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| 1 | Balanced propofol sedation administered by nonanesthesiologists:The first Italian experience显示文摘AIM:To assess the efficacy and safety of a balanced approach using midazolam in combination with propofol,administered by nonanesthesiologists,in a large series of diagnostic colonoscopies.METHODS:Consecutive patients undergoing diagnostic colonoscopy were sedated with a single dose of midazolam(0.05 mg/kg)and lowdose propofol(starter bolus of 0.5 mg/kg and repeated boluses of 10 to 20 mg).Induction time and deepest level of sedation,adverse and serious adverse events,as well as recovery times,were prospectively assessed.Cecal intubation and adenoma detection rates were also collected.RESULTS:Overall,1593 eligible patients were included.The median dose of propofol administered was 70 mg(range:40120 mg),and the median dose of midazolam was 2.3 mg(range:24 mg).Median induction time of sedation was 3 min(range:14 min),and median recovery time was 23 min(range:1040 min).A moderate level of sedation was achieved in 1561(98%) patients,whilst a deep sedation occurred in 32(2%) cases.Transient oxygen desaturation requiring further oxygen supplementation occurred in 8(0.46%;95% CI:0.2%0.8%)patients.No serious adverse event was observed.Cecal intubation and adenoma detection rates were 93.5%and 23.4%(27.8%for male and 18.5%for female,subjects),respectively.CONCLUSION:A balanced sedation protocol provided a minimalization of the dose of propofol needed to target a moderate sedation for colonoscopy,resulting in a high safety profile for nonanesthesiologist propofol sedation. | Alessandro Repici Nico Pagano Cesare Hassan Alessandra Carlino Giacomo Rando Giuseppe Strangio Fabio Romeo Angelo Zullo Elisa Ferrara Eva Vitetta Daniel de Paula Pessoa Ferreira Silvio Danese Massimo Arosio Alberto Malesci | 2011 | World Journal of Gastroenterology2011，17，33： | 2 |
| 2 | 亚基特异性铁蛋白单克隆抗体对人肝癌与肝脏铁蛋白生化免疫性质分显示文摘1975年,Alpert首次报道肝癌组织铁蛋白等电聚焦电泳位置与正常肝有所不同,其等电点略偏酸性,而与人胎肝铁蛋白相似,称之癌胚铁蛋白(Carcino-fetal ferritin)。最近我们与意大利米兰大学生物医学技术部合作,以重组的H和L铁蛋白亚基及其相应的单克隆抗体与从人肝癌和肝脏中提取纯化的铁蛋白及其相应的多克隆抗体进行生化免疫性质比较,结果报道如下。 | 范桢 汤钊猷 周信达 Paolo Arosio | 1991 | 肿瘤1991，11，1： | 2 |
| 3 | Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride 显示文摘 | Arosio B Gagliano N Fusaro LM | 2000 | Pharmacol Toxicol2000，87，5： | 1 |
| 4 | Effectiveness of long-term rosiglitazone administration in patients with Cushing's disease 显示文摘 | Cannavo S Arosio M Almoto B | 2005 | Clin Endocrinol2005，63，1： | 1 |
| 5 | Influence of solfon- ated melamine formaldehyde condensate on the quality of building blocks production by extrusion of cement-clay pastes显示文摘 | Arosio F Castoldi L Ferlazzo N | 2007 | Applied Clay Science2007，35，12： | 1 |
| 6 | Energy saving through the sun:analysis of visual comfort and energy consumption in office space显示文摘 | TAGLIABUE L C BUZZETTI M AROSIO B | 2012 | Energy Proce- dia2012，，30： | 1 |
| 7 | Improved synthesis of both enantiomers of trans-cyclohex-4-ene-1,2-dicarboxylic acid显示文摘 | Bernardi A Arosio D Dellavecchia D | 1999 | Tetrahedron Asymmetry1999，10，： | 1 |
| 8 | Importance of acute Mycoplasma pneumoniae and Chiamydia pneumoniae infections in children with wheezing显示文摘 | Esposito S Blasi F Arosio C | 2000 | Eur Respir J2000，16，6： | 1 |
| 9 | New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity 显示文摘 | Recalcati S Invemizzi P Arosio P | 2008 | Journal ofdutoimmunity2008，30，12： | 1 |
| 10 | Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing显示文摘 | Esposito S Blasi F Arosio C | 2000 | Eur Respir J2000，16，6： | 1 |
| 11 | Age-dependent expressionof fibrosis-related genes and collagen deposition in the rat myocardium显示文摘 | Luvara G Arosio B | 1998 | Mech Ageing Dev1998，101，12： | 1 |
| 12 | Aloe - emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride 显示文摘 | Gagliano N Fusaro LMP | 2000 | Pharmacol Toxicol2000，87，5： | 1 |
| 13 | Clinical biochemical and morphological correlates in patients bearing growth hormone--secreting pituitary tumora with or without constituitively active adenylyl cyclase显示文摘 | Spada A Arosio M Bochicchio D | 1990 | J Clin Endocrinol Metab1990，71，： | 1 |
| 14 | Cytosolic and mitochondrial ferritins in the reg- ulation of cellular iron homeostasis and oxidative damage 显示文摘 | Arosio P Levi S | 2010 | Biochim Biophys Acth2010，1800，8： | 1 |
| 15 | Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis 显示文摘 | VALENTI L PULIXI E A AROSIO P | 2007 | Haematologica2007，92，8： | 1 |
| 16 | The fenitins: molecular properties, iron storage function and cellular regulation 显示文摘 | HARRISON P M AROSIO P | 1996 | Biochimiea et Biophysica Acta1996，1275，3： | 1 |
| 17 | Cytokine polymorphisms in the pathophysiology of mood disorders显示文摘 | Clerici M Arosio B Mundo E | 2009 | CNS Spectr2009，14，8： | 1 |
| 18 | The ferritins: molecular properties, iron storage function and cellular regulation显示文摘 | HARRISON P M AROSIO P | 1996 | Biochimica et Biophysica Acta-Bioenergetics1996，1275，3： | 1 |
| 19 | Ferritin: Molecular properties, iron storage function and cellular regulation显示文摘 | HARRISON P M AROSIO P | 1996 | Biochim Biophys Acta1996，1257，： | 1 |
| 20 | Effects of exercise on platelet aggregation in vascular diseases显示文摘 | Arosio E March S Prior M | 1998 | Minerva Cardioangiol1998，46，9： | 1 |
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