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| 1 | Review of magnesium-based biomaterials and their applications显示文摘In biomedical applications,the conventionally used metallic materials,including stainless steel,Co-based alloys and Ti alloys,often times exhibit unsatisfactory results such as stress shielding and metal ion releases.Secondary surgical operation(s)usually become inevitable to prevent long term exposure of body with the toxic implant contents.The metallic biomaterials are being revolutionized with the development of biodegradable materials including several metals,alloys,and metallic glasses.As such,the nature of metallic biomaterials are transformed from the bioinert to bioactive and multi-biofunctional(anti-bacterial,anti-proliferation,anti-cancer,etc.).Magnesium-based biomaterials are candidates to be used as new generation biodegradable metals.Magnesium(Mg)can dissolve in body fluid that means the implanted Mg can degrade during healing process,and if the degradation is controlled it would leave no debris after the completion of healing.Hence,the need for secondary surgical operation(s)for the implant removal could be eliminated.Besides its biocompatibility,the inherent mechanical properties of Mg are very similar to those of human bone.Researchers have been working on synthesis and characterization of Mg-based biomaterials with a variety of composition in order to control the degradation rate of Mg since uncontrolled degradation could result in loss of mechanical integrity,metal contamination in the body and intolerable hydrogen evolution by tissue.It was observed that the applied methods of synthesis and the choice of components affect the characteristics and performance of the Mg-based biomaterials.Researchers have synthesized many Mg-based materials through several synthesis routes and investigated their mechanical properties,biocompatibility and degradation behavior through in vitro,in vivo and in silico studies.This paper is a comprehensive review that compiles,analyses and critically discusses the recent literature on the important aspects of Mg-based biomaterials. | Nurettin Sezer Zafer Evis Said Murat Kayhan Aydin Tahmasebifar Muammer Koça | 2018 | Journal of Magnesium and Alloys2018，6，1： | 38 |
| 2 | Total thyroidectomy is safer with identification of recurrent laryngeal nerve显示文摘Objective:To investigate the effect of recurrent laryngeal nerve(RLN)identification on the complications after total thyroidectomy and lobectomy.Methods:Total 134 consecutive patients undergoing total thyroidectomy or thyroid lobectomy from January 2003 to November 2004 were investigated retrospectively.Patients were divided into two groups:RLN identified (Group A)or not(Group B).The two groups were compared for RLN injury and hypocalcaemia.Results:The numbers of patients and nerves at risk were 71 and 129 in Group A,and 63 and 121 in Group B,respectively.RLN injury in Group A(0)was sig- nificantly lower than that in Group B(57.9%)patients,75.8%nerves)for the numbers of patients(P=0.016)and nerves at risk (P=0.006).Temporary hypocalcaemia was significantly higher in Group A than in Group B(1424.1%vs 610.3%,P=0.049). Permanent complications in Group B were significantly higher than those in Group A(1320.6%vs 45.6%,P=0.009).Con- clusion:RLN injury was prevented and permanent complications were decreased by identifying the whole course and branches of the recurrent laryngeal nerve during total thyroidectomy. | Hakan CANBAZ Musa DIRLIK Tahsin COLAK Koray OCAL Tamer AKCA Oner BILGIN Bahar TASDELEN Suha AYDIN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，6： | 20 |
| 3 | Clinical probability and risk analysis of patients with suspected pulmonary embolism显示文摘BACKGROUND: Pulmonary embolism(PE) is one of the most frequent diseases that could be missed in overcrowded emergency departments as in Turkey. Early and accurate diagnosis could decrease the mortality rate and this standard algorithm should be defi ned. This study is to fi nd the accurate, fast, non-invasive, cost-effective, easy-to-access diagnostic tests, clinical scoring systems and the patients who should be tested for clinical diagnosis of PE in emergency department.METHODS: One hundred and forty patients admitted to the emergency department with the fi nal diagnosis of PE regarding to anamnesis, physical examination and risk factors, were included in this prospective, cross-sectional study. The patients with a diagnosis of pulmonary embolism, acute coronary syndrome or infection and chronic obstructive pulmonary disease(COPD) were excluded from the study. The demographics, risk factors, radiological fi ndings, vital signs, symptoms, physicallaboratory fi ndings, diagnostic tests and clinical scoring systems of patients(Wells and Geneva) were noted. The diagnostic criteria for pulmonary emboli were: fi lling defect in the pulmonary artery lumen on spiral computed tomographic angiography and perfusion defect on perfusion scintigraphy.RESULTS: Totally, 90(64%) of the patients had PE. Age, hypotension, having deep vein thrombosis were the risk factors, and oxygen saturation, shock index, BNP, troponin and fi brinogen levels as for the biochemical parameters were signifi cantly different between the PE(+) and PE(–) groups(P<0.05).The Wells scoring system was more successful than the other scoring systems.CONCLUSION: Biochemical parameters, clinical findings, and scoring systems, when used altogether, can contribute to the diagnosis of PE. | Gulden Ozeren Yetgin Sule Akkose Aydin Ozlem Koksal Fatma Ozdemir Dilek Kostak Mert Gokhan Torun | 2014 | World Journal of Emergency Medicine2014，5，4： | 20 |
| 4 | Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients显示文摘AIM:To investigate the therapeutic efficacy and safety of continuous autotransfusion system(CATS) during liver transplantation of hepatocellular carcinoma patients.METHODS:Eighty-three hepatocellular carcinoma(HCC) patients who underwent liver transplantation with intraoperative CATS(n = 24,CATS group) and without(n = 59,non-CATS group) between April 2006 and November 2011 at the Liver Transplant Institute of Inonu University were analyzed retrospectively.Postoperative HCC recurrence was monitored by measuring alpha-fetoprotein(AFP) levels at 3-mo intervals and performing imaging analysis by thoracoabdominal multidetector computed tomography at 6-month intervals.Inter-group differences in recurrence and correlations between demographic,clinical,and pathological data were assessed by ANOVA and χ 2 tests.Overall and disease-free survivals were calculated by the univariate Kaplan-Meier method.RESULTS:Of the 83 liver transplanted HCC patients,89.2% were male and the overall mean age was 51.3 ± 8.9 years(range:18-69 years).The CATS and nonCATS groups showed no statistically significant differences in age,sex ratio,body mass index,underlying disease,donor type,graft-to-recipient weight ratio,Child-Pugh and Model for End-Stage Liver Disease scores,number of tumors,tumor size,AFP level,Milan and University of California San Francisco selection criteria,tumor differentiation,macrovascular invasion,median hospital stay,recurrence rate,recurrence site,or mortality rate.The mean follow-up time of the nonCATS group was 17.9 ± 12.8 mo,during which systemic metastasis and/or locoregional recurrence developed in 25.4% of the patients.The mean follow-up time for the CATS group was 25.8 ± 15.1 mo,during which systemic metastasis and/or locoregional recurrence was detected in 29.2% of the patients.There was no significant difference between the CATS and non-CATS groups in recurrence rate or site.Additionally,no significant differences existed between the groups in overall or disease-free survival.CONCLUSION:CATS is a safe procedure and may decrease the risk of tumor recurrence in HCC patients. | Sami Akbulut Cuneyt Kayaalp Mehmet Yilmaz Volkan Ince Dincer Ozgor Koray Karabulut Cengiz Eris Huseyin Ilksen Toprak Cemalettin Aydin Sezai Yilmaz | 2013 | World Journal of Gastroenterology2013，19，10： | 17 |
| 5 | Pulmonary involvement in inflammatory bowel disease显示文摘AIM:To determine the relationship of pulmonary abnormalities and bowel disease activity in inflammatory bowel disease(IBD).METHODS:Thirty ulcerative colitis(UC)and nine Crohn's disease patients,and 20 control subjects were enrolled in this prospective study.Detailed clinical information was obtained.Extent and activity of the bowel disease were established endoscopically.Each patient underwent pulmonary function tests and high-resolution computed tomography(HRCT).Blood samples for measurement of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),angiotensin converting enzyme and total IgE were delivered by the patients.RESULTS:Ten(25.6%)patients had respiratory symptoms.A pulmonary function abnormality was present in 22 of 39 patients.Among all patients,the most prevalent abnormalities in lung functions were a decrease in forced expiratory volume in 1 s(FEV1),FEV1/forced vital capacity(FVC),forced expiratory flow(FEF)25%-75%,transfer coefficient for carbon monoxide(DLCO),DLCO/alveolar volume.Increased respiratory symptoms score was associated with high endoscopic activity index in UC patients.Endoscopic and clinical activities in UC patients were correlated with FEV1,FEV1/FVC,and FEF 25%-75%.Smoking status,duration of disease and medication were not correlated with pulmonary physiological test results,HRCT abnormalities,clinical/endoscopic disease activity,CRP,ESR or total IgE level or body mass index.CONCLUSION:It is important that respiratory manifestations are recognized and treated early in IBD.Otherwise,they can lead to destructive and irreversible changes in the airway wall. | Aydin Yilmaz Nilgün Yilmaz Demirci Derya Hosgün Enver ner Yurdanur Erdogan Atila Gkek Atalay aglar | 2010 | World Journal of Gastroenterology2010，16，39： | 15 |
| 6 | Long-term vision-threatening complications of phakic intraocular lens implantation for high myopia显示文摘AIM:To report the long-term vision-threatening complications in patients who underwent phakic intraocular lens(pIOLs)implantation for high myopia.METHODS:Thisstudywasdesignedfromaconsecutive series of phakic intraocular lens complication and corrective surgeries.Sixteen eyes of 13 patients had implantation of phakic intraocular lens for correction high myopia and developed serious complications have been included in this study.The mean age of patients was 38.6±6.35y(range 32-50y)and the mean time of history of pIOL implantation for high myopia was 6±2y(range 2-10y).Before corrective surgery,best spectaclecorrective visual acuity(BSCVA)ranged from perception to 20/200 in the eyes in which severe complications occurred.RESULTS:Corneal decompensation occurred in 12eyes of 9 high myopic patients after anterior chamber pIOL implantation.Rhegmatogenous retinal detachment(RRD)occurred in 4 eyes of 4 high myopic patients following anterior chamber and posterior chamber pIOL implantation.Patients with corneal decompensation,had combined procedures consisting of pIOL removal and penetrating keratoplasty(PKP).Removals of pIOL,phacoemulsification and pars plana vitrectomy(PPV)with silicone oil tamponade were performed in patients with RRD.After corrective surgeries,all patients but one(P+,patient 2,right eye)achieved moderate BSCVA ranged from 20/200 to 20/50 at the last visit.CONCLUSION:Phakic IOLs may be effective for thecorrection of high myopia.Although these IOLs may have severe complications and it affects safety and efficacy of this surgery.As seen here,corneal decompensation and rhegmatogenous retinal detachment are possible postoperative vision-threatening complications of phakic IOLs.Patients must be carefully examined before and after surgery for possible endothelial cell loss and vitreoretinal problems. | Isil Bahar Sayman Muslubas Baran Kandemir Ayse Yesim Aydin Oral Suleyman Kugu Metin Dastan | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 14 |
| 7 | 青光眼视网膜神经纤维层厚度的光学相干断层扫描纵向评估显示文摘目的:纵向评估光学相干断层扫描(OCT)视盘周围神经纤维层厚度测量,并将这些检查与临床状态和自动视野计检查作横向比较。
方法:对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼(37例)作回顾性评估。所有参与者每6个月作一次全面的临床评估、视野检查和OCT。视野进展按可重复性测量的视野平均偏差至少比基线降低2dB,OCT进展按可重复性测量视网膜神经纤维层平均厚度至少变薄20pro。
结果:每个患者在中位值为4.7年的随访中有5个可使用的OCT扫描。青光眼和疑似青光眼患者之间视网膜神经纤维层厚度线性回归斜度的差异对所有变量均不显著;然而,Kaplan-Meier生存曲线分析显示视野比OCT测量有较高的进展率。在随访期间66%的眼是稳定的。22%只有OCT进展,9%单有视野平均偏差进展。3%视野和OCT都有进展。
结论:OCT比全自动视野计对辨别青光眼进展有更大的可能性。这可能反映OCT的敏感性或在常规方法发现之前其真实损害就能被OCT发现。 | Gadi Wollstein Joel S. Schuman Lori L. Price Ali Aydin Paul C. Stark Ellen Hertzmark Edward Lai Hiroshi Ishikawa Cynthia Mattox James G. Fujimoto Lelia A. Paunescu 刘春(译) 朱志忠(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 14 |
| 8 | Expression of bcI-2 gene family during resection induced liver regeneration:Comparison between hepatectomized and sham groups显示文摘AIM:During liver regeneration cellular proliferation and apoptosis result in tissue remodeling to restore normal hepatic mass and structure.Main regulators of the apoptotic machinery are the Bcl-2 family proteins but their roles are not well defined throughout the liver regeneration.We aimed to analyze the expression levels of bcl-2 gene family members during resection induced liver regeneration.METHODS:We performed semi-quantitative RT-PCR to examine the expression level of bak, bax, bcl-2 and bcl-XL in 70% hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups.RESULTS:The expression of bak and baxwas decreased whereas that of bcl-2 and bcl-XL was increased in hepatectomized animals compared to normal liver at most time points.We also reported for the first time that sham group of animals had statistically significant higher expression of bak and bax than hepatectomized animals.In addition, the area under the curve (AUC) values of these genes was larger in sham groups than the hepatectomized groups.CONCLUSION: The expression changes of bak, bax, bcl-2 and bcl-XL genes are altered not only due to regeneration,but also due to effects of surgical operations. | Kamil Can Akcali Aydin Dalgic Ahmet Ucar Khemaeis Ben Haj Dilek Guvenc | 2004 | World Journal of Gastroenterology2004，10，2： | 13 |
| 9 | Three-dimensional MR and axial CT colonography versus conventional colonoscopy for detection of colon pathologies显示文摘瞄准:在检测冒号损害评估先生 colonography (MRC ) 和 CT 性能的敏感和特性,并且把他们的敏感和特性与常规结肠镜检查的作比较。方法:怀疑有结肠的损害的 42 个病人因为直肠的流血,积极烘便的潜血测试结果或改变的肠习惯,经历了考试。在一个直肠的试管的插入以后,冒号充满 9 g/L NaCl 答案, 0.5 mmol/L gadopentetate dimeglumine 的 15-20 mL 和 iodinized 对比材料的 100 mL 的混合物的 1000-1500 mL。为先生 colonography 和互补先生图象的从前结肠的扩张被完成的、三维的坡度回响(3D-GRE ) 序列在所有情况中被拿。立即在先生 colonography 以后,腹的 CT 图象被螺线 CT 拿在里面轴并且背卧位。然后,所有病人被常规结肠镜检查(CC ) 检查。结果:为冒号病理的 MRC 的敏感和特性是 96.4% 并且 100% 分别地。由 MRC 的正确诊断的百分比是 97.6% 。百分之百,为冒号病理的 CT 的敏感和特性分别地是 92.8% 。由 CT 的正确诊断的百分比是 95.2% 。结论:在检测冒号损害, MRC 完成了类似于 CC 的诊断精确性。然而, MRC 是最低限度地侵略的,没有对在调查期间的镇静或止痛剂的需要。有穿孔风险的一个更低的百分比,并且所有冒号片断能由于多部分的成像可获得性被评估;结肠的损害,转移和任何另外的损害的内部、额外肠的部件能容易被评估。MRC 和 CT colonography 是答应在颜色的察觉高度敏感的新放射学的技术表面的集体、煽动性的肠损害。 | Rahime Haykir Serdar Karakose Aydin Karabacakoglu Mustafa Sahin Ertugrul Kayacetin | 2006 | World Journal of Gastroenterology2006，12，15： | 12 |
| 10 | Effect of Intercritical Annealing Parameters on Dual Phase Behavior of Commercial Low-Alloyed Steels显示文摘The effects of some intercritical annealing parameters including heating rate,soaking temperature,soaking time,and quench media on the microstructure and mechanical properties of cold-rolled dual phase steel were studied.The microstructure of specimens quenched after each annealing stage was analyzed using optical microscope.The tensile properties,determined for specimens submitted to complete annealing cycles,were influenced by the volume fractions of multiphases(originated from martensite,bainite,and retained austenite),which depend on the annealing process parameters.The results obtained showed that the yield strength and the ultimate tensile strength increase with increasing the intercritical temperature and cooling rate.This can be explained by higher martensite volume ratio with the increased volume fraction of austenite formed at the higher temperatures and cooling rates. | Aydin Hüseyin Kazdal Zeytin Havva Kubilay Ceylan | 2010 | Journal of Iron and Steel Research(International)2010，17，4： | 10 |
| 11 | N-acetylcysteine attenuates alcohol-induced oxidative stess in rats显示文摘AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，4： | 9 |
| 12 | Is obstructive sleep apnea syndrome a risk factor for pulmonary thromboembolism?显示文摘 | Kezban Ozmen Suner AliNihat Annakkaya Umran Toru Talha Dumlu Ege Gulec Balbay Peri Arbak Leyla Yilmaz Aydin Hasan Suner | 2012 | Chinese Medical Journal2012，，20： | 9 |
| 13 | Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium. | Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 9 |
| 14 | Performance of a novel bent-up bars system not interacting with concrete显示文摘Increasing the bending and shear capacities of reinforced concrete members is an interesting issue in structural engineering.In recent years,many studies have been carried out to improve capacities of reinforced concrete members such as using post and pre-tensioning,Fiber Reinforced Polymer and other techniques.This paper proposes a novel and significant technique to increase the flexural capacity of simply supported reinforced concrete beams.The proposed method uses a new reinforcement bar system having bent-up bars,covered with rubber tubes.This technique will avoid interaction of bent-up bars with concrete.They are located in the zone where compressive and tensile forces act against one anothe匚The compressive force in the upper point of the bent-up bars is exerted to the end point of these bars located under neutral axis.Moreover,the tensile stress is decreased in reinforcements located under the neutral axis.This will cause the Reinforced Concrete(RC)beam to endure extra loading before reaching yield stress.These factors may well be considered as reasons to increase bending capacity in the new system.The laboratory work together with finite element method analysis were carried out in this investigation.Furthermore,bending capacity,ductility,strength,and cracking zone were assessed for the new proposed system and compared with the conventional model.Both the FEM simulation and the experimental test results revealed that the proposed system has significant impact in increasing the load bearing capacity and the stiffness of the RC beams.In the present study,an equation is formulated to calculate bending capacity of a new reinforcement bar system beam. | Aydin SHISHEGARAN Mohammad Reza GHASEMI Hesam VARAEE | 2019 | Frontiers of Structural and Civil Engineering2019，13，6： | 8 |
| 15 | 岩石蠕变模型的比较和修正显示文摘对三种岩石在不同的应力下进行了蠕变实验,对蠕变实验曲线用粘弹模型进行了模型参数的反演,结果认为标准线性体、伯格斯和对数模型都是实验曲线的很好近似。为了进一步了解蠕变实验时间对模型参数的影响,研究了蠕变模型的预测功能。将实验蠕变曲线分成二部分,第一部分用于模型参数的反演,第二部分用于模型预测数据的检验。时间外延所得的模型的预测曲线都明显偏离了实测曲线,伯格斯和对数模型的预测曲线比实测曲线偏高,而标准线性体模型则偏低。根据不同时间的蠕变实验数据的比较和分析,认为实验时间对蠕变模型参数的反演有较为明显的影响,但只要对标准线性体模型作适当修正,引入与时间尺度有关的函数C(t),则该模型的预测能力就有较大的提高。 | 李成波 Adnan Aydin 施行觉 王行舟 | 2008 | 实验力学2008，23，1： | 8 |
| 16 | Percutaneous peritoneal drainage in isolated neonatal gastric perforation显示文摘A comment on the article by He et al, 'Idiopathic neonatal pneumoperitoneum with favorable outcome:A case report and review', published on World Journal of Gastroenterology that reported a case of idiopathic neonatal pneumoperitoneum, possibly due to gastric perforation, with a favorable outcome without surgical intervention. | Mustafa Aydin Ugur Deveci Erdal Taskin Unal Bakal Mehmet Kilic | 2015 | World Journal of Gastroenterology2015，21，45： | 8 |
| 17 | Management and therapy of vasovagal syncope: A review显示文摘Vasovagal syncope is a common cause of recurrent syncope. Clinically, these episodes may present as an isolated event with an identifiable trigger, or manifest as a cluster of recurrent episodes warranting intensive evaluation. The mechanism of vasovagal syncope is incompletely understood. Diagnostic tools such as implantable loop recorders may facilitate the identification of patients with arrhythmia mimicking benign vasovagal syncope. This review focuses on the management of vasovagal syncope and discusses the non-pharmacological and pharmacological treatment options, especially the use of midodrine and selective serotonin reuptake inhibitors. The role of cardiac pacing may be meaningful for a subgroup of patients who manifest severe bradycardia or asystole but this still remains controversial. | Muhammet Ali Aydin Tushar V Salukhe Iris Wilke Stephan Willems | 2010 | World Journal of Cardiology2010，2，10： | 8 |
| 18 | Gastric polypoid lesions:Analysis of 150 endoscopic polypectomy specimens from 91 patients显示文摘AIM: To analyze gastric polypoid lesions in our patientpopulation with respect to histopathologic features and demographic, clinical, and endoscopic characteristics of patients.METHODS: Clinical records and histopathologic reports of patients with gastric polypoid lesions were analyzed retrospectively. All lesions had been totally removed by either endoscopic polypectomy or hot biopsy forceps. The histopathologic slides were re-evaluated by the same histopathologist.RESULTS: One-hundred and fifty gastric polypoid lesions were identified in 91 patients. There were 53 (58%) women and 38 (42%) men with a median age of 53 (range, 31 to 82) years. The most frequent presenting symptom was dyspepsia that was observed in 35 (38.5%) patients.Symptoms were mostly related to various associated gastric abnormalities such as chronic gastritis or H pylori infection rather than polypoid lesion itself. Polypoid lesions were commonly located in the antrum followed by cardia. Out of 150 lesions, 80 (53%) had the largest dimensions less than or equal to 5 mm and only 7 were pedunculated. The frequencies of hyperplastic polyps, foveolar hyperplasia, and fundic gland polyps were 46%, 18%, and 14% respectively.We also detected gastritis varioliformis in 12 specimens,lymphoid follicles in 9, 4 adenomatous polyps in 4, polypoid lesions with edematous mucosa in 4, inflammatory polyps in 3, and carcinoid tumor in 1. Adenomatous changes were observed within two hyperplastic polyps and low grade dysplasia in one adenoma. Histopathologic evaluation of the surrounding gastric mucosa demonstrated chronic gastritis in 72 (79%) patients and H pylori infection in 45 (49%).CONCLUSION: Hyperplastic polyps are the most frequently encountered subtype of gastric polypoid lesions. They are usually associated with chronic gastritis or H pylori gastritis. Contrary to the previous belief, they may harbour adenomatous changes or dysplastic foci.Therefore, endoscopic polypectomy seems as a safe and fast procedure for both diagnosis and treatment of gastric polypoid lesions at the same session. In addition,edematous mucosa may appear misleadingly as a polypoid lesion in some instances and it can be ruled out only by histopathologic examination. | Rasim Gencosmanoglu Ebru Sen-Oran Ozlem Kurtkaya-Yapicier Erol Avsar Aydin Sav Nurdan Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 19 | A biotechnological perspective on the application of iron oxide nanoparticles显示文摘在最近的十年,磁性的铁 nanoparticles (NP ) 在外部磁场下面由于象 superparamagnetism,高表面区域,大 surface-to-volume 比率,和容易的分离那样的性质吸引了许多注意。因此,磁性的氧化铁在众多的应用,包括的磁性的回声成像对比改进,织物修理,免疫分析,生物液体的 detoxification,药交货,过高热,和房间为使用有潜力分离。这评论提供一更新并且为 biotechnological 应用的合适的磁性的铁 NP 的制造和描述的综合焦点。在这些 NP 的进一步的发展的可能的观点和一些挑战也被讨论。 | Farnaz Assa Hoda Jafarizadeh-Malmiri Hossein Ajamein Navideh Anarjan Hamideh Vaghari Zahra Sayyar Aydin Berenjian | 2016 | Nano Research2016，9，8： | 8 |
| 20 | N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat显示文摘AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative stress.We aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P<0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，1： | 7 |
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