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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment显示文摘Inflammatory bowel diseases(IBD),Crohns disease and ulcerative colitis,are chronic conditions associated with high morbidity and healthcare costs.The natural history of IBD is variable and marked by alternating periods of flare and remission.Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing,a great proportion of IBD patients remain symptomatic despite effective control of inflammation.These symptoms may include but not limited to abdominal pain,dyspepsia,diarrhea,urgency,fecal incontinence,constipation or bloating.In this setting,commonly there is an overlap with gastrointestinal(GI)motility and absorptive disorders.Early recognition of these conditions greatly improves patient care and may decrease the risk of mistreatment.Therefore,in this review we describe the prevalence,diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD. | Luísa Leite Barros Alberto Queiroz Farias Ali Rezaie | 2019 | World Journal of Gastroenterology2019，25，31： | 8 |
| 3 | Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study显示文摘Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease. | Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul Driss Boussaoud | 2019 | Neural Regeneration Research2019，14，4： | 6 |
| 4 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 5 | Evaluation of PCR assay in diagnosis and identification of cutaneous leishmaniasis: a comparison with the parasitological methods显示文摘 | Farideh Shahbazi Saed Shahabi Bahram Kazemi Mehdi Mohebali Ali Reza Abadi Zabiholah Zare | 2008 | Parasitology Research2008，，5： | 2 |
| 6 | Giardia intestinalis显示文摘 | Ali SA Hill DR | 2003 | Curr Opin infect Dis2003，16，5： | 1 |
| 7 | Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling 显示文摘 | Sattar R Ali SA Abbasi A | 2003 | Biochem Biophys Res Commun2003，308，4： | 1 |
| 8 | A closer look at food allergy and in tolerance显示文摘 | Ali R Ali SS | 2004 | J Coll Physicians Surg Pak2004，14，6： | 1 |
| 9 | A closer look at food allergy and intol- erance显示文摘 | Saeed SA Ali R Ali SS | 2004 | J Coil Physicians Surg Pak2004，14，6： | 1 |
| 10 | Absorption,distribution, metabolism,and excretion of a respirable antisense oligonu-cleotide for asthma显示文摘 | Ali S Leonard SA Kukoly CA | 2001 | Am J Respir Crit Care Med2001，163，4： | 1 |
| 11 | Antimicrobial resistance among neonatal pathogens in developing countries显示文摘 | Thaver D Ali SA Zaidi AK | 2009 | Pediatr Infect Dis J2009，28，1： | 1 |
| 12 | mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis 显示文摘 | Yasin SA Ali AM Tata M et at | 2013 | Acta Neuropathol2013，126，2： | 1 |
| 13 | Chemokines induce migrational responses in human breast carcinoma cell Lines显示文摘 | Youngs SJ Ali SA Taub DD | 1997 | Int J Cancer1997，71，2： | 1 |
| 14 | Pattern of pathogens and their sensitivity isolated from superficial surgical site infections in a tertiary care hospital显示文摘 | Ali SA Tahir SM Memon AS | 2009 | J Ayub Med Coll Abbottabad2009，21，2： | 1 |
| 15 | Antimicrobial resistance among neo- natal pathogens in developing countries 显示文摘 | Thaver D Ali SA Zaidi AK | 2009 | Pediatr Infect Dis J2009，28，1： | 1 |
| 16 | Efficacy of External Dacryocystorhinostomy(DCR)with and without Mitomycin-C in Chronic Dacryocystitis显示文摘 | Mukhtar SA Jamil AZ Ali Z | 2014 | J Coll Physicians Surg Pak2014，24，10： | 1 |
| 17 | Isolation,structural,and functional characterization of an apoptosis-inducing L-amino acid oxidase from leaf-nosed viper (Eristocophis macmahoni) snake venom显示文摘 | Ali SA Stoeva S Abbasi A | 2000 | Arch Biochem Biophys2000，384，2： | 1 |
| 18 | Spiral and oblique fractures of distal one-third of tibia-fibular:treatment resats with circular external fix- ator显示文摘 | Bahtiyar D Ali SA Murat B | 2007 | Ann Acad Med Singapore2007，36，： | 1 |
| 19 | An FPGA Based Implementation of CA-CFAR Processor显示文摘 | Saed T R Ali J K Yassen Z T | | 0，，04： | 1 |
| 20 | Pronounced susceptibility to infection by Salmonella enterlca serovar Typhimurium in mice chronically exposed to lead correlates with a shift to Th2-type immune responses 显示文摘 | Fernandez-Cabezudo M J Ali SA Ullah A | 2007 | Toxicol Appl Pharmacol2007，218，3： | 1 |
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