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| 1 | Metachronous gastric cancer after successful Helicobacter pylori eradication显示文摘The high incidence of gastric cancer in Japan initially resulted in establishment of a country-wide gastric cancer screening program to detect early and treatable cancers. In 2013 countrywide Helicobacter pylori(H. pylori) eradication was approved coupled with endoscopy to assess for the presence of chronic gastritis. Current data support the notion that cure of the infection in those with non-atrophic gastritis will prevent development of gastric cancer. However, while progression to more severe damage is halted in those who have already developed, atrophic gastritis/gastric atrophy remain at risk for subsequent development of gastric cancer. That risk is directly related to the extent and severity of atrophic gastritis. Methods to stratify cancer risk include those based on endoscopic assessment of the atrophic border, histologic grading, and non-invasive methods based on serologic testing of pepsinogen levels. Continued surveillance is required because those with atrophic gastritis/gastric atrophy retain considerable gastric cancer risk even after H. pylori eradication. Those who have already experienced a resectable early gastric cancer are among those at highest risk as metachronous lesions are frequent even after H. pylorieradication. We review the role of H. pylori and effect of H. pylori eradication indicating the incidence and the predictive factors on development of metachronous cancer after endoscopic therapy of early gastric cancer. Studies to refine risk markers to stratify for risk, surveillance methods, intervals, and duration after successful H. pylori eradication, and whether adjuvant therapy would change risk are needed. | Akiko Shiotani Ken Haruma David Y Graham | 2014 | World Journal of Gastroenterology2014，20，33： | 5 |
| 2 | Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein显示文摘 | Akiko E Bryan R M Chang Y C | 2009 | Nature2009，6，： | 1 |
| 3 | Haploinsufficiency and acquired loss of Bclllb and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model显示文摘 | Akiko N Norimasa Y Kazuko M | 2009 | Cancer Sci2009，100，7： | 1 |
| 4 | Control of Crystal Shape and Modification of Calcium Carbonate Prepared by Precipitation from Calcium Hydrogen Carbonate Solution显示文摘 | Yoshiyuki K Akiko S Tamotsu Y | 1992 | Jpn J Ceram Soc1992，100，9： | 1 |
| 5 | Long-term survival of bone marrow-derived retinal nerve cells in the retina显示文摘 | Keizo M Yasushi A Haruhiko Y Akiko H Yasuhiro S | 2005 | Neuro Report2005，16，12： | 1 |
| 6 | Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats:Involvement of local gonadotropin-releasing hormone显示文摘 | Mitsumori K Yutaka S Akiko Y | 2003 | Endocrinology2003，144，8： | 1 |
| 7 | Frequency and risk factors for neovascular glaucomaafter vitrectomy in eyes with proliferative diabetic retinopathy显示文摘 | Akiko G Inatani M Inoue T Awal-Kasaoka N Takihara Y ItoY | 2013 | J Glaucoma2013，22，7： | 1 |
| 8 | Characterization of left ventricular filling abnormalities and its relation to elevated plasma brain natriuretic peptide level in acute to chronic diastolic heart failure显示文摘 | SHINJI N AKIKO G MASAO Y | 2007 | Circ J2007，71，： | 1 |
| 9 | Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria显示文摘 | Takeshi Y Akiko S Yu-kI | 2003 | Circulation2003，108，： | 1 |
| 10 | Suppressive Effect of Abscisic Acid on Systemic Acquired Resistance in Tobacco Plants 显示文摘 | Miyuki K Michiko Y Akiko K | 2010 | Journal of General Plant Pathology2010，76，2： | 1 |
| 11 | Vascular endothelial cadherin mediated cell cell adhesion regulated by a small GTPase, Rap1显示文摘 | Shigetomo F Atsuko S Akiko Y | 2006 | J Biochem Mol Biol2006，39，2： | 1 |
| 12 | Effects of the oral administrationof green tea polyphenol and tannic acid on serum and hepatic lipidcontents and fecal steroid excretion in rats显示文摘 | YUMIKO N AKIKO K KIMIHIKO Y | 2001 | J Health Sci2001，47，2： | 1 |
| 13 | Cdx gene deficiency compromises embryonic hematopoiesis in the mouse显示文摘 | Yuan Wang Akiko Y Shannon Mckinney-Freeman | 2008 | Pnas2008，105，22： | 1 |
| 14 | Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model显示文摘 | Akiko N Norimasa Y Kazuko M | | Cancer Science0，，： | 1 |
| 15 | Enzymatic hydrolysis of ethanol-insoluble proteins from royal jelly and identification of ACE inhibitory peptide显示文摘 | Toshiro M Akiko Y Shima D | 2006 | Journal of the Japanese Society for Food Science and Technology2006，53，4： | 1 |
| 16 | Cloning and Characterization of the dnaKJ Operon in Acembacter areti显示文摘 | Akiko O K Wang Y Masahiro F | 2004 | Journal of Bioacience and Bicengneering2004，97，5： | 1 |
| 17 | Control of Crystal Shape and Modification of Calcium Carbonate Prepared by Precipitation from Calcium Hydrogen Carbonate Solution显示文摘 | Yoshiyuki K Akiko S Tamotsu Y | 1992 | J Ceram Soc1992，100，9： | 1 |
| 18 | Differentiation inhibitory factor nm23 as a new prognostic factor in acute monocytic leukemia显示文摘 | Akihiro Y Junko O K Akiko S | 1996 | Blood1996，88，1： | 1 |
| 19 | Monitoring the expression profiles of 7 000 Arabidopsis genes under drought,cold and high-salinity stresses using a full-lenghth cDNA microarray显示文摘 | Motoaki S Mari N Junko I Tokihiko N,Miki F,Youko O,Asako K,Maiko N,Akiko E,Tetsuya S,Masakazu S,Kenji A,Teruaki T,Kazuko Y S,Piero C,Jun K,Yoshihide H,Kazuo S | | 0，，： | 1 |
| 20 | Hypergamaglobulinemic purpura associated with sjogren,s syndrome and chronic C type hepatitis 显示文摘 | Toshiyuki Y Akiko Y | 2013 | The Journal of Dermatology2013，24，1： | 1 |
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