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| 1 | Acute renal dysfunction in liver diseases显示文摘Renal dysfunction is common in liver diseases,either as part of multiorgan involvement in acute illness or secondary to advanced liver disease.The presence of renal impairment in both groups is a poor prognostic indicator.Renal failure is often multifactorial and can present as pre-renal or intrinsic renal dysfunction.Obstructive or post renal dysfunction only rarely complicates liver disease.Hepatorenal syndrome(HRS)is a unique form of renal failure associated with advanced liver disease or cirrhosis,and is characterized by functional renal impairment without significant changes in renal histology.Irrespective of the type of renal failure,renal hypoperfusion is the central pathogenetic mechanism,due either to reduced perfusion pressure or increased renal vascular resistance.Volume expansion,avoidance of precipitating factors and treatment of underlying liver disease constitute the mainstay of therapy to prevent and reverse renal impairment.Splanchnic vasoconstrictor agents,such as terlipressin,along with volume expansion,and early placement of transjugular intrahepatic portosystemic shunt(TIPS)may be effective in improving renal function in HRS.Continuous renal replacement therapy(CRRT)and molecular absorbent recirculating system(MARS)in selected patients may be life saving while awaiting liver transplantation. | Alex P Betrosian Banwari Agarwal Emmanuel E Douzinas | 2007 | World Journal of Gastroenterology2007，13，42： | 14 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients显示文摘AIM:To investigate factors predicting failure of percutaneous endoscopic gastrostomy(PEG)to eliminate gastroesophageal reflux(GER). METHODS:Twenty-nine consecutive mechanically ventilated patients were investigated.Patients were evaluated for GER by pH-metry pre-PEG and on the 7th post-PEG day.Endoscopic and histologic evidence of reflux esophagitis was also carried out.A beneficial response to PEG was considered when pH-metry on the 7th post-PEG day showed that GER was below 4%. RESULTS:Seventeen patients responded(RESP group)and 12 did not respond(N-RESP)to PEG.The mean age,sex,weight and APACHEⅡscore were similar in both groups.GER(%)values were similar in both groups at baseline,but were significantly reduced in the RESP group compared with the N-RESP group on the 7th post-PEG day[2.5(0.6-3.8)vs 8.1(7.4-9.2, P<0.001)].Reflux esophagitis and the gastroesophageal flap valve(GEFV)grading differed significantly between the two groups(P=0.031 and P=0.020, respectively).Histology revealed no significant differences between the two groups.CONCLUSION:Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. | Emmanuel E Douzinas Ilias Andrianakis Olga Livaditi Dimitrios Bakos Katerina Flevari Nikos Goutas Dimitrios Vlachodimitropoulos Marios-Konstantinos Tasoulis Alex P Betrosian | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 4 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 5 | Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection显示文摘 | Maria Fort Marina Sibila Miquel Nofrarías Eva Pérez-Martín Alex Olvera Enric Mateu Joaquim Segalés | 2010 | Veterinary Immunology and Immunopathology2010，，3： | 2 |
| 6 | Understanding geophysical responses of shale-gas plays显示文摘 | ZHU Y P LIU E R ALEX M | 2011 | The Leading Edge2011，30，3： | 1 |
| 7 | Development of PROSTVAC im- munotherapy in prostate cancer 显示文摘 | Singh P Pal SK Alex A | 2015 | Future Oncol2015，11，15： | 1 |
| 8 | Time series sales forecas- ting for short shelf-life food products based on artificial neural networks and evolutionary computing显示文摘 | Philip D Alex A Panagiotis P | | 0，，75： | 1 |
| 9 | Comparison of the immediate post-operative outcome of using the conventional two drains versus a single drain after lobectomy 显示文摘 | Alex J Ansari J Bahalkar P | 2003 | Ann Thorac Surg2003，76，4： | 1 |
| 10 | Giant tunnelling magnetoresistance at room temperature with MgO (100) tunnel barriers显示文摘 | Parkin S S P Kaiser Christian Panchula Alex | 2004 | Nature Materials2004，3，12： | 1 |
| 11 | Idiopathic inflammatory myopathies,signified by distinctive peripheral cytokines,chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand显示文摘 | Szodoray E Alex P Knowlton N | | 0，，： | 1 |
| 12 | A theoretical and experimental investigation of power harvesting using the NiMnGa martensite reorientation mechanism显示文摘 | Nickolaus M Bruno Constantin Ciocanel Heidi P Feigenbaum Alex Waldauer | 2012 | Smart Materials and Structures2012，，9： | 1 |
| 13 | A fuzzy linear basis algorithm for nonlinear separable programming problems显示文摘 | WANG P Z STERMARK R ALEX R | 2001 | Fuzzy Sets and Systems2001，119，： | 1 |
| 14 | Early cessation of triptorelin in in vitro fertilization:a double-blind,randomized study 显示文摘 | Arnold H M Henny J M Alex P E | 2005 | Fertil Steril2005，83，4： | 1 |
| 15 | Coping style as a psychological resource of grateful people显示文摘 | Alex M W Stephen J Linley A P | 2007 | Journal of Social and Clinical Psychology2007，26，9： | 1 |
| 16 | Salicylic acid-induced resistance to viruses and other pathogens: a parting of the ways?显示文摘 | Alex M Murphy Stephen Chivasa Davinder P Singh John P Carr | 1999 | Trends in Plant Science1999，，4： | 1 |
| 17 | An old herbal medicine with a potentiallynew therapeutic application in inflammatory bowel disease 显示文摘 | Li R Alex P Ye M | 2011 | Int JClin Exp Med2011，4，4： | 1 |
| 18 | Compound-specific D/H ratios of lipid biomarkers from sediments as a proxy for environmental and climatic conditions显示文摘 | Sauer P E Eglinton Hayes T I Sehimmelmann Amdt J M Sessions Alex L | 2001 | Geochimica et Cosmochimica Acta2001，65，： | 1 |
| 19 | Exact Voltage Unbalance Assessment Wihtout PhaseMeasurenents显示文摘 | Joaef A L Ghijselen Alex P M Van den Bossche | 2005 | IEEE Transactions on PowerSystem2005，20，1： | 1 |
| 20 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
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