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| 1 | Prunus genetics and applications after de novo genome sequencing:achievements and prospects显示文摘Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry. | Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús | 2019 | Horticulture Research2019，6，1： | 8 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 4 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 5 | Structural Requirements of the Fructan-Lipid Interaction 显示文摘 | Ingrid J V J Albert van kuik Toon H E | 2003 | Biophysical Journal2003，84，： | 1 |
| 6 | Phylogeny and diversificatoin of B-function MADS-box genes in angiosperms: Evolutionary and functional implications of a 260-million-year-old duplication显示文摘 | Kim S Yoo M J Albert V A | 2004 | Am J Bot2004，91，： | 1 |
| 7 | Transparent conducting silver nanowire networks显示文摘 | JORIK V D G PIERPAOLO S ALBERT P | 2012 | Nano Lett2012，12，6： | 1 |
| 8 | Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy 显示文摘 | Risbud M V Albert T J Guttapalli A | 2004 | Spine2004，29，23： | 1 |
| 9 | Health-related quality of life among first-degree relatives of patients with obsessive-compulsive disorder in Italy显示文摘 | Albert U Salvi V Saracco P | 2007 | Psychiatr Serv2007，58，7： | 1 |
| 10 | Conifer homologues to genes that control floral development in angiosperums 显示文摘 | Tandre K Albert V A Sundas A | 1995 | Plant Mol Biol1995，27，： | 1 |
| 11 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 12 | Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer显示文摘 | Ziller V Kalder M Albert US | 2009 | Ann Oncol2009，20，3： | 1 |
| 13 | Highly stable 68 fs pulse generation from a stretched-pulse Yb^3+ -doped fiberlaser with frequency shifted feedback显示文摘 | Albert A Couderc V Barthelemy A | 2002 | IEEE Photonics Technology Letters2002，14，12： | 1 |
| 14 | A novel hybrid carbon mate- rial显示文摘 | Albert G N Peter V P | 2006 | Nature Nanotechnol2006，，2： | 1 |
| 15 | Metabolic engineering of the astaxanthin-biosynthetic pathway of Xanthophylomyces dendrorhous显示文摘 | Albert J J Van O | 2003 | FEMS Yeast Research2003，4，： | 1 |
| 16 | Randomized trial ofadjuvant intraperitoneal alpha-interferon in stage 111 ovariancancer patients who have no evidence of disease after primarysurgery and chemotherapy:an intergroup study 显示文摘 | Alberts D S Hannigan E V Liu P Y | 2006 | GynecolOncol2006，100，1： | 1 |
| 17 | High-energy femtosecond pulses from an ytterbium-doped fiber laser with a new cavity design显示文摘 | Albert A Couderc V Lefort L | 2004 | IEEE Photonics Technol Lett2004，16，2： | 1 |
| 18 | Metabolic syndrome in Italian patients with bipolar disorder显示文摘 | Salvi V Albert U Chiarle A | 2008 | Gen Hosp Psychiatry2008，30，4： | 1 |
| 19 | Deposition of CuIn(Se,S)2 Thin Films by Sulfurization of Selenized Cu/In Alloys显示文摘 | Sheppard C J Alberts V Bekker W J | 2004 | Physica StatusSolidi(a)2004，201，10： | 1 |
| 20 | 显示文摘 | Bekker J Alberts V Leitch A W R | 2003 | Thin Solid Films2003，431，： | 1 |
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