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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Sophorulipid bio- synthesis from a biodiesel co-product stream显示文摘 | Ashby R D Nunez A Solaiman D K Y | 2005 | J Am Oil Chem Soc2005，82，： | 1 |
| 3 | The medical management of ectopic pregnancy:a meta-analysis comparing 'single dose' and 'multidose' regimens显示文摘 | Barnhart KT Gosman G Ashby R | 2003 | Obstet Gynecol2003，101，4： | 1 |
| 4 | The medical management of ectopic pregnancy: a meta-analysis comparing 'single dose' and 'multidose' regimens显示文摘 | Barnhart KT Gosman G Ashby R | 2003 | Obstet Gynecol2003，101，4： | 1 |
| 5 | The effect of ambient illuminance on the development of deprivation myopia in chicks 显示文摘 | Ashby R Ohlendorf A Schaeffel F | 2009 | Invest Ophthalmol Vis Sci2009，50，： | 1 |
| 6 | The effect of ambient illuminance on the development of deprivation myopia in chicks显示文摘 | Ashby R Ohlendorf A Schaeffel F | | 0，，： | 1 |
| 7 | Alterations in ZENK and glueagon RNA transcript expression during increased ocular growth in chickens显示文摘 | Ashby R Kozulin P Megaw PL | 2010 | Mol Vis2010，16，： | 1 |
| 8 | LC/MS analysis arid lipase modification of the sophorolipids produced by Rhodotorula bogoriensis显示文摘 | Nunez A Ashby R Foglia T A | 2004 | Biotechnol Lett2004，26，： | 1 |
| 9 | Connectance of large dynamic (cybernetic) systems: critical values for stability显示文摘 | Ashby W R | 1970 | Nature1970，228，： | 1 |
| 10 | Diagrams for laser materials processing显示文摘 | Ion J C Shercliff H R Ashby M F | 1992 | Acta Metall Mater1992，40，7： | 1 |
| 11 | The mechanical properties of cellular solids显示文摘 | Ashby M F Medalist R F M | 1983 | Metallurgical Transactions A1983，14，9： | 1 |
| 12 | Self-esteem as a mediator between perfectionism and depression: A structural equations analysis 显示文摘 | Riee K G Ashby J S Slaney R | 1998 | Journal of Counseling Psychology1998，45，： | 1 |
| 13 | Effectiveness of ECT combined with risperidone against aggression in schizo- phrenia 显示文摘 | Shigehiro Hirose Charles R Ashby Ma-rko J | 2008 | The Journal of ECT2008，17，1： | 1 |
| 14 | Production of sophorohpids by Candida bombicola grown on soy molasses as substrate显示文摘 | Solaiman D K Y Ashby R D Nunez A | 2004 | Biotechnol Lett2004，26，： | 1 |
| 15 | Exposure to peroxisome proliferactors: reassessment of the potential carcinogenic hazard显示文摘 | Roberts R Moffat G Ashby J | 2001 | Environmental Health Perspectives2001，109，10： | 1 |
| 16 | A thermodynamic equilibrium model for calcium salt urolithiasis: clinical application显示文摘 | Gyory AZ | 1997 | Exp Nephrol1997，5，3： | 1 |
| 17 | Diffusion-accommodated flow and superplasticity显示文摘 | Ashby M F Verall R A | 1973 | Acta Metall1973，21，： | 1 |
| 18 | Head group-modified so-phorolipids:Synthesis of new cationic,zwitterionic,and anionic sur-factants显示文摘 | Zerkowski J Solaiman D.Y Ashby R | | 0，，： | 1 |
| 19 | On grain boundary sliding and diffusional creep 显示文摘 | Ashby M F | 1971 | Metall Trans1971，2，9： | 1 |
| 20 | A Process Model for Age Hardening of Aluminum Alloys-I The Model显示文摘 | SHERDIFF H R ASHBY M F | 1990 | Acta Metallurgy1990，38，10： | 1 |
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