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| 1 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 2 | The prevalence of Helicobacter pylori in obese subjects显示文摘 | Erol Arslan Halil At?lgan ?rfan Yava?o?lu | 2009 | European Journal of Internal Medicine2009，，7： | 2 |
| 3 | Present standards for cervical cancer screening显示文摘 | O' Meare AT | 2002 | Curr Opin Oncol2002，14，5： | 1 |
| 4 | Microsurgical anato- my of the posterior spinal artery via a far-lateral transcon- dylar approach 显示文摘 | Seckin H Ates O Bauer AM | 2009 | J Neurosurgery Spine2009，10，3： | 1 |
| 5 | Second - line chem- otherapy with eapeeitabine (Xeloda) and doeetaxel ( Taxotere ) in previously treated, unresectable adenocarcinoma of pancreas : the fi- nal results of a phase II trial显示文摘 | Katopodis O Polyzos A Kentepozidis N et at | 2011 | Cancer Chemother Pharmaeol2011，67，2： | 1 |
| 6 | A comparison of three different intravitreal treatment modalities of macular edema due to branch retinal vein occlusion 显示文摘 | Cekic O Cakir M Yazici AT | 2010 | Curr Eye Res2010，35，： | 1 |
| 7 | Hydrosonographic as- sessment of the effects of 2 different suturing techniques on healing of the uterine scar after cesarean delivery 显示文摘 | Sevket O Ates S Molla T | 2014 | Int J Gynaecol Obstet2014，125，3： | 1 |
| 8 | Efficient oxidative folding of conotoxins and the radiation of venomous cone snails 显示文摘 | Bulaj G Buczek O Goodsell I el at | 2003 | Proe Nad Aead Sei USA2003，100，14： | 1 |
| 9 | Spinal muscular atrophy genotyping by gene dosage using multiple ligation-dependent probe amplification 显示文摘 | Scarciolla O Stuppia L De Angelis M V at al | 2006 | Neurogenetics2006，7，4： | 1 |
| 10 | Microalbuminuria in pregnancy as a predictor of preeclampsia and eclampsia显示文摘 | Salako BL Olayemi O Odukogbe AT | 2003 | West Afr J Med2003，22，4： | 1 |
| 11 | Myths about the treatment of addiction显示文摘 | O’Brien CP McLellan AT | 1996 | Lancet1996，347，8996： | 1 |
| 12 | QSulfl remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signling显示文摘 | Ai X Do AT Lozynska O | 2003 | J Cell Biol2003，162，2： | 1 |
| 13 | A functional variant at a prostate cancer predispositionlocus at 8q24 is associated with PVT1 expression显示文摘 | Meyer KB Maia AT O'Reilly M | 2011 | PLoS Genet2011，7，10： | 1 |
| 14 | Disinfection procedures: their efficacy and effect on dimensional accuracy and surface quality of an irreversible hydrocolloid impression material 显示文摘 | Rentzia A Coleman DC O'Donnell MJ et at | 2011 | J Dent2011，39，2： | 1 |
| 15 | Authentically leading groups: The role of collective psychological capital and trust 显示文摘 | Walmnbwa F O Luthans F Avey J B et at | 2011 | Journal of Organizational Behavior2011，32，1： | 1 |
| 16 | Evolutionarily eonselwed protein sequences of influenza A viruses, avian and human, as vaccine targets显示文摘 | Heiny AT Miotto O Srinivasan KN | 2007 | PLoS One2007，2，11： | 1 |
| 17 | The effect of dexmedetnmidine on arterial-cardiac baroreflex function assessed by spectral and transfer function analysis显示文摘 | Ehara T Ogawa Y Ka|o J et at | 2012 | J Anesth2012，26，4： | 1 |
| 18 | The value of transvaginal sonography in detecting endometrial pathologies in postmenopausal women with or without bleeding 显示文摘 | Ates S Sevket O Sudolmus S | 2014 | Minerva Gineeol2014，66，4： | 1 |
| 19 | Identification of deletions and duplications of the DMD gene in affected males and carrier females by multiple ligation probe amplification (MLPA) 显示文摘 | Gatta V Scarciolla O Gaspari A R at al | 2005 | Hum Genet2005，117，1： | 1 |
| 20 | Chemical fluxes and mass balances in a marine fish cage farm Carbon显示文摘 | HALL P O ANDERSON L G HOLBY O at al | 1990 | Mar Eco Prog Ser1990，61，： | 1 |
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