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| 1 | Imaging and radiological interventions in extra-hepatic portal vein obstruction显示文摘Extrahepatic portal vein obstruction(EHPVO) is a primary vascular condition characterized by chronic long standing blockage and cavernous transformation of portal vein with or without additional involvement of intrahepatic branches, splenic or superior mesenteric vein. Patients generally present in childhood with multiple episodes of variceal bleed and EHPVO is the predominant cause of paediatric portal hypertension(PHT) in developing countries. It is a pre-hepatic type of PHT in which liver functions and morphology are preserved till late. Characteristic imaging findings include multiple parabiliary venous collaterals which form to bypass the obstructed portal vein with resultant changes in biliary tree termed portal biliopathy or portal cavernoma cholangiopathy. Ultrasound with Doppler, computed tomography, magnetic resonance cholangiography and magnetic resonance portovenography are non-invasive techniques which can provide a comprehensive analysis of degree and extent of EHPVO, collaterals and bile duct abnormalities. These can also be used to assess in surgical planning as well screening for shunt patency in post-operative patients. The multitude of changes and complications seen in EHPVO can be addressed by various radiological interventional procedures. The myriad of symptoms arising secondary to vascular, biliary, visceral and neurocognitive changes in EHPVO can be managed by various radiological interventions like transjugular intra-hepatic portosystemic shunt, percutaneous transhepatic biliary drainage, partial splenic embolization, balloon occluded retrograde obliteration of portosystemic shunt(PSS) and revision of PSS. | Sudheer S Pargewar Saloni N Desai S Rajesh Vaibhav P Singh Ankur Arora Amar Mukund | 2016 | World Journal of Radiology2016，8，6： | 8 |
| 2 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 3 | Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer显示文摘AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).CONCLUSION: The Present data suggest that eN OS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC. | Devulapalli Krishnaveni Bhayal Amar Chand Porika Shravan Kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy Nallari Pratibha N Balakrishna Ananthapur Venkateshwari | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 2 |
| 4 | The web of human sexual contact显示文摘 | Rdling C R Amaral L A N | 2001 | Nature2001，411，6840： | 1 |
| 5 | Characterization and electrochemical performance of the spinel LiMn2O4 prepared from a- MnO2显示文摘 | FERRACIN L C AMARAL F A BOCCHI N | 2000 | Solid State Ionics2000，130，34： | 1 |
| 6 | Scaling behaviour in the growth of companies显示文摘 | Stanley M H R Amaral L A N Buldyrev S V Havlin S Leschhorn H Maass P Salinger M A Stanley H E | 1996 | Nature1996，379，： | 1 |
| 7 | Classes of small-world networks 显示文摘 | Amaral L A N | 2000 | National Acad Sciences2000，97，11： | 1 |
| 8 | Development of a finite element analysis tool for fixture design integrity verification and optimization 显示文摘 | Amaral N Rencis J J Rong Y M | 2005 | The International Journal of Advanced Manufacturing Technology2005，25，5： | 1 |
| 9 | Perotancous tanspedieular play methyl methacrylate vertebroplasty for the treatment of spinal compression fracture显示文摘 | Amar HP Larscn DW Eanaashari N | 2001 | Neom surgery2001，49，5： | 1 |
| 10 | Dicyclohexano-18-Crown-6 in Butanol-Octanol Mixture: A Promising Extractant of Sr( Ⅱ ) From Nitric Acid Medium显示文摘 | Amar K Mohapatra P K Pathak P N | 1997 | Talanta1997，45，： | 1 |
| 11 | Classes of Complex Networks Defined by Role-to-role Connectivi- ty Profiles显示文摘 | Guimera R Sales-Pardo M Amaral L A N | 2007 | Nature physics2007，3，1： | 1 |
| 12 | A model for the growth dynamics of economic organizations显示文摘 | Amaral L A N Gopikrishnan P Plerou V Stanley H E | 2001 | Physica A2001，299，： | 1 |
| 13 | Numerical analysis of adsorptive temperature wave regenerative heat pump显示文摘 | Amar N B Sun L M Meunier F | 1996 | Applied Thermal Engineering1996，16，5： | 1 |
| 14 | MicroRNAs differentially ex- pressed in ACTH - secreting pituitary tumors显示文摘 | Amaral FC Tortes N Saggioro F | 2009 | J Clin Endocrinol Metab2009，94，1： | 1 |
| 15 | Virtual round table on ten leading questions for network research显示文摘 | Barrat A Barabasi A L | 2004 | European Physical Journal B2004，38，2： | 1 |
| 16 | Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation显示文摘 | Amar S Gokce N Morgan S | 2003 | Arterioscler Thromb Vase Biol2003，23，7： | 1 |
| 17 | Lies,damned lies and statistics显示文摘 | Amaral L A N Guimera R | 2006 | Nature Physics2006，2，2： | 1 |
| 18 | Complex networks-augmenting the framework for the study of complex systems显示文摘 | Amaral L A N Ottino J M | 2004 | European Physical Journal B2004，8，2： | 1 |
| 19 | Functional cartography of complex metabolic networks 显示文摘 | Guimera R Amaral L A N | 2005 | Nature2005，433，7028： | 1 |
| 20 | Econophysics:can physicists contribute to the science of economics显示文摘 | Stanley H E Amaral L A N Canning D | 1999 | Physica A1999，269，1： | 1 |
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