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| 1 | Gastric adenocarcinoma of fundic gland type:Endoscopicand clinicopathological features显示文摘Gastric adenocarcinoma of fundic gland type(GA-FG) with chief cell differentiation was recently proposed as an extremely rare type of gastric adenocarcinoma. Here, we report 4 cases of GA-FG with chief cell differentiation. Endoscopic features included a submucosal tumor shape or a flat shape, whitish discoloration and dilated vessels on the surface. The tumors were located in the upper or middle third of the stomach. All cases were preoperatively diagnosed as GA-FG by biopsy, and endoscopic submucosal dissection was performed. Resected specimens revealed well-differentiated adenocarcinomas resembling chief cells. Tumor cells were diffusely positive for pepsinogen-Ⅰ, but partially positive for H+/K+-ATPase in scattered locations around the tumor margin. Despite the presence of minimal invasion of the carcinoma into the submucosal layer, which was observed in two cases, neither lymphatic nor venous invasion was detected in any of the cases. Finally, all cases showed less aggressive clinical behavior with low grade malignancy. | Gen Tohda Takeshi Osawa Yasuyuki Asada Masaki Dochin Shintarou Terahata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 26 |
| 2 | Acute kidney injury spectrum in patients with chronic liver disease:Where do we stand?显示文摘Acute kidney injury (AKI) is a common complication of liver cirrhosis and is of the utmost clinical and prognostic relevance. Patients with cirrhosis, especially decompensated cirrhosis, are more prone to develop AKI than those without cirrhosis. The hepatorenal syndrome type of AKI (HRS–AKI), a spectrum of disorders in prerenal chronic liver disease, and acute tubular necrosis (ATN) are the two most common causes of AKI in patients with chronic liver disease and cirrhosis. Differentiating these conditions is essential due to the differences in treatment. Prerenal AKI, a more benign disorder, responds well to plasma volume expansion, while ATN requires more specific renal support and is associated with substantial mortality. HRS–AKI is a facet of these two conditions, which are characterized by a dysregulation of the immune response. Recently, there has been progress in better defining this clinical entity, and studies have begun to address optimal care. The present review synopsizes the current diagnostic criteria, pathophysiology, and treatment modalities of HRS–AKI and as well as AKI in other chronic liver diseases (non-HRS–AKI) so that early recognition of HRS–AKI and the appropriate management can be established. | Wiwat Chancharoenthana Asada Leelahavanichkul | 2019 | World Journal of Gastroenterology2019，25，28： | 14 |
| 3 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 4 | Length-Sorted Semiconducting Carbon Nanotubes for High-Mobility Thin Film Transistors显示文摘我们为 solution-processable 为碳 nanotubes 的化学纯化开发了一个过程有高活动性的薄电影的晶体管(TFT ) 。简单落下涂层制作的净化的碳 nanotubes 的电影象 164 cm2V1s1, 0.78 Sm1 的规范的跨导,和开/关电流一样高显示出搬运人活动性 106 的比率。如此的高效要求测微计长、高度净化的半导体的围单人赛的碳 nanotubes (SWCNT ) 的暂停的准备。我们的纯化过程包括长度并且用与表面活化剂的混合物再循环胶化过滤的 SWCNT 的电子类型的选择套住。结果提供一个重要里程碑向与 roll-to-roll 和墨水喷气设备制造打印了高速度、大区域的电子学。 | Yasumitsu Miyata Kazunari Shiozawa Yuki Asada Yutaka Ohno Ryo Kitaura Takashi Mizutani Hisanori Shinohara | 2011 | Nano Research2011，4，10： | 5 |
| 5 | Comparison of early pre-cutting vs standard technique for biliary cannulation in endoscopic retrograde cholangiopancreatography: A personal experience显示文摘AIM: To compare the results and complications of early pre-cutting technique with standard technique. METHODS: From January 2003 to December 2004, a total of 416 consecutive therapeutic biliary ERCP procedures were performed by one endoscopist (T.A.). Data were retrospectively collected according to procedure indication and results. Of these, 293 procedures (70.4%) were done with standard technique (group A) and 123 procedures (29.6%) with early pre-cutting technique in case of difficult cannulation (group B). The results and complications of ERCP were compared. RESULTS: Success rate of first attempt cannulation was 98.0% in group A and 87.8% in group B. The overall incidence of post-ERCP pancreatitis, hemorrhage, perforation and cholangitis was 0%, 0.2%, 0.5% and 0.5%, respectively. Morbidity rate was not significantly different. No procedure-related mortality was occurred. CONCLUSION: For an experienced hand, the early pre-cutting technique for biliary cannulation is safe and effective as standard technique. | Kannikar Laohavichitra Thawatchai Akaraviputh Asada Methasate Somchai Leelakusolvong Udom Kachintorn | 2007 | World Journal of Gastroenterology2007，13，27： | 4 |
| 6 | Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication显示文摘AIM To investigate the role of Delta-like ligand 4(DLL4) on tumour growth in hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC) in vivo.METHODS We suppressed DLL4 expression in an HBV expressing HCC cell line, HepG2.2.15 and analysed the growth ability of cells as subcutaneous tumours in nude mice. The expression of tumour angiogenesis regulators, VEGF-A and VEGF-R2 in tumour xenografts were examined by western blotting. The tumour proliferation and neovasculature were examined by immunohistochemistry. The viral replication and viral protein expression were measured by quantitative PCR and western blotting, respectively.RESULTS Eighteen days after implantation, tumour volume in mice implanted with sh DLL4 HepG2.2.15 was significantly smaller than in mice implanted with control HepG2.2.15(P < 0.0001). The levels of angiogenesis regulators, VEGF-A and VEGF-R2 were significantly decreased in implanted tumours with suppressed DLL4 compared with the control group(P < 0.001 and P < 0.05, respectively). Furthermore, the suppression of DLL4 expression in tumour cells reduced cell proliferation and the formation of new blood vessels in tumours. Unexpectedly, increased viral replication was observed after suppression of DLL4 in the tumours.CONCLUSION This study demonstrates that DLL4 is important in regulating the tumour growth of HBV-associated HCC as well as the neovascularization and suppression of HBV replication. | Areerat Kunanopparat Jiraphorn Issara-Amphorn Asada Leelahavanichkul Anapat Sanpavat Suthiluk Patumraj Pisit Tangkijvanich Tanapat Palaga Nattiya Hirankarn | 2018 | World Journal of Gastroenterology2018，24，34： | 3 |
| 7 | Role of endoscopy in caustic injury of the esophagus显示文摘Caustic injury of the esophagus is a problematic condition challenging endoscopists worldwide. Althoughthe caustic agents and motives are different among countries and age groups, endoscopy still plays an invaluable role in diagnosis and treatment. Endoscopy can determine the severity of caustic ingestion which is of great importance in choosing appropriate treatment. However, some aspects of endoscopy in diagnosis of caustic injury remain controversial. Whether or not all patients need endoscopy, when to perform endoscopy and how to assess the severity are just some examples of these controversies. Due to lack of randomized controlled trials, many findings and suggestions are inconclusive. Computerized tomography scan of the chest and abdomen gains popularity in assessing the severity of caustic injury and avoiding unnecessary surgery. If esophageal stricture eventually develops, endoscopic dilatation is a mainstay. Maneuvers such as steroid injection and esophageal stent may be used in a refractory stricture. Nevertheless, some patients have to undergo surgery in spite of vigorous attempts with esophageal dilatation. To date, caustic injury remains a difficult situation. This article reviews all aspects of caustic injury of the esophagus focusing on endoscopic role. Pre-endoscopic management, endoscopy and its technique in acute and late phase of caustic injury including the endoscopic management of refractory stricture, and the treatment outcomes following each endoscopic intervention are thoroughly discussed. Finally, the role of endoscopy in the long term follow-up of patients with esophageal caustic injury is addressed. | Asada Methasate Varut Lohsiriwat | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 3 |
| 8 | Hydrocarbon-Degrading Bacteria and Paraffin from Polluted Seashores 9 Years after the Nakhodka Oil Spill in the Sea of Japan显示文摘石油烃的污染,特别地油喷洒,在过去和最近的十年吸引了许多注意。油喷洒影响自然微生物引起的社区,并且物理并且影响地点的化学性质。由微生物的烃的简历降级是油喷洒被从污染地点消除的主要方法之一。一如此的喷洒是俄语的油轮的在 1 月 2,1997 日流出了重油进日本的海的临日本海之西伯利亚的不冻港。临日本海之西伯利亚的不冻港油喷洒的影响导致了一粘滞对岸和影响自然生态系统犯规的粘的液体。这篇论文从临日本海之西伯利亚的不冻港油描述捱过的降级 ofhydrocarbon 细菌(类 Pseudomonas ) 和使结晶的有机化合物在九年以后的弄脏喷洒的海岸。临日本海之西伯利亚的不冻港油变硬并且形成了在 9 年简历补习以后与石墨和方解石联合由 XRD 分析(0.422, 0.377,和 0.250 nm d 间距) 出现的水晶的石蜡蜡的外壳。油外壳的厌氧的反向的方面包含了打的细菌与岩盐联系了的众多的球菌。在油外壳中的发现降级 ofhydrocarbon 细菌和石蜡蜡可以有重要效果在捱过油在 9 年的简历补习期间流出的临日本海之西伯利亚的不冻港的过程。 | Kazue TAZAKI Hiroaki WATANABE Siti Khodijah CHAERUN Koichi SHIRAKI Ryuji ASADA | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 3 |
| 9 | Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiency显示文摘有风湿性关节炎(RA ) 的 29 年的历史的一个 56 岁的女人进入医院,抱怨高发烧,腹的疼痛和严重流血腹泻。结肠镜检查与从直肠延长到远侧的横向的冒号的自发的流血、弥漫的侵蚀和溃疡揭示了脆、水肿的粘膜。直肠的活体检视的组织病理学说的调查结果与 ulcerative (UC ) 兼容。作为有严重活跃左边的 UC 被诊断,她成功地被对待,静脉内的甲基氢化尼松由氢化尼松和 leukocytapheresis 列在后面。实验室测试揭示了低浆液和口水 IgA 层次,它可能在 UC 的发展起一个作用。到我们的知识,这是发生在 RA 的功课期间的 UC 的第一个盒子,由选择 IgA 缺乏伴随了。 | Yuki Asada Hajime Isomoto Saburo Shikuwa Chun Yang Wen Eiichiro Fukuda Masaru Miyazato, Kenta Okamoto Takashi Nakamura Hitoshi Nishiyama Yohei Mizuta Kiyoshi Migita Masahiro Ito Shigeru Kohno | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 10 | Modeling the effects of cooling rate, hydrogen content, grain refiner and modifier on microporosity formation in Al A356 alloys 显示文摘 | Conley J G Huang J L Asada J | 2000 | Material Science and Engineering A2000，285，12： | 2 |
| 11 | Wafer yield prediction by the Mahalanobis-Taguchi system 显示文摘 | Masashi Asada | 2001 | IEEE International Workshop on Statistical Methodology2001，6，： | 2 |
| 12 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 13 | Inflammatory pseudotumor of the liver and peripheral eosinophilia in autoimmune pancreatitis显示文摘AIM: Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion, the etiology of which remains obscure.It is not associated with any particular diseases apart from phlebitis and Crohn's disease.METHODS: A middle-aged male with hepatic IPT and peripheral eosinophilia associated with autoimmune pancreatitis (AIP) was selected for this study and review of literature.RESULTS: A 59-year-old male was admitted with obstructive jaundice, marked eosinophilia (1 343/mm3)and hypergammaglobulinemia (4 145 mg/dL). Imaging techniques revealed dilatation of the intrahepatic bile duct,stenosis of the common bile duct with diffuse wall thickening, gallbladder wall thickening, irregular narrowing of the pancreatic duct, and swelling of the pancreatic parenchyma. Multiple liver masses were also demonstrated and diagnosed as IPT by biopsy specimens. Six months later, the abnormal features of the biliary tree remarkably improved by the oral administration of prednisolone, and the liver masses disappeared. The swelling of the pancreatic head also improved. The peripheral eosinophil count normalized. IPT associated with AIP, as we know,has not been reported in the literature. The clinical features of the present case mimicked those of pancreatic cancer with liver metastasis. This case deserves to be documented to prevent misdiagnosis of similar cases. | Naoki Sasahira Takao Kawabe Akira Nakamura Kenji Shimura Haruhisa Shimura Ei Itobayashi Manabu Asada Yasushi Shiratori Masao Omata | 2005 | World Journal of Gastroenterology2005，11，6： | 2 |
| 14 | Endoscopic resection of large colorectal polyps using a clipping method显示文摘 | Dr. Yoshiro Iida M.D. Shoji Miura M.D. Yoshinori Munemoto M.D. Yoshio Kasahara M.D. Yasuyuki Asada M.D. Daishu Toya M.D. Masakiyo Fujisawa M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 2 |
| 15 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons显示文摘 | Kozi Asada | 1999 | Annual Review of Plant Physiology and Plant Molecular Biology1999，，： | 2 |
| 16 | Endoscopic management of biliary strictures after duct-to-duct biliary reconstruction in right-lobe living-donor liver transplantation显示文摘 | Hiroshi Hisatsune Shujiro Yazumi Hiroto Egawa Masanori Asada Kazunori Hasegawa Yuzo Kodama Kazuichi Okazaki Kyo Itoh Hiroshi Takakuwa Koichi Tanaka Tsutomu Chiba | 2003 | Transplantation2003，，5： | 2 |
| 17 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons显示文摘 | Kozi Asada | 1999 | Annual Review of Plant Physiology and Plant Molecular Biology1999，，： | 2 |
| 18 | Hydrogen peroxide is scavenged by ascorbate-specific per-oxidase in spinach chloroplasts显示文摘 | Y Nakaho K Asada | 1981 | Plant Cell Physiol1981，22，5： | 1 |
| 19 | Assessment of p-glycoprotein expression in patients with malignant bone and soft-tissue tumours using technetium-99m-MIBI scintigraphy 显示文摘 | Sumiya SP Asada N | 1998 | J Nucl Med1998，39，7： | 1 |
| 20 | Structural comparison of three types of staphylococcal cassette chromosome m ec integrated in the chromosome in methicillin resistant Staphylococcus aureus 显示文摘 | Ito T Katayama Y Asada K | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
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