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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 5 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 6 | Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine显示文摘 | Wakitani S Saito T Caplan AI | | 0，，： | 2 |
| 7 | Periodic solutions in a model of competition between plasmid-bearing and plasmid-free organisms in a chemostat with an inhibitor 显示文摘 | Ai S B | 2001 | J Math Biol2001，42，： | 2 |
| 8 | Physicochemicai properties of caseinstarch interaction obtained by extrusion process显示文摘 | FERNANDEZ-GUTIERRES J A MARTIN-MARTfNEZ E S MARTINEZ-BUSYOS F et ai | 2004 | Starch2004，56，： | 1 |
| 9 | Pharmacological studies of human urinary kallidinogenase ( SK-827 ) : effects on arterial and regional blood flow 显示文摘 | Suzuki T Hirooka K Nakamura S et aI | 1993 | App Pharmacol1993，45，： | 1 |
| 10 | An approach to knowledge in database system显示文摘 | Cheek K S Ai K S | 1992 | Application Intellect1992，5，3： | 1 |
| 11 | Recent Advances in Analysis of Chinese Medical Plants and Traditional Medicines显示文摘 | Jitka Moravcova | 2004 | Journal of Chromatography B2004，，812： | 1 |
| 12 | Clinical significance of antinucleosome antibodies in Tunisian systemic lupus erythematosus patients显示文摘 | Ben Ayed M Baklouti S | 2005 | Clin Rheumatol2005，24，3： | 1 |
| 13 | Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine显示文摘 | Wakitani S Saito T Caplan AI | 1995 | Muscle Nerve1995，18，： | 1 |
| 14 | Recovering copper from electric cable wastes using a particle shape separation technique显示文摘 | Koyanaka S Ohya H Endoh S et aI | 1997 | Advanced Powder Technology1997，8，2： | 1 |
| 15 | GPS Positioning in a Multipath Environment显示文摘 | Jerome S lnbar F Patrick D et aI | 2002 | IEEE Transactions on Signal Processing2002，50，1： | 1 |
| 16 | Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma显示文摘 | Mukherjee S Roth M J Dawsey SM et ai | | J Transl Med0，，1： | 1 |
| 17 | Oxidation Activity and Acidity of V2O5 - P2O5 Catalyst 显示文摘 | AI M SUZUKI S | 1974 | Bulletin of Chemical Society of Japan1974，47，12： | 1 |
| 18 | Use of the 16S-23S ribosomal genes spacer region in studies of prokaryotic diversity显示文摘 | Garcia-Martinez J Acinas S G Anton AI Rodriguez-Valera F | 1999 | Microbial Meth1999，36，： | 1 |
| 19 | Spontaneous intracerebral hemorrhage显示文摘 | Qureshi AI Tuhrim S Broderick JP | 2001 | N Engl J Med2001，344，19： | 1 |
| 20 | Mixed mode fatigue crack growth criteria显示文摘 | Ai K S Li C B | 2001 | International Journal of Fatigue2001，23，5： | 1 |
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