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1宏观经济水资源规划多目标决策分析方法研究及应用显示文摘本文是将区域水资源规划纳入到宏观经济/环境系统中,应用多目标技术进行整体研究,使决策者可通过宏观经济水资源规划多目标决策分析模型的操作和运行,看到在不同策略下区域宏观经济、环境等目标与水资源规划关系的全貌.在该方法研究中,作者完成了这一方法的软件编制和开发工作,实现了决策分析过程的计算机化。翁文斌 蔡喜明 史慧斌 王浩 米柯森(ARI M.MICHELSEN) 巴格(JONA BARGUR) 1995水利学报1995,27,2:73
2电动汽车示范运营的政策与商业模式创新:全球经验及中国实践显示文摘发展电动汽车作为应对能源危机和环境污染的有效手段,受到全球各国的关注。本文以纽约、洛杉矶、波特兰、神奈川、鹿特丹、阿姆斯特丹、巴黎、巴塞罗那、柏林、汉堡、赫尔辛基、斯德哥尔摩、东北英格兰和北布拉邦特14个全球电动汽车产业发展较为快速的城市和地区为研究对象,在分析14个城市和地区的人口、面积、汽车保有量、电动汽车及充电设施数量等基本数据的基础上,重点从产业发展战略和投资、相关补贴和税收政策,法规和标准,以及是否设立专门机构4个方面对14个城市和地区促进电动汽车产业发展的政策进行剖析,并进一步按照电动汽车运营创新、电动汽车充电设施创新、电动汽车项目整合创新以及公众意识培育创新4个方面对14个城市和地区示范项目中特色鲜明的商业模式创新活动进行研究。最后通过对比中国新能源汽车推广应用城市的基础指标、相关政策和相关创新活动,本文得出,中国电动汽车产业发展需要在政府政策、商业模式创新、合作伙伴以及公众意识提升几个方面加大投入,从而加快中国电动汽车产业发展。刘颖琦 王静宇 Ari Kokko 2014中国软科学2014,,12:43
3基于专利信息的中国新能源汽车产业技术创新研究显示文摘[目的/意义]中国新能源汽车产业的发展受到了政府和企业的共同关注,通过专利信息研究该产业技术创新的现状和趋势具有重要意义。[方法/过程]从专利数据出发,从年代分布、申请人分布、专利技术领域分布的视角出发剖析了中国新能源汽车产业技术创新现状,进而对中国新能源汽车产业链和专利数据进行了关联分析。[结果/结论]研究清晰地反映了中国新能源汽车产业技术创新的全貌,并为未来中国新能源汽车的技术创新提供了思路。王静宇 刘颖琦 Ari Kokko 2016情报杂志2016,35,1:42
4产业联盟中知识转移、技术创新对中国新能源汽车产业发展的影响显示文摘本文应用Citespace软件对产业联盟的文献计量分析表明,国内外研究在知识转移、技术创新、联盟管理等方面成果丰富。但中国新能源汽车产业联盟的理论和实践中,这几方面仅处于起步阶段。因此,未来对中国新能源汽车产业联盟的研究需在技术创新、知识转移、管理体系建立、标准化等领域加大力度,以更好地促进中国新能源汽车产业发展。刘颖琦 王静宇 Kokko Ari 2016中国软科学2016,,5:26
5Plasmonic nanostructure design and characterization via Deep Learning显示文摘Nanophotonics,the field that merges photonics and nanotechnology,has in recent years revolutionized the field of optics by enabling the manipulation of light–matter interactions with subwavelength structures.However,despite the many advances in this field,the design,fabrication and characterization has remained widely an iterative process in which the designer guesses a structure and solves the Maxwell’s equations for it.In contrast,the inverse problem,i.e.,obtaining a geometry for a desired electromagnetic response,remains a challenging and time-consuming task within the boundaries of very specific assumptions.Here,we experimentally demonstrate that a novel Deep Neural Network trained with thousands of synthetic experiments is not only able to retrieve subwavelength dimensions from solely farfield measurements but is also capable of directly addressing the inverse problem.Our approach allows the rapid design and characterization of metasurface-based optical elements as well as optimal nanostructures for targeted chemicals and biomolecules,which are critical for sensing,imaging and integrated spectroscopy applications.Itzik Malkiel Michael Mrejen Achiya Nagler Uri Arieli Lior Wolf Haim Suchowski 2018Light(Science & Applications)2018,7,1:25
6Thymoma and autoimmunity显示文摘The thymus is a central lymphatic organ that is responsible for many immunological functions,including the production of mature,functional T cells and the induction of self-tolerance.Benign or malignant tumors may originate from the thymus gland,with thymoma being the most common and accounting for 50% of anterior mediastinal tumors.Malignancies linked to thymoma include the loss of self-tolerance and the presence of autoimmunity.In this review,we compiled the current scientific evidence detailing the various interactions between thymoma and autoimmune diseases,including myasthenia gravis,systemic lupus erythematosus,inappropriate antidiuretic hormone secretion,pure red cell aplasia,pernicious anemia,pemphigus and autoimmune thyroid diseases.In recent years,several mechanisms have been proposed to explain these interactions.Most are based on the assumption that the‘sick’thymus,like the‘normal’thymus,can generate mature T cells;however,the T cells generated by the sick thymus are impaired and thus may exert cellular autoreactivity.Here,we present several theories that may shed light on the loss of self-tolerance associated with this epithelial tumor of the thymus.Shahar Shelly Nancy Agmon-Levin Arie Altman Yehuda Shoenfeld 2011Cellular & Molecular Immunology2011,8,3:19
7Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury显示文摘瞄准:在损害(SCI ) 在老鼠建模的试验性的脊髓调查 resveratrol 的 neuroprotective 效果。方法:男 Wistar 白鼠称 200-250 g 被使随机化进六个组。重量落下损伤为 SCI 被执行。组 1 独自经历了椎板切除术。组 2 经历了 SCI 跟随的椎板切除术。3, 4, 5,和 6 经历了的组 SCI 跟随并且收到了 resveratrol (100 mg/kg ) 的椎板切除术,甲基氢化尼松(MP )(30 mg/kg ) ,加 MP (30 mg/kg ) 的 resveratrol (100 mg/kg ) ,和乙醇(2%) 分别地。老鼠为生物化学的分析被划分成二亚群(在外科以后在 24 点杀死了 h ) 并且为 neurobehavioral 和组织病理学说的评估(在外科以后在 6 点杀死了星期) 。在外科以后的 Posttraumatic 神经病学的恢复每周被记录。结果:3 和 5 揭示了的组显著地比组织 4 降低 malon-dialdehyde,氮的氧化物,黄嘌呤氧化酶,和更高的谷胱甘肽层次(P<0.05 ) 。神经病学的恢复率显著地更好在比组织 4 组织 3 和 5 (P<0.05 ) 。当针的损伤尺寸比率被比较时,在治疗组之间没有有效差量。结论:Resveratrol 处理比 MP 处理在损伤的尖锐阶段揭示了更好生物化学的恢复。尽管 resveratrol 和联合处理比 MP 处理揭示了更好的 neurobehavioral 恢复;resveratrol, MP,和联合处理形式在实验的最后的阶段在一样的水平改进了组织病理学说的恢复。当每药有行动的不同抗氧化的机制,与 MP 包含 resveratrol 和不同剂量联合的不同剂量的未来研究能答应更好的结果。Ozkan ARIES Suleyman CAYLI Eyup ALTINOZ Iclal GURSES Neslihan YUCEL Ayhan KOCAK Saim YOLOGLU Yusuf TURKOZ 2006Acta Pharmacologica Sinica2006,27,10:18
8战略性新兴产业商业模式创新的系统理论框架显示文摘战略性新兴产业发展过程中,在技术创新与进步备受重视的同时,商业模式创新是产业化的重要前提也逐渐成为共识。文章结合战略性新兴产业的发展特点和趋势,基于战略三角理论"制度条件、产业结构、资源与能力"的视角,构建了涵盖"触发—演变—评价"动态环节的"战略性新兴产业商业模式创新的系统研究框架"。在此基础上,文章以全球新能源汽车产业发展最为迅速的中国市场为案例,应用理论框架对新能源汽车产业商业模式创新进行了剖析。研究表明:战略性新兴产业商业模式创新的理论分析框架对于深入研究产业商业模式的动态和系统演变具有重要的理论价值和意义。李苏秀 刘颖琦 张力 Ari Kokko 2018科学学研究2018,36,6:16
9世界腹腔间隙学会腹内高压和腹腔间隙综合征2013版专家共识与诊疗指南显示文摘随着人们对腹内压(intra-abdominal pressure,IAP)的重视,大量研究开始关注腹内高压(intraabdominal hypertension,IAH)和腹腔间隙综合征(abdominal compartment syndrome,ACS).世界腹腔间隙学会(The abdominal compartment society,WSACS)先后在2006年提出了IAH和ACS的专家共识,2007年发表了诊疗指南,2009年明确了疾病相关研究的推荐方向.2013年WSACS发布了新的IAH和ACS专家共识与诊疗指南.该指南由多学科专家共同参与制定,大部分是外科专家和重症监护专家.专家们首先明确24个临床医师关心的IAH和ACS问题,随后进行了系统有序的文献整理.Andrew W.Kirkpatrick Derek J.Roberts Jan De Waele Roman Jaeschke Manu L.N.G.Malbrain Bart De Keulenaer Juan Duchesne Martin Bjorc Ari Leppaniemi 2015中华外科杂志2015,53,3:15
10中国新能源汽车产业不同阶段商业模式创新特点及案例研究显示文摘本文划分了中国新能源汽车产业发展阶段,并梳理不同阶段的商业模式创新活动;然后基于所构建的'中国新能源汽车商业模式形态学矩阵分析框架',探讨了不同产业阶段中的商业模式创新案例,包括深圳普天模式、合肥定向购买模式、杭州微公交模式和北京车纷享模式这四个代表了不同产业阶段不同形式的商业模式创新典型案例。研究表明,商业模式创新离不开产业发展阶段和产业环境的特点,同时更多利益相关者及创新活动的加入将为中国未来新能源汽车商业模式及创新提供借鉴。李苏秀 刘颖琦 Ari Kokko 2017经济问题探索2017,,8:14
11多层次视角下的商业模式创新路径--中国新能源汽车产业实证显示文摘为了更好地理解商业模式创新路径,本文引入社会技术系统转型理论中的重要分析框架多层次分析视角,在大环境、体制和技术利基三层框架的基础上增加商业模式层,构建多层次视角下的商业模式创新路径模型,分析五种典型商业模式创新路径。在此基础上,以中国新能源汽车产业为例,对五种路径进行案例研究,并对商业模式创新路径和影响因素的演化规律进行剖析。研究表明:①通过大环境、体制层、技术利基的多层次作用,商业模式存在拓展型、复制型、整合型、模仿型和替代型五条创新路径;②从五条路径的发展趋势来看,商业模式创新对体制层的依赖性正在减弱,技术利基对商业模式创新的驱动作用越来越大,新技术变革或将促使商业模式发生颠覆式创新;③商业模式创新影响因素的演进特征是,大环境是不确定的变化要素、体制层采取共生—竞争—共生的动态策略、技术利基呈现未成熟—成熟—未成熟的螺旋上升演进态势。张力 刘颖琦 张雷 Ari Kokko 2021中国科技论坛2021,,2:14
12变网格间距速度层析成像方法显示文摘变网格间距速度层析成像,是指反演网格模型中采用不同的网格间距反演地下地层的速度分布,它可以在观测数据较少的情况下,提高浅部地层速度反演的分辨率和深层速度反演的精度。变网格间距与规则网格间距速度层析成像方法类似,但有两个最主要的不同之处:射线正演网格单元的射线段被划分到相应的较大反演网格单元中,平滑约束方程在变网格间距界面的上一平面和下一平面的网格处需要做出适当的修改。文中首先采用变网格方法对二维和三维检测板模型进行恢复测试,反演结果对大、小异常体的刻画效果均比规则网格方法好;然后,采用变网格方法对实际资料进行走时反演,反演结果对两个低速异常区的刻画比规则网格方法的效果好。因此,变网格方法反演的速度剖面分辨率较高,尤其对浅部地层的速度成像效果具有较大的改善作用;另外,在观测数据较少的情况下,通过调整不同网格的数量比例,变网格反演方法还可以克服层析成像过程中解的欠定问题。黄光南 刘洋 Ari Tryggvason 胡光义 范廷恩 董建华 2013石油地球物理勘探2013,48,3:13
13Cytopathologic diagnosis of fine needle aspiration biopsies of thyroid nodules显示文摘Fine-needle aspiration(FNA) cytology is an important diagnostic tool in patients with thyroid lesions.Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules.However cases with indeterminate cytological findings still remain a matter of debate.In this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules.A review of the English literature was conducted,and data were analyzed and summarized and integrated from the authors' perspective.The main purpose of thyroid FNA is to identify patients with higher risk for malignancy,and to prevent unnecessary surgeries for benign conditions.The Bethesda System for Reporting Thyroid Cytopathology is the most widely used system for the diagnosis of thyroid FNA specimens.This system also contains guidelines for the diagnosis and treatment of indeterminate or suspicious for malignancy cases.In conclusion,patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%.Evangelos P Misiakos Niki Margari Christos Meristoudis Nickolas Machairas Dimitrios Schizas Konstantinos Petropoulos Aris Spathis Petros Karakitsos Anastasios Machairas 2016World Journal of Clinical Cases2016,4,2:12
14社会网络视角下的产业联盟技术创新——中国新能源汽车产业联盟的实证显示文摘文章以网络收益划分为切入点,构建了社会网络视角下产业联盟技术创新的分析框架和收益模型;应用中国新能源汽车产业联盟的相关数据对模型进行了实证研究;对结构嵌入性和关系嵌入性、强关系和弱关系在联盟技术创新过程中的作用进行了进一步讨论。研究表明:在技术创新过程中关系嵌入性为新能源汽车产业联盟带来的收益更多,其中弱关系为联盟成员带来了更多的一般知识通路、新思想以及供销渠道,因而一直对联盟的技术创新产生正向影响;强关系在联盟技术创新初期提供了大量的冗余知识,浪费了大量的维系成本,因此这一阶段强关系带来的净收益是负的,然而随着技术创新的不断深入,合作变得越来越重要,强关系带来的净收益变为正向的,并呈现出逐年上升的趋势。王静宇 刘颖琦 Ari Kokko 2017中国科技论坛2017,,5:11
15More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted.Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius 2019General Psychiatry2019,32,4:11
16“十城千辆”示范工程政策与效果比较研究显示文摘文章以中国自'十城千辆'示范工程开展以来发展较为成功的几个重要城市:北京、上海、深圳等为研究对象,对比几个典型城市新能源公交车的现行政策,从技术和实际运营数量来研究和分析政策效果,在此基础上,讨论了油价对新能源汽车产业发展的影响以及政策的有效性问题。研究表明,政府的政策对中国新能源公交车的发展起到了重要作用并且汽油价格的上升也将为新能源公交车提供更广阔的空间,但政府政策在明确技术方向、探索商业模式以及政策的明晰程度等方面还有较大的提升空间。王静宇 刘颖琦 Kokko Ari 2012科学决策2012,,12:11
17Immunoglobulin G4-related kidney diseases: An updated review显示文摘This review will encompass definition, pathogenesis, renal clinical manifestations and treatment of immunoglobulin G4-related diseases( IgG4-RDs). IgG4-RD is a recently recognized clinical entity that often involves multiple organs and is characterized by high levels of serum immunoglobulins G4, dense infiltration of IgG4+ cells and storiform fibrosis. Cellular immunity, particularly T-cell mediated immunity, has been implicated in the pathogenesis of IgG4-RDs. The most frequent renal manifestations of IgG4-RD are IgG4-related tubulointerstitial nephritis, membranous glomerulopathy and obstructive nephropathy secondary to urinary tract obstruction due to IgG4-related retroperitoneal fibrosis. IgG4-RD diagnosis should be based on specific histopathological findings, confirmed by tissue immunostaining, typical radiological findings and an appropriate clinical context. The first line treatment is the steroids with two warnings: Steroid resistance and relapse after discontinuation. In the case of steroid resistance, B cell depleting agents as rituximab represent the secondline treatment. In the case of relapse after discontinuation, steroid treatment may be associated with steroid sparing agents. Since the disease has been only recently identified, more prospective, long-term studies are needed to an improved understanding and a more correct and safe treatment.Maurizio Salvadori Aris Tsalouchos 2018World Journal of Nephrology2018,7,1:10
18外国直接投资激励经济学显示文摘Blomstrm Ari Kokko 赵学尽 黄克臣 2005经济资料译丛2005,,2:9
19Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice.Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir 2018World Journal of Gastroenterology2018,24,45:9
20桥接组合式内固定系统与锁定钢板治疗锁骨中段骨折的Meta分析显示文摘目的:目前临床上治疗锁骨中段骨折最常用的是锁定钢板,桥接组合式内固定系统是一种新型内固定器械,其用于治疗锁骨中段骨折时间并不长,但是国内许多学者已经发表了很多篇临床研究来比较两者的疗效,但是尚无统一意见。文章对桥接组合式内固定系统和锁定钢板治疗锁骨中段骨折的临床疗效进行Meta分析。方法:应用计算机检索PubMed、Medline、The Cochrane Library、迈特思创FMRS外文医学信息平台、OVID医学期刊全文数据库、维普、中国知网和万方数字化期刊平台,收集2010年1月至2020年4月发表的对比桥接组合式内固定系统和锁定钢板治疗锁骨中段骨折的临床对照试验。根据纳入标准和排除标准筛选文献,采用Jadad量表和MINORS评分表进行文献质量评估,对纳入的研究进行质量评价以及数据提取,选择手术时间、术中出血量、骨折愈合时间、并发症及术后1年肩关节功能评分作为Meta分析的评价指标,利用Cochrane协作网提供的RevMan 5.2软件对纳入研究结果进行Meta分析。结果:①文章纳入了中文及外文文献共9篇,其中随机对照试验3篇,非随机对照试验6篇,共计613例锁骨中段骨折的患者,其中桥接组280例,钢板组333例;②通过Meta分析可得:两种方法在术后肩关节功能(MD=3.23,95%CI:0.13-6.33,P=0.04)方面差异无显著性意义,但桥接组在手术时间(MD=-4.62,95%CI:-9.08至-0.16,P=0.04)、术中出血量(MD=-15.29,95%CI:-15.81至-14.47,P<0.00001)、骨折愈合时间(MD=-2.88,95%CI:-3.10至-2.65,P<0.00001)和总体并发症(OR=0.21,95%CI:0.09-0.48,P=0.0002)方面均优于钢板组。结论:桥接组合式内固定系统与锁定钢板两种内固定技术治疗锁骨中段骨折,均能达到预期的治疗效果,两种修复方法在术后肩关节功能方面无显著差异,桥接组合式内固定系统在手术时间、术中出血量、骨折愈合时间及总体并发症方面较锁定钢板有一定优势。但限于该研究方法学质量的影响,文章结果还需谨慎对待,未来尚需要更多大样本、多中心随机对照试验进一步证实。吴桐 熊鹰 李焕龙 陈勇 刘璐赟 张珑 秦晶 Md Ariful Haque 2021中国组织工程研究2021,25,18:9
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