|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Shenkang Ⅶ Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway显示文摘This study aimed to explore the protective effects of the traditional Chinese Medicine formula Shenkang Ⅶ recipe(SK-7)on renal fibrosis and the mechanisms.Renal fibrosis was induced by unilateral ureteral obstruction(UUO)in rats.The rats were then divided into 5 groups:control group(Sham operation),UUO model group,UUO model plus low to high doses of SK-7(0.5,1.0,or 2.0 g/kg/day,for 14 days)groups.The animals were sacrificed on the 7th or 14th day.K idney tissues were collected for histopathological exarminations(hematoxylin and cosin and Masson's trichrome staining).Immunohistochemistry was used to detect the expression of collagen type II(Col II),fibronectin(FN),α-smooth muscle actin(a-SMA),TIMP metallopeptidase inhibitor 2(TIMP2),matrix metallopeptidase 2(MMP2),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)and monocyte chemotactic protein-1(MCP-1).The TGF-β1/Smad,NF-κB and Sonic hedgehog signaling proteins were detected by Western blotting.Our results showed that SK-7 prevented UUO-induced renal injury and accumulation of collagen fibrils.Renal fbrosis biomarkers Col Ⅲ,FN,α-SMA and TMP2 were increased in the rats after UUO and decreased by SK-7,while MMP2 was upregulated after treatment.SK-7 also suppressed the levels of TNF-α,IL-1βand MCP-1 in UUO rats.In addition,SK-7 inhibited activation of the TGF-B/Smad,NF-κB and sonic hedgehog signaling(SHH)pathways.Taken together,these findings suggest that SK-7 may regulate the synthesis and degradation of extracellular matrix,reduce inflammation and suppress the proliferation of fibroblasts,by blocking the TGF-β1/Smad,NF-κB and SHH signaling pathways to exert its anti-renal fbrosis effect in UUO rats. | Shan-shan ZHOU Zhong-zhu AI Wei-nan LI Liang LI Xiao-yun ZHU Yuan-ming BA | 2020 | Current Medical Science2020，40，5： | 3 |
| 2 | Cervical pregnancy: case reports and acurrent literature review显示文摘 | Marcovin I Rosenzweig BA Brill AI | 1994 | Obstet Gynecol Surv1994，49，： | 1 |
| 3 | Cervical pregnancy: case reports and acurrent literature review显示文摘 | Marcovin I Rosenzweig BA Brill AI | 1994 | Obstet Gynecol Surv1994，49，： | 1 |
| 4 | Caspase pathways,neuronal apoptosis,and CNS injury显示文摘 | Eldadah BA Faden AI | | 0，，： | 1 |
| 5 | Ultrasound diagnosis acute cancer-related colorectal obstruction显示文摘 | Min'ko BA Kushnerov AI Pruchanskii VS | 2003 | Vopr Onkol2003，49，6： | 1 |
| 6 | Caspase pathways,neuronal apoptosis,and CNS injury显示文摘 | Eldadh BA Faden AI | 2000 | J Nneurotrauma2000，17，10： | 1 |
| 7 | Metabotropic glutamate receptor- mediated signaling in neuroglia 显示文摘 | Loane DJ Stoica BA Faden AI | 2012 | Wiley Interdiscip Rev Membr Transp Signal2012，1，2： | 1 |
| 8 | Factors affect- ing visual outcome in ehildren following uniocular trau- matic cataraet显示文摘 | Chruchill AI Noble BA Etchells DE | 1995 | Eye1995，9，3： | 1 |
| 9 | The role of imaging in the diagnosis and management of thoracolumbar burst fractures:current concept and a review of the Ifterature显示文摘 | Saifuddin A Noordeen H Tay]or BA et aI | 1996 | Skeletal gadiol1996，25，7： | 1 |
| 10 | Caspase pathways,neuronal apoptosis,and CNS injury显示文摘 | Eldadah BA Faden AI | 2000 | J Neurotrauma2000，17，10： | 1 |
| 11 | Caspase pathways, neuronal apoptosis, and CNS injury显示文摘 | Eldadah BA Faden AI | 2000 | J Neurotrauma2000，17，10： | 1 |
| 12 | Development and testing of an anti-tobacco school-based curriculum for deaf and hard of hearing youth显示文摘 | Berman BA Guthmann DS Crespi CM et ai | 2011 | American annals of the deaf2011，155，5： | 1 |
| 13 | Cervical pregnancy:case reports and a current literature review显示文摘 | Mareovic I Rosenweig BA Brill AI | 1994 | Obstet Gynecol Sury1994，49，1： | 1 |
| 14 | The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis 显示文摘 | Wang S Aurora AB Johnson BA et aI | 2008 | DevCell2008，15，2： | 1 |
| 15 | Peliability of pelvic floor muscle strength assessment using different test positions and tools显示文摘 | Frawley HC Galea MP Phillips BA et aI | 2006 | Neurourol Urodyn2006，25，5： | 1 |
| 16 | Caspase pathways, neuronal apoptosis, and CNS injury显示文摘 | Eldadah BA Faden AI | 2000 | J Neurotrauma2000，17，： | 1 |
| 17 | Trealmewt of dis-tal tibia fra- Lures without articular involvement a system-alic review of 1125 frac- tu res显示文摘 | Zelle BA Bhandari M Espirhu M el aI | 2006 | J Orthop Tramna2006，20，1： | 1 |
| 18 | Beta-amyloid-induced apoptosis of cerebullar granule cells and cortical neurons: exacerbation by selective inhibition of group imetabotropic glutamate receptors 显示文摘 | Allen JW Eldadah BA Faden AI | 1999 | Neuropharma-cology1999，38，8： | 1 |
| 19 | Cerrical pregnancy : casereports and a current literature review显示文摘 | Marcovic I Rosenzweig BA BRILL AI | 1994 | Obtet Gynecol Sury1994，49，1： | 1 |
| 20 | The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells 显示文摘 | Eldadah BA Yakovlev AG Faden AI | 1997 | J Neurosci1997，17，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员