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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 3 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 4 | Intravitreal Triamcinolone Acetonide for Diffuse Diabetic Macular Edema: Phase 2 Trial Comparing 4 mg vs 2 mg显示文摘 | Fran?ois Audren Amélie Lecleire-Collet Ali Erginay Belkacem Haouchine Rym Benosman Jean-Fran?ois Bergmann Alain Gaudric Pascale Massin | 2006 | American Journal of Ophthalmology2006，，5： | 2 |
| 5 | Reversal of Hartmann's procedure:timing and operative technique显示文摘 | Roe AM Prabhu S Ali A | | 0，，10： | 1 |
| 6 | Management of open fractures of the lower limb显示文摘 | Ali AM Noyes D Cogswell LK | 2013 | Br J Hosp Med(Lond)2013，74，10： | 1 |
| 7 | Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum:identification of XAGE-1b as a dominant antigen and its immunogenicity in lung adenocarcinoma显示文摘 | Ali Eldib AM Ono T Shimono M | 2004 | Int J Cancer2004，108，： | 1 |
| 8 | mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis 显示文摘 | Yasin SA Ali AM Tata M et at | 2013 | Acta Neuropathol2013，126，2： | 1 |
| 9 | Induction of caspase-9,biochemical assessment and morphological changes caused by apoptosis in cancer cells treated with goniothalamin extracted from Goniothalamus macrophyllus显示文摘 | Alabsi AM Ali R Ali AM | 2013 | Asian Pac J Cancer Prev2013，14，11： | 1 |
| 10 | Impact of withholding breastfeeding at the time of vaccination on the immunogenicity of oral rotavirus vaccine--a randomized trial显示文摘 | Ali A Kazi AM Cortese MM | 2015 | PLo S One2015，10，01： | 1 |
| 11 | Cemented bipolar hemiarthroplasty with a cerclage cable technique for unstable intertrochanteric hip fractures in elderly patients显示文摘 | Abdelkhalek M Ali AM Abdelwahab M | 2013 | Eur J Orthop Surg Traumatol2013，23，4： | 1 |
| 12 | FAAP20 : a novel ubiquitin-binding FA nuclear core-complex protein re- quired for functional integrity of the FA-BRCA DNA re- pair pathway显示文摘 | Ali AM Pradhan A Singh TR | 2012 | Blood2012，119，14： | 1 |
| 13 | The strength of different fixation techniques for bicondylar tibial plateau fractures-a biomechanical study显示文摘 | Ali AM Saleh M Bolongaro S | 2003 | Clin Biomech2003，18，： | 1 |
| 14 | Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature 显示文摘 | Curtis BR Ali S Glazier AM | 2002 | Transfusion2002，42，9： | 1 |
| 15 | Ultrastructural char- acterization of the rabbit mandibular condyle following experimental induction of anterior disk displacement显示文摘 | Sharawy M Ali AM Choi WS | 2000 | Ceils Tissues Organs2000，167，1： | 1 |
| 16 | Risk factors and morbidity in patients with placenta previa accreta compared to placenta previa non-accreta显示文摘 | Zaki ZM Bahar AM Ali ME | 1998 | Acta Obstet Gynecol Scand1998，77，5： | 1 |
| 17 | scFv antibody : pr- inciples and clinical application显示文摘 | Ahmad ZA Yeap SK Ali AM | 2012 | Clinical and Develop- mental Immunology2012，，： | 1 |
| 18 | New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity显示文摘 | El-Bemerdash E Ali AA Sayed -Ahmed MM Osman AM | 2003 | Cancer Chemother Pharmacol2003，52，5： | 1 |
| 19 | Dual-hemisphere repetitive transcranial magnetic stimulation for rehabilitationof poststroke aphasia: a randomized, double-blind clinical tri- al 显示文摘 | Khedr EM Abo E1-Fetoh N Ali AM | 2014 | Neurorehabil Neural Repair2014，28，8： | 1 |
| 20 | Experimental induction of anterior disk displacement of the rabbit craniomandibular joint: an immuno-electron microscopic study of collagen and proteoglycan occurrence in the condylar cartilage显示文摘 | Sharawy M Ali AM Choi WS | 2003 | J Oral Pathol Med2003，32，3： | 1 |
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