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| 1 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 2 | Mild cognitive impairment:directions for future research显示文摘 | Luis CA Loewenstein DA Acevedo A | 2003 | Neurology2003，61，4： | 1 |
| 3 | Enzymes as useful tools for environmental purposes 显示文摘 | Rao M A Scelza R Acevedo F | 2014 | Chemosphere2014，107，： | 1 |
| 4 | Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies显示文摘 | Loewenstein DA Acevedo A Agron J | 2006 | Dement Geriatr Cogn Disord2006，21，56： | 1 |
| 5 | T-type Ca^2+ channels in sperm function 显示文摘 | Darszon A Lopez-Martinez P Acevedo JJ | 2006 | Cell Calcium2006，40，2： | 1 |
| 6 | CO2 supply in the biooxidation of an enargite-pyrite gold concentrate 显示文摘 | ACEVEDO F GENTINA J C GARC A N | 1998 | Biotechnology Letters1998，20，3： | 1 |
| 7 | Expression of membrane-associated human chorionic gonadotropin, its subunits, and fragments by cultured human cancer cells 显示文摘 | Acevedo HF Krichevsky A Campbell-Acevedo EA | 1992 | Cancer1992，69，7： | 1 |
| 8 | Apoptosis in chronic adult periodontitis analyzed by in situ DNA breaks, electron microscopy, and immunohistochemistry显示文摘 | Gamonal J Bascones A Acevedo A | 2001 | J Periodontol2001，72，4： | 1 |
| 9 | Mild cognitive impairment-directions for future research 显示文摘 | Luis CA Loewenstein DA Acevedo A | 2003 | Neurology2003，61，： | 1 |
| 10 | Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies显示文摘 | Loewenstein DA Acevedo A Agron J | 2006 | Dement Geriatr Cogn Disord2006，21，56： | 1 |
| 11 | ILAE official report: a practical clinical definition of epilepsy 显示文摘 | Fisher RS Acevedo C Arzimanoglou A | 2014 | Epilepsia2014，55，： | 1 |
| 12 | A practical clini- cal definition of epilepsy 显示文摘 | Fisher RS Acevedo C Arzimanoglou A | 2014 | Epilepsia2014，55，4： | 1 |
| 13 | Mild cognitive impair- ment :directions for future research 显示文摘 | Luis CA Loewenstein DA Acevedo A | 2003 | Neurology2003，61，： | 1 |
| 14 | Human papillomavirus DNA and protein in tissue samples of oesophageal cancer, Barrett's oesophagus and oesophagitis显示文摘 | Acevedo E Gonzalez Ojeda A Vazquez Camacho G | 2004 | Anticancer Res2004，24，2： | 1 |
| 15 | Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy显示文摘 | Acevedo CH Ahmed A | 1998 | J Clin Invest1998，101，： | 1 |
| 16 | Apoptosis in chron- ic adult periodontitis analyzed by in situ DNA breaks, electron microscopy, and immunohistochemistry 显示文摘 | Gamonal J Bascones A Acevedo A | 2001 | J periodontal2001，72，4： | 1 |
| 17 | Characterization of ob- stetric patients with multiple organ failure in the intensive care u- nit of a Havana teaching hospital, 1998 to 2006 显示文摘 | Perez A Acevedo O Tamayo Fdel C | 2010 | MEDICC Rev2010，12，2： | 1 |
| 18 | Mild cognitive impairment directions for future research 显示文摘 | hais CA koewenstein DA Acevedo A | 2003 | Neurology2003，61，： | 1 |
| 19 | ILAE Official Report:A practical clinical definition of epilepsy显示文摘 | Fisher RS Acevedo C Arzimanoglou A | 2014 | Epilepsia2014，55，4： | 1 |
| 20 | Cognitive profiles in Alzheimer's disease and in mild cognitive impairment of different etiologies 显示文摘 | Loewenstein DA Acevedo A Agron J | 2006 | Dement Geriatr Cogn Disord2006，21，56： | 1 |
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