:relationship to cardiovascular disease risk factors and insulin resistanee显示文摘 | Abdella NA | 2005 | Diabetic Medicine2005，22，2： | 1 |
| 9 | Associations of plasma homocysteine concentration in subjects with type 2 diabetes mellitus显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2002 | Acta Diabetol2002，39，： | 1 |
| 10 | Evaluation of cystatin C and beta-2 microglobulin as markers of renal function in patients with type 2 diabetes mellitus显示文摘 | Mojiminiyi OA Abdella N | 2003 | J Diabetes Complications2003，17，3： | 1 |
| 11 | Evaluation of serum cystatin C and chromogranin A as markers of nephropathy in patients with type 2 diabetes mellitus显示文摘 | Abdella N George S | 2000 | Scand J Clin Lab Invest2000，60，6： | 1 |
| 12 | Homocysteine and endogenous markers of renal function in type 2 diabetic patients without coronary heart disease显示文摘 | ABDELLA N MOJIMINIYI O A AKANJI A O | 2000 | Diabetes Res Clin Pract2000，50，： | 1 |
| 13 | Association of C-reactive protein with coronary heart disease risk factors in patients with type 2 diabetes mellitus显示文摘 | Mojiminiyi OA Abdella N Moussa MA | 2002 | Diabetes Res Clin Pract2002，58，1： | 1 |
| 14 | The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbAlc levels: an observational cross-sectional study 显示文摘 | El Lithy A Abdella R M E1-Faissal Y M | 2014 | BMC Pregnancy Childbirth2014，14，： | 1 |
| 15 | Association of Creactive protein with coronary heart disease risk factors in patients with type 2 diabetes mellitus显示文摘 | Mojiminiyi O A Abdella N Moussa M A | 2002 | Diabetes Res Clin Pract2002，58，： | 1 |
| 16 | Eyaluation of cystatin C and be-ta-2 microglobulin as markers of renal function in patients withtype 2 diabets mellitus显示文摘 | MOJIMINIYI O A ABDELLA N | 2003 | J Diabets Complications2003，17，3： | 1 |
| 17 | Evaluation of cystatin C and beta-2 microglobulin as markers of renal function in patients with type 2 diabetes mellitus 显示文摘 | Mojiminiyi OA Abdella N | 2003 | JDiabetes Complications2003，17，3： | 1 |
| 18 | The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine statu显示文摘 | Hamed SA Abdella MM | 2009 | Epilepsy Res2009，86，： | 1 |
| 19 | Plasma leptin concentration in patients with type 2 di- abetes: relationship to cardiovascular diseaserisk factors andinsulin resistance显示文摘 | ABDELLA N A MOJIMINIYI O A MOUSSA M A | 2005 | Diabet Med2005，22，3： | 1 |
| 20 | Social and psychological characteristics of Kuwaiti children and adolescents with type 1 diabetes显示文摘 | Moussa MMA Alsaeid M Abdella N | 2005 | Social Science & Medicine2005，60，： | 1 |
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