|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 3 | Liquid chromatography-(tandem) mass spectrometry of selected emerging pollutants (steroid sex hormones,drugs and alkylphenolic surfactants) in the aquatic environment显示文摘 | de Alda M J L Diaz-Cruz S Petrovic M | 2003 | Journal of Chromatography A2003，1000，12： | 1 |
| 4 | Use of solid-phase extraction in various of its modalities for sample preparation in the determination of estrogens and progestogens in sediment and water显示文摘 | Lopezde Alda M J Barcelo D | 2001 | Journal of Chromatography2001，938，12： | 1 |
| 5 | Environmental Behavior and Analysis of Veterinary and Human Drugs in Soils,Sediments and Sludge显示文摘 | DIAZ-CRUZ M S LOPEZ DE ALDA M J BARCELO D | 2003 | Trends in Analytical Chemistry2003，22，6： | 1 |
| 6 | Drugs of abuse and their metabolites in the Ebro River basin : occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation显示文摘 | POSTIGO C DE ALDA M J L BARCELO D | 2010 | Environ Pollut2010，36，1： | 1 |
| 7 | Picogram per liter level determination of estrogens in natural waters and waterworks by afully automated on-line solid-phaseextraction-liquid chromatography-electrospray tandem mass spectrometry method显示文摘 | Rodriguez-Mozaz S Lopez de Alda M J Barcel D | 2004 | Anal Chem2004，76，23： | 1 |
| 8 | Endocrine disrupting compounds and other emerging contaminants in the environment: A survey on new monitoring strategies and occurrence data显示文摘 | Petrovic M Eljarrat E Lopez de Alda M J | 2004 | Analytical and Bioanalytical Chemistry2004，378，3： | 1 |
| 9 | Fast and simultaneous monitoring of organic pollutants in a drinking water treatment plant by a multi - analyte biosensor followed by LC - MS validation 显示文摘 | S Rodriguez - Mozaz M Lopez de Alda D Barcelo | 2006 | Talanta2006，69，2： | 1 |
| 10 | Determination of antimicrobials in sludge from infiltration basins at two artificial recharge plants by pressurized liquid extraction-liquid chromatography-tandem mass spectrometry显示文摘 | SILVIA DIAZ-CRUZ M JOSE LOPEZ DE ALDA M BARCELO D | 2006 | J Chromatogr:A2006，1130，1： | 1 |
| 11 | Recent advance in the mass spectrometric analysis related to endocrine disrupting compounds in aquatic environmental samples显示文摘 | PETROVIC M ELJARRAT E LOPEZ de ALDA M J | 2002 | Journal of Chromatography A2002，974，12： | 1 |
| 12 | Analysis of bisphenol A in natural waters by means of an optical immunosensor 显示文摘 | Rodriguez-Mozaz S Lopez de Alda M Barcelo D | 2005 | Water Research2005，39，20： | 1 |
| 13 | Monito- ring of estrogens, pesticides and bisphenol A in natural waters and drinking water treatment plants by solid- phase extraction-liquid chromatography-mass spectrome- try显示文摘 | Rodriguez-Mozaz S de Alda M J L Barcel6 D | 2004 | Journal of Chromatography A2004，1045，12： | 1 |
| 14 | Optical antennas for nano-photonic applications 显示文摘 | Alda J Rieo-Garcia J M L6pez-Alonso J M | 2005 | Nanotechnology2005，16，5： | 1 |
| 15 | Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge 显示文摘 | Diaz-Cruz M S Lopez de Alda M J Bareelo D | 2003 | Trac-Trends Anal Chem2003，22，： | 1 |
| 16 | Simultaneous multi - analyte determination of estrone, isoproturon and atrazine in natural waters by the River ANAlyser ( RIANA), an optical immunosensor显示文摘 | S Rodriguez - Mozaz S Reder M Lopez de Alda | 2004 | Biosensors and Bioelectronics2004，19，7： | 1 |
| 17 | Analysis and distribution of estrogens and progestogens in sewage sludge, soils and sediments显示文摘 | Kuster M de Alda M J L Barcelo D | 2004 | Trends in Analytical Chemistry2004，23，1011： | 1 |
| 18 | Functional properties and regulatory complexity of a minimal RBCS light-responsive unit activated by phytochrome,cryptochrome,and plastid signals显示文摘 | Alda M H Luisa L O Gerardo A A | 2002 | Plant Physiol2002，128，： | 1 |
| 19 | Measurement vitamin B12 by spectrophotometry 显示文摘 | Lopez de Alda M J Paseiro P | 1996 | J pharm Biomed Anal1996，14，3： | 1 |
| 20 | Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge 显示文摘 | Diaz-CruzM S Lopez de Alda M J Bareelo D | 2003 | Trends inAnalytieal Chemistry2003，22，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员